高脂血症

Objective To assess the current status in dietary treatment of hypercholesterolemia and its effects on control of this disease in China.

目的 了解接受调脂药物治疗的高胆固醇血症患者膳食状况及膳食对高胆固醇血症控制状况的影响。

ConclusionNew criteria of plasma lipid values in children in Beijing are established by our investigation in 971 healthy school students.Age and sex have been analyzed.Borderline and high of TC and LDLC levels have been settled.Cutoff of hypertriglyceridemia and hypohigh density lipoprotein cholesterolemia have also been established.

结论通过对971名北京市中小学生的血脂调查，建立了北京地区不同年龄性别儿童青少年的血脂正常值，确立了临界高胆固醇和高胆固醇血症浓度、高甘油三酯血症浓度和低高密度脂蛋白浓度。

The incidence rates of hyperlipemia,hypertension,diabetes,coronary heart discase,liver lipopexia in hyperuricemia group were sig-nificantely higher than that of normal group.

高尿酸血症组中高脂血症、高血压、高血糖、冠心病、脂肪肝等发生率显著高于血尿酸正常组。

The improved puberty PCOS-IR rat model has following characteristic:Retained the high androgen syndrome and/or the high LH syndrome as the endocrine characteristics;Simultaneously it had sugar fat metabolism unusual, such as the insulin resistance,the redemptive high insulin blood sickness as well as cholesterol ascension.Has the abdomen obese characteristic----In particular fat pad which around reproductive organ obvious increased;The ovary increased obviously,Ovarian cortex accumulated,the number in ovary pouch expansion graafian follicle were remarkable increased, ovulation suppression.

一、改良青春期PCOS-IR大鼠模型具有以下特征：1、保留了高雄激素血症和/或高LH血症等内分泌特征；同时有胰岛素抵抗，代偿性高胰岛素血症以及总胆固醇升高的糖脂代谢异常。2、具有腹部肥胖的特征——尤其是生殖器周围脂肪垫明显增加；3、卵巢明显增大，皮质增厚，卵巢内囊性扩张卵泡数目显著增加，排卵抑制。

VLDL can downregulate the expression of the hOAT1gene possibly induced by lipodystrophy easily acting with hyperuricemia.

VLDL可下调hOAT1mRNA的表达，可能与脂代谢紊乱易合并高尿酸血症有关。脂蛋白类，VLDL；尿酸；肾小管；细胞，培养的；基因表达

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

We investigated the effect of the known hypocholesterolaemic and anti-atherosclerotic drug probucol on serum lipids, lipoproteins and atherosclerosis in fat-fed low density lipoprotein receptor deficient mice.

本实验研究了抗高胆固醇血症和抗动脉粥样硬化药物普罗布考对脂肪饲养低密度脂蛋白受体缺失小鼠的血清脂质，脂蛋白和动脉粥样硬化的影响。

Uricase inhibitor was given subcutaneously by lanolin mixed with olefin in acute animal model with Hyperuricemia on rat, which has the characters of high uric acid and maintaining a long time.

以羊毛脂石蜡油（质量比3：2）为溶剂配制尿酸酶抑制剂，采用皮下注射的方法造模，所复制的大鼠代谢性高尿酸血症模型具有血尿酸值高、维持时间长的特点。

The effects of Lecithin on reducing LDL cholesterol and increasing HDL cholesterol makes it useful in the treatment of atherosclerosis, hypercholesterolaemia, hyperlipidaemia, Coronary heart disease and hypertension.

的影响，卵磷脂对降低低密度脂蛋白胆固醇，增加高密度脂蛋白胆固醇，使有益的，在缓解动脉粥样硬化，高胆固醇血症，高血脂症，冠心病及高血压。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。