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鳞状上皮细胞

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Objective To investigate the expression of ezrin in seborrheic keratosis, basal cell carcinoma, squamous cell carcinoma and its relation to clinical pathology parameters.

目的 探讨埃兹蛋白在脂溢性角化病、基底细胞上皮瘤、皮肤鳞状细胞癌中的表达及其与临床病理参数之间的相关性。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too. Overexpression of P53 protein was detected in 30/53 cases of basal cell carcinoma, 16/32 cases of squamous cell carcinoma, 10/17 cases of meibomian gland carcinoma, and the intensity of P53 protein immunostaining increased with the lowering in the degree of histological differentiation.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见P53蛋白表达,而中、重度不典型增生,原位癌,浸润癌中,P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞癌(basal cell carcinoma,BCC)、16/32例鳞状细胞癌(squamous cell carcinoma,SCC)、10/17例睑板腺癌中,P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低,P53蛋白阳性表达程度有逐渐增高的趋势。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见 P53蛋白表达,而中、重度不典型增生,原位癌,浸润癌中, P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞癌(basal cell carcinoma,BCC)、16/32例鳞状细胞癌(squamous cell carcinoma,SCC)、10/17例睑板腺癌中, P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低, P53蛋白阳性表达程度有逐渐增高的趋势。

Objective To explore the clinical pathological features,diagnosis and differential diagnosis of spindle cell myoepithelial carcinoma with lymph node squamous cell carcinoma metastasis.

目的探讨伴淋巴结鳞状细胞癌转移的梭形细胞肌上皮癌病理特征、诊断和鉴别诊断,提高对该肿瘤的诊断水平。

Myoepithelial carcinoma ; Squamous cell carcinoma ; Metastasis ; Lymph node ; Immunohistochemistry

肌上皮癌;梭形细胞;鳞状细胞癌;转移;淋巴结

Results Among16826 subject cases,1 case of squamous cell caroinoma has been found,2cases of CIN-3,12cases of CIN-2,and391 cases of CIN-1 have been found And among the found cases,there are263 caese of CIN-1 case of HPV infection;197cases of trichomonal infection;388cases of candidal infection,156 cases of bacterial infection .14410cases of inflammatory cell changing;2001 cases of ceriical intraepithelial neoplasia,8cases of ASC-US and1 case of AGUS.

结果 16826例标本中,发现1例鳞状细胞癌;2例CIN-3;12例CIN-2;391例CIN-1,其中263例 CIN-1HPV感染;滴虫感染197例;霉菌感染388例;细菌感染156例;有炎性反应性细胞改变的14410例;无上皮内病变或恶性瘤变的2001例;8例ASC-US;1例AGUS。

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