高尿酸尿症

Urinary NAG is a early Diagnostic indicator of renal damage in patients with hyperuricosuria, especially for gouty kidney.

提示尿NAG可作为高尿酸血症患者早期肾功能损害的观测指标，尤其对痛风肾的早期诊断有重要意义。

In the use of diuretics in the treatment of hypertensive patients, but also about 40% to 50% of people with hyperuricemia.

在使用利尿剂治疗的高血压患者中，也有约40％～50％的人伴有高尿酸血症。

In part 1, a practical one-step RP-HPLC method thatcan simultaneous determine hypoxanthine, xanthine, uric acid, allantoin and creatinine in blood and urine was established.

人类高尿酸血症多为肾脏排泄尿酸减少的类型，而现有的建模方法在升高血尿酸的同时，也使尿尿酸含量显著增高。

Objective: Investigating the clinical significance of early diagnosis of urate damage to the kidney of enzyme N-acetyl-beta-D-glucosaminidase determination in Patients with hyperuricosuria.

目的：探讨尿NAG活性测定对高尿酸血症患者尿酸盐晶体对肾损害的早期诊断。

To warn that patients are receiving this medication at the same time not to use the excretion of uric acid can inhibit the antihypertensive drugs, such as Thiazide diuretics, including thiazide-type diuretics, as well as the compound preparation of salicylic acid drugs Astemizole aspirin, etc.

需提醒的是，患者在服用此药物的同时，不宜使用可抑制尿酸排泄的降压药物，如噻嗪类利尿剂、含噻嗪类利尿剂的复方制剂以及水杨酸类药物，以防止高尿酸血症的发生。

This is because:① hypertension caused by macrovascular disease, microvascular disease, the body part can hypoxia, blood lactate levels, leading to uric acid by inhibiting renal tubular secretion, coupled with increased synthesis of uric acid in patients, renal clearance of uric acid will reduce the functionality;② some long-term use in patients with hypertension Thiazide diuretics, the result of hypovolemia, which was repeated absorption of uric acid, thus leading to hyperuricemia.

这是因为：①高血压引起的大血管病变、微血管病变，可使机体部分组织缺氧、血乳酸水平升高，导致肾小管分泌尿酸受到抑制，加之病人体内尿酸合成增加，肾脏清除尿酸的功能就会降低；②部分高血压患者在长期使用噻嗪类利尿剂后，造成血容量减少，致使尿酸被重复吸收，从而引起高尿酸血症。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。