黄连素

Elimination of conjugative drug resistance plasmids and nonconjugative drug resistanceplasmids from 20 and 19 Shigella strains respectively by norfloxacin and berberine in vitro were analysed.

用氟哌酸和黄连素对20株携有接合传递耐药性质粒及19株携有非接合传递耐药性质粒志贺氏菌进行体外消除研究。结果显示，可被消除的耐药性质粒大多数在24小时内被消除。

The anti-ischemia effect in myocardium of corydalis rhizoma is related to the direct protective effects on cardiomyocytes of its components, tetrahydropalmatine, dehydrocorydaline, berberine and palmatine, amomg which tetrahydropalmatine and dehydrocorydaline are the most important, the former with high safety and low efficacy, while the latter with low safety and high efficacy. And the direct protective effects on cardiomyocytes of these four components, may be attained through mechanisms other than anti-peroxidation.

延胡索抗心肌缺血损伤的作用与其成分延胡索乙素、脱氢紫堇碱、黄连素和巴马汀对心肌细胞的直接保护能力有关；其中，延胡索乙素和脱氢紫堇碱的作用最为重要，前者安全性高，但效能较低，后者安全性低，而效能较高；而这4个单体的保护作用可能是通过抗氧化损伤之外的机制达到的。

The anti-ischemia effect in myocardium of Rhizoma Corydalis is related to the direct protective effects on cardiomyocytes of its components, tetrahydropalmatine, dehydrocorydaline, berberine and palmatine, amomg which tetrahydropalmatine and dehydrocorydaline are the most important, the former with high safety and low efficacy, while the latter with low safety and high efficacy. And the direct protective effects on cardiomyocytes of these four components may be attained through mechanisms other than anti-peroxidation.

延胡索抗心肌缺血损伤的作用与其成分延胡索乙素、脱氢紫堇碱、黄连素和巴马汀对心肌细胞的直接保护能力有关；其中，延胡索乙素和脱氢紫堇碱的作用最为重要，前者安全性高，但效能较低，后者安全性低，而效能较高；而这4个单体的保护作用可能是通过抗氧化损伤之外的机制达到的。

Aim To observe the effects of Chlamydia pneumoniae infection on migration of endothelial cells, to investigate the interventive effect of Berberine on Chlamydia pneumoniae induced-endothelial cell migration and to explore its possible mechanism.

目的 观察肺炎衣原体感染对人血管内皮细胞迁移的影响，探讨黄连素对其干预作用及作用机制。

Berberine is an isoquinoline derivative alkaloid isolated from many medicinal herbs. It is widely used in traditional Chinese medicine for the treatment of inflammation diseases and anti-microbial activities.

黄连素，是一种在许多中草药都可以萃取出的生物碱，目前的研究指出，它有许多抑菌及抗发炎的药理作用。

Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anticancer effects in different human cancer cell lines.

黄连素是黄连主要的结构，是一种异奎啉类生物碱的型式，报告指出在不同的人类癌细胞有抗癌作用。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

The suitable oil phase, surfactant and cosurfactant were choused, the nanoemulsion drug delivery system of berberine were optimized by studying the pseudoternary phase diagram.

选择适宜的油相、表面活性剂和助表面活性剂，利用伪三元相图，制备出黄连素纳米乳给药系统。

Methods 120 cases were divided randomly into two groups by random number chart,control group received SASP and huangliansu,treatment group received huangqi jianzhong detortion,compared clinical efficiency and disease activity index after 30 days.

将120例溃疡性结肠炎患者按随机数字表法分为治疗组和对照组各60例，对照组采用口服柳氮磺胺吡啶和黄连素片，治疗组在对照组治疗基础上加用加味黄芪建中汤，治疗30天后比较临床疗效和疾病活动指数。

If the problems in your son, it cool with hot pepper or oil, berberine you put on the nipple, which he did not like the taste, after several no longer want to suck the breast of the.

如果这个用在你宝宝不灵的话，就用辣椒或者清凉油、黄连素呀抹在乳头，这些味他不喜欢，几次后就不再想吃奶了。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。