高脂血

Methods Twenty-six NZW rabbits were randomly divided into three groups: a normal control group (fed on normal commercial rabbit diet, n =6), a hyperlipidemic group fed on high-fat ma total cholesterol (TC concentration at the beginning and the 12-week end point of the experiment determined,and all the experimental rabbits were sacrificed, and endothelial function test were performed on thoracic aortic rings prepared from the isolated aorta using the vascular endothelium-dependent relaxation parameter in response to acetylcholine The aortic atherosclerotic lesion expression of LOX-1 mRNA and protein were examined by RTPCR and Western blotting respectively.

方法新西兰大白兔随机分为正常对照组(普通饮食，6只)，高脂饮食组(高脂饮食，10只)及普罗布考组(高脂饮食+普罗布考200mg/kg·d，10只)。实验开始前及第12周分别耳缘静脉采血测定血清总胆固醇。第12周处死动物，取胸主动脉，制备离体胸主动脉环对乙酰胆碱的反应以检查内皮功能，RT-PCR与免疫印迹检测凝集素样氧化低密度脂蛋白受体-1(LOX-1)基因与蛋白质表达水平。

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

Logistic regression analyses found tha tnationality, FINS, Hypertriglyceridemia, Hypercholesterolemia,BMI,serum Leptin, hypercholesterolemia, hypertriglyceridemia, low HDL cholesterol, diabetes, hypertension occupation, like drinking broth and chicken soup may be the risk factors ,and eating muscle, drinking milk, may be the protect factors of primar y hyperuricemia.

Logistic回归分析发现喜欢吃精瘦肉类和乳制品为高尿酸血症的保护因素，而患有高甘油三脂血症、胰岛素抵抗、高胆固醇血症、从事商业工作、高血压、喜欢喝肉汤鸡汤者以腰臀比较大、血清Leptin浓度较高可能是原发性高尿酸血症的危险因素。

Compared with these of fat-fed group, the body weight, blood glucose levels after oral glucose and the glucose area under curve, 40min and 90min blood glucose levels after insulin injection subcutaneously and the glucose area under curve in the insulin tolerance test, the fasting serum insulin, insulin resistance index, serum cholesterol, triglyceride and lower density lipoprotein cholesterol decreased, the fasting serum leptin, high density lipoprotein cholesterol and C18:2 were significantly increased in N-6 PUFAs group.

n-6脂肪酸组从第1~10周体重均较高脂组明显减轻，糖负荷后血糖和糖耐量试验中葡萄糖曲线下面积、皮下注射胰岛素后40min、90min血糖及胰岛素耐量试验中葡萄糖曲线下面积、血清胰岛素、胰岛素抵抗指数、血清胆固醇、甘油三酯和低密度脂蛋白含量均较高脂组明显降低；血清瘦素水平、高密度脂蛋白、18碳2烯酸较高脂组明显升高。

Methods After hyperlipidemic rat models were set upby oral administration of high lipid emulsion,the rats were divided into seven groups: control group,sham group,model group,SCL 60,20,5 mg·kg-1 groups and 200 mg·kg-1 CDT group.

建立大鼠高脂血症模型，分为对照组、假手术组、模型组及SCL 60、20和5 mg·kg-1组以及200 mg·kg-1复方丹参片组。

Results Xuezhikangcould markedly decrease the level of triglyceride and serum total cholesterol in elderlypatients,especially triglyceride.Its effects were the same as other tatin drug.Afterobserving 8 weeks,no side effects were found in clinic and biochemistry.

结果 老年高脂血症患者服用血脂康，对降低甘油三酯和胆固醇疗效均显著，尤其是甘油三酯，与其它他汀类药物相似，未发现有明显的临床和生化毒副作用。

Tibolone plus "Geng'an ning" may protect endothelial cell against hypercholesterolaemia damage to arterial wall.

替勃龙联合补肾中药更安宁治疗能保护血管内皮细胞，对抗高脂血症对动脉管壁的损伤。

Methods: Wistar rats used were divided into normal control group an d hyp erlipemia group. The morphological changes of er ythrocytes were observed by SEM, and classified and counted.

Wistar大鼠分为正常对照组和高脂血症组，利用扫描电镜观察红细胞形态改变并计数分类。

Vascular obstruction of the microcirculation may be caused by fat emboli, related to hyperlipidemia associated with alcoholism, steroid therapy, SCD, and nitrogen bubbles in decompression sickness.

血管阻塞的微循环可能造成的脂肪栓子，与高脂血症与酗酒，类固醇治疗，猝死，氮泡沫减压病。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。