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The Quakers Hill girls, aged seven and five, were born with Leber's Congenital Amaurosis - while they were still in the womb their retinas were already deteriorating due to a missing protein.

这两个分别为5岁和7岁的女孩，他们出生时就患有Leber氏先天性黑曚，当他们还在母亲的子宫里时，他们的视网膜已经恶化因为缺少蛋白质。

Results Among the 50 patients,15 cases have the history of smoking and 10 cases have the history of drinking. 23（46%）show preomonitory symptoms before the onset such as headache of different degree with or without uniophthalomolegia , mental disorder and amaurosis occasionally, descent of the sight gradually and neck pain from 3 to 40 days.

结果 15例SAH患者有吸烟史，10例有饮酒史。23例患者（占46%）在发病前3~40天有前驱症状：不同程度的头痛伴或不伴一侧眼肌麻痹、一过性精神障碍、颈痛、一过性黑蒙、视力逐渐下降等表现。

The trial involves adults and children who have a condition called Leber's congenital amaurosis, which is a type of inherited retinal degeneration.

该项试验涉及患有莱伯氏先天性黑蒙的儿童和成人。

Most faint has dazed, bosom first before happen frowsty, at the moment the symptom such as amaurosis, what not be like little show effect is abrupt happen, the refreshment of consciousness and physical strength is slower also.

大多数的晕厥在发生前先有头昏、胸闷、眼前黑朦等症状，不似小发作的突然发生，意识和体力的恢复也比较缓慢。

RESULTS: Of the 74 patients, 23 (31%) had ocular manifestations accompanied by other symptoms, including 3 (4.1%) with ocular syndrome accompanied with headache as the first symptoms of Moyamoya disease. Digital subtract angiography examination revealed 24 patients (32.4%) had unilateral or double stenosis of internal carotid artery, among which 3 patients had ocular syndrome. All positive eye findings included amaurosis fugax (13%), hemianopia (17%), decline or loss of the visual ability and lesions of visual fields (44%), papillary size dysfunction (13%), pupil direct/indirect light reflex (13%), ptosis (9%), nystagmus (4%), ocular dyscinesia (13%), and fossa orbitalis tenderness (9%).

结果：74例Moyamoya病患者中眼部症状与其它症状同时发生者23例（31%），其中仅以眼部症状伴头痛表现为首发症状就诊者3例（4%）；DSA检查显示单侧或双侧颈内动脉狭窄者24例（32%），其中3例患者双侧颈内动脉完全闭塞，而无任何眼部症状；23例患者所伴眼症表现主要为一过性黑朦13%，偏盲17%，视力下降甚至丧失44%，瞳孔大小异常13%，瞳孔直接/间接对光反射消失13%，上睑下垂9%，眼球震颤4%，眼球运动障碍13%，眼眶压痛9%。

Amongst the many important functions of the RPE, it has the ability to phagocytosis and digest the rod outer segments which is shed on a daily basis. The malfunction of RPE leads to retinal diseases, such as retinitis pigmentosa, Best"s disease, Stargardt"s disease,Lebers congenital amaurosis and age-related macular degeneration.

RPE能吞噬脱落的视细胞外节膜盘(rod outer segment，ROS)，这对视细胞外节的更新及维持正常视觉功能至关重要，其功能障碍会导致严重视网膜疾病和一些严重的遗传性变性眼病，如Best病，Stargardt病和Leber先天性黑矇，年龄相关性黄斑变性(age-related macular degeneration，AMD)等。

Amongst the many important functions of the RPE, it has the ability to phagocytosis and digest the rod outer segments which is shed on a daily basis. The malfunction of RPE leads to retinal diseases, such as retinitis pigmentosa, Best\'s disease, Stargardt\'s disease,Leber\'s congenital amaurosis and age-related macular degeneration.

RPE能吞噬脱落的视细胞外节膜盘(rod outer segment，ROS)，这对视细胞外节的更新及维持正常视觉功能至关重要，其功能障碍会导致严重视网膜疾病和一些严重的遗传性变性眼病，如Best病，Stargardt病和Leber先天性黑矇，年龄相关性黄斑变性(age-related macular degeneration，AMD)等。

Dizziness, headache, tinnitus, vision loss, behavioral abnormalities, unresponsiveness, memory decline, involuntary drooling mouth, side of limb numbness, inability or activity problems, palpitation, chest tightness, chest pain, amaurosis eyes, cough, dyspnea activity, paroxysmal nocturnal dyspnea, lower extremity edema and so on.

头晕，头痛，耳鸣，视力减退，行为异常，反应迟钝，记忆力下降，嘴角不自主流口水，一侧肢体麻木、无力或活动不灵，心慌，胸闷，胸痛，眼前黑朦，咳嗽、活动时气急，夜间阵发性呼吸困难，下肢浮肿等。

Familiar inducement were prolonged standing(43.64%),change of position(20.00%),and so on.Common prodromes were dizziness(78.18%),impotence(29.09%),pallor(27.27%),sweating(27.27%),palpitation(25.45%),amaurosis(23.64%),dyspnea(21.82%),headache(21.82%)and so on.

结果74.55%和96.36%的VVS儿童存在晕厥诱因和先兆症状，常见诱因有长久站立(43.64%)、体位改变(20.00%)等；常见先兆症状为头晕(78.18%)、乏力(29.09%)、面色苍白(27.27%)、大汗(27.27%)、心慌(25.45%)、黑朦(23.64%)、胸闷(21.82%)、头痛(21.82%)等。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。