黑瘤

Objective To investigate the inhibitory effect of acitretin and thalidomide on proliferation of mouse melanoma B16 cells.

目的探讨阿维A酸和沙利度胺对鼠黑素瘤细胞株B16增殖的抑制作用。

Through Enzyme assay of biochemical to detect the inhibitory effect of the extract on the activity of tyrosinase.

动物细胞实验检测提取液对小鼠B16黑素瘤细胞增殖抑制率的影响，细胞内黑色素含量和细胞内酪氨酸酶活力测定。

Here we report frequent somatic mutations in the heterotrimeric G protein alpha-subunit, GNAQ, in blue naevi (83%) and ocular melanoma of the uvea (46%).

我们在此报道了蓝痣(83%)和眼葡萄膜黑素瘤(46%)中异源三聚体G蛋白α亚单位——GNAQ——的屡次突变。

Key words:Approximative diagnosis;Medical coding;Acanthosis nigricans;Keratoacanthoma

关键词］诊断近似；医学编码；黑棘皮病；角化棘皮瘤

CFC syndrome and CS can be distinguished from NS by the presence of ectodermal abnormalities, mental retardation and a lack of familial cases. CFC syndrome can be distinguished from CS by the rare presence of papillomata, fetal pads, acanthosis nigricans, wrinkled palms and soles, and loose skin of the hands and feet.

心脏－脸－皮肤徵候群及科斯特洛徵候群二者均具有外胚层的异常，智障，及缺乏家族案例，这些可以和努男徵候群区别；而心脏－脸－皮肤徵候群患者罕见乳突瘤，胎儿垫，黑棘皮病，手掌脚掌皱纹及手脚疏松的皮肤，这些可以和科斯特洛徵候群区别。

And a birch bark compound, betulinic acid, is being tested as a treatment for melanoma and other serious diseases.

一、桦树皮大院桦木酸，正测试作为治疗黑素瘤和其他严重疾病。

A number of studies have suggested that apoptosis and its regulation plays an important pathogenic role in the chemoresistance of human melanoma.

现有研究已证实凋亡及其调节因子是决定恶性黑素瘤耐药的重要机制。

Our research has showed that Mcl-1 AS-ODN can partially reverse the chemoresistance of melanoma.

我们前期工作也显示Mcl-1反义寡核苷酸可部分逆转恶性黑素瘤的耐药性。

Multidrug resistance is the vital factor of ineffective treatment in malignant melanoma. Thus, one of the main goals for melanoma treatment is to reverse chemoresistance of tumor cells.

而多药耐药是其临床化疗失败的主要原因，因此，逆转肿瘤的耐药性是治疗恶性黑素瘤的重要课题。

The therapy of malignant melanoma is still a tough problem up to now, most dermatologists including dermatological surgeons often lack a clear understanding about it.

恶性黑素瘤的治疗至今仍是一个难题，大多数皮肤科医生包括皮肤外科医生对此往往缺乏清晰的认识。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。