鸟嘌呤

Objective To study the relationship between CTG repeat frenquency in MTPK gene and the change of ECG in patients with myotonic dystrophy.

目的 研究强直性肌营养不良症患者的肌强直蛋白激酶基因中胞嘧啶、胸腺嘧啶、鸟嘌呤CTG）三核苷酸重复次数与DM病人心电图改变的关系。

Reactions of 2-methyl-1,4 naphthoquinone with human telomeric DNA and telomerase RNA ESR spin elimination has been used with 4-oxo-TEMPO as spin trap. The reactivities of 3VK3* with telomeric DNA, template of telomerase RNA and its L6-P6 region have been confirmed respectively. The results show that the reactivity of 3VK3* with polynucleotides is directly proportional to their G amount, and the one for reaction of 3VK3* with telomeric DNA is the highest in polynucleotides. 2. Reactions of 2-methyl-1,4 naphthoquinone with nucleosides, nucleotides ESR spin elimination has been used with 4-oxo-TEMPO as spin trap.

2-甲基-1，4萘醌与端粒DNA及端粒酶RNA亚基光敏反应性的研究应用ESR自旋消减法，对2-甲基-1，4萘醌(VK3)与端粒DNA重复序列、端粒酶RNA亚基模版序列、端粒酶RNA亚基L6-P6发夹区关键序列的光敏反应性进行了研究，结果表明，在一定波长照射下，明显诱导VK3与上述寡聚核苷酸反应，其反应性大小与核酸中鸟嘌呤含量正相关，其中端粒DNA序列反应性最强。

On long-term follow-up, about 5% of 6-thioguanine recipients have evidence of non-cirrhotic portal hypertension due to periportal liver fibrosis or nodular regenerative hyperplasia.

在长期随访过程中， 6-硫鸟嘌呤组约有 5%的患儿出现了非肝硬化性门静脉高压，这是由门静脉周围肝组织纤维化或结节再生性增生所引起的。

Resembles thymine, but easily interconverts to tautomeric form that pairs with guanine.

与胸腺嘧啶相似，但很容易转换成与鸟嘌呤配对的互变异构形式。

The binding behavior and kinetics of uncoupling protein with its ligand, the Fourier-transformation infrared spectra of uncoupling protein and its changes during ligand-binding process, the inhibition of Guanosine 5＇-Tetraphosphate (G-4-P) and Adenine-β-Darabinofuranoside 5＇-triphosphate on the binding of uncoupling protein with GTP were studied.

本文对解偶联蛋白与配基的结合及其结合动力学，解偶联蛋白及其与配基结合过程中的傅里叶变换红外光谱及其光谱变化，鸟嘌呤核苷四磷酸（G-4-P）和9-β-D-阿拉伯糖基呋喃5＇-三磷酸对解偶联蛋白与GTP结合的影响进行了研究。

Ras homolog enriched in brain, a small GTPase, positively regulates the mTORC1 pathway. The GDP-GTP exchange of Rheb has been suggested to be facilitated by translationally controlled tumor protein. Here we demonstrate that human TCTP interacts with human Rheb and accelerates its GDP release in vitro, and that hTCTP activates the mTORC1 pathway in vivo.

丁建平研究组运用体外 GST-pulldown 和鸟嘌呤交换等生物化学实验以及对 TCTP 降低表达和过量表达等细胞生物学实验，证明了人源 TCTP 具有针对 Rheb 的弱 GEF 活性，能正向调控 mTOR 信号通路。

The mutagen mechanism is presumed single factor dominant.(4)There was 85 percent transvertion in mutagen spectra, and they were all G:C→T:A transvertion. The maximal possibility of mutagen mechanism is analyzed as followed:ion beam implant → breakage cell surface and enter the interior → stimulate plentiful radical born → radical oxidize and damnify DNA → G becomes 8—oxoG → 8—oxoG pairing A → result in G:C→T:A transvertion(5)Production of transition was presumed that ion beam implantion damnified DNA, stimulate activity of MMR interveniented by methyl reducing.

诱发突变谱中碱基颠换比例是0.85，且是全部G：C→T：A颠换，推测低能离子束诱变鼠伤寒沙门氏菌得分子机制可能为：离子注入→通过破坏细胞表面进入内部→刺激产生大量自由基→自由基氧化损伤DNA→G变成8氧—7，8—二氢鸟嘌呤(8—oxoG)→8—oxoG与A配对→导致G：C→T：A颠换。

Objective: Design and synthesize the oligodeoxynucleotides containing unm- ethylated CpG dinucleotides to screen out the optimal CpG-ODN that could markedly enhance the immune function of cord blood mononuclear cells in health newborns. Moreover, observe the action of CpG-1826 (5'-TCCATGACGTTC CTGACGTT-3') as the immune adjuvant of the hepatitis B vaccine on the pregnant mice and their neonatal mice.

目的：设计并合成含非甲基化胞嘧啶和鸟嘌呤二核苷酸的寡聚脱氧核糖核苷酸，以期筛选出对新生儿脐血单个核细胞免疫刺激作用较强的CpG-ODN；观察不同剂量CPG-1826(5'-TCCATGACGTTCCTGACGTT-3')辅助乙肝疫苗免疫孕鼠及仔鼠的作用。

Taking Eremothecium ashbyii (abbreviated as Eaw95. 1) as the original strain, after Υ-ray mutation, tubercidin and 8--azaguaniae (8--AG) resistant tests, a strain labeled as T〓 capable of overproducing riboflavin was obtained and its genetic stability was analyzed. Compared with Eaw95. 1, the riboflavin productivity was improved about 40% by flask--shaking tests.

以Eremothecium ashbyii为出发菌（间称Eaw95.1），通过Υ-射线诱变，杀结核菌素和8-氮杂鸟嘌呤等结构类似物的的抗性筛选，获得了一株核黄素高产菌T〓，并对菌株的遗传稳定性进行了研究，获得了较好的效果，与出发菌株相比，核黄素的摇瓶发酵产量提高了近40％。

The repair of alkylation damage to the O6-position of guanine is performed by O6-alkylguanine-DNAalkyltransferase, whose expression is considerable variated among individuals.

MGMT 是人体内唯一能将 NNK 所致 O6-鸟嘌呤甲基加合物从 DNA 上移除，进行损伤修复的 DR 蛋白，但其表达在不同的个体中存在显著的差异。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。