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Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁脲(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应,采用HPLC和LC-MS/MS法测定对应的7种代谢产物(1,7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁脲、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑)的浓度,通过与对照组比较,确定MPD对以上7种酶活性的影响。

It exists uncombined in two stable allotropes, one gray and one yellow, but is more often found in nature as the sulfide or oxide.

它存在两种稳定同素异性体,即灰砷和黄砷,但大多发现于自然界的硫化物和氧化物中。

During dehydration, the tolerance of wampee axes to desiccation which was analyzed as germination percentage, vigour index, and rate of electrolyte leakage, and activities of antioxidant enzymes gradually decreased, the content of malondialdehyde , progressively increased.

黄皮种子离体胚轴在脱水过程中,胚轴的萌发率、活力指数、电解质渗漏速率,超氧化物歧化酶、过氧化物酶和过氧化氢酶活性逐渐降低,膜质过氧化产物MDA的含量不断增加。

Results Compound albicanyl caffeate displayed strong antifungal property with MIC 4 μg/ml, while moderate antifungal effects (MIC16 μg/ml)were observed with compounds emodin, resveratrol, 3,4'-difluorostilbene, 2,2'-difluorostilbene and 2,3',5'-trifluorostilbene. Pakyonol, catechin, ampelopsin A, 3,4,4'-trihydroxyl- bibenzyl, 2,4'-difluorostilbene, 4-fluorostilbene,2-methyloxy-4'-fluorostilbene showed lower activity with MIC 32 μ g/ml.

结果化合物albicanyl caffeate对白色念珠菌表现出强的抗真菌活性,MIC为4μg/ml;而化合物大黄素、白藜芦醇、3,4'-二氟二苯乙烯、2,2'-二氟二苯乙烯及2,3',5'-三氟二苯乙烯显示出中等程度的抗真菌活性,MIC为16μg/ml;双联苄pakyonol、多酚类儿茶素、白藜芦醇二聚体野葡萄素A、3,4,4'-三羟基联苄、2,4'-二氟二苯乙烯、4-氟二苯乙烯及2-甲氧基-4'-氟二苯乙烯显示出较弱的抗真菌活性,MIC为32 μg/ml。

According to the design of part 2 above,antioxygen ability and ATPase activity of larval fish in each treatment were analyzed after feeding.

试验设计与第2部分相同,饲养结束后,测定各试验组黄颡鱼鱼体中抗氧化酶活性及ATP酶活性。

Two RAPD molecular markers located on different arms of 2Ai-2 chromosome from Thinopyrum intermedium were selected and the generations of the hybrid generation derived from Zhong 4 Awnless and wheat were analyzed. Two chromosome translocation lines were screened for wheat breeding program to control BYDV.

本研究采用RAPD方法,对具2Ai-2端体和完整染色体异附加或异代换系进行分析,从随机引物中,选出两个分别位于2Ai-2染色体两臂上的分子标记,然后用这两个标记对中间偃麦草和普通小麦的杂交后代进行筛选,选出小麦抗黄矮病易位系新材料。

The biosystematic relationship between two species of Nelumbo Adans.was studied by the method of karyotype analysis,genome analysis and silver-staining of interphase neclei in Nelumbo lutea Pers.

对莲属美洲黄莲和莲的3个品种的核型分析、染色体组分析和间期核银染,研究了莲属两个种的系统关系。莲属两个种的核型大致近似,均有2对具随体染色体。

Great wall lamp using high quality and high brightness chip to make the columnar LED bulb; composing can be red, green,blue,yellow,whiteand seven color transfor mation.material is soft PCB,can be bard by project requst,specialty high brightness,lowbrightness damply,large brighteness angle,high quality,usually use great wall light for the letters which,thin and tridimensinal like,sign bourd,identifers.Advertising,can be used.By lamp-house and decoration.

长城灯条先用优质高亮度芯片圆柱LED 作为发光体;可由红、绿、蓝、黄、白、七彩等不同颜色组成,基板为柔性PCB可因工程需要随意弯曲,具有高亮度,光衰低、发光角度大,品质优良,性能稳定等特点,长城灯条广泛应用于字体笔画较细,而且工艺复杂的立体发光字、招牌、标识、广告灯箱等,作为发光源使用,也可作为各种装饰工程、舞台灯光的光源使用。

Hyperstriatum ventrale pars caudal nucleus ; Vocal centre ; Fiber connection ; HRP tracing method ; Carduelis spinus

上纹状体腹侧尾核;发声中枢;纤维联系; HRP追踪法;黄雀

The efferent and afferent projections of the hyperstriatum ventrale, pars caudal nucleus in carduelis spinus were investigated using anterograde and retrograde HRP tracing techniques.

用HRP顺、逆行追踪方法,研究了鸣禽黄雀端脑上纹状体腹侧尾核的传出投射。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力