高危

Its research area include: The study of gene-brain-behavior relationships in neurogenetic developmental disorders; Brain and behavioral development in normal and disease groups; Risk, interventions, and outcomes in neurodevelopmental disorders and at risk populations.

该中心的研究领域包括：神经遗传发育失调过程中的基因、脑和行为之间的关系；正常和疾病群体的脑和行为发育；对神经发育失调及其高危人群发病的风险、干预和结果的研究。

Methods Two hundred and twenty-two people at high risk for schizophrenia and 331 normal controls were assessed with 14 neuropsychological tests.

选用14项神经心理测验对222例精神分裂症高危个体及331名正常对照个体进行认知功能的评定与比较。

［Objective］To study the risk factors of neurosurgical postoperative intracranial infection.

目的］探讨神经外科手术后颅内感染的相关高危因素。

Innovative Results】Based on study on colorectal cancer screening in Xiacheng district,the results have showed that①The CRC screening in urban area based on guideline established by our units had the same good results as in rural area.High risk factors questionnaire investigation had important role in CRC screening and it can make up the shortcomings of iFOBT and detect nonbleeding lesions,especially precancerous lesions such as adenomas and polyps;②Each high risk factor was sorted according to sensitivity and specificity for the first time among natural population in city.

通过对下城区大肠癌筛查的研究①首次证明来自于中小城市农村的大肠癌筛查方案对城市社区自然人群与中小城市农村的自然人群一样具有较好的检出效果，证明了问卷调查对大肠癌筛查的重要作用，能弥补iFOBT不足，发现其不能检出的包括不出血病变，尤其是腺瘤、息肉；②首次在城市社区自然人群中对各高危项目根据诊断的敏感度及特异度进行了排序。

Explore the incidence and high risk factors of late-onset noninfectious pulmonary complications.

及迟发性非感染性肺部并发症的发病情况，发病的高危因素。

To investigate the high risk elements analysis of chronic graft versus host disease.Explore early diagnosis of late-onset noninfectious pulmonary complications.

研究目的慢性移植物抗宿主病是异基因造血干细胞移植后的主要并发症，探讨慢性移植物抗宿主病发病的高危因素，探讨迟发性非感染性肺部并发症的早期诊断，为临床有效防治cGVHD提供指导依据。

Increased seerity of heart failure or increased number of concomitant medications did not worsen persistence, but nonpersistence identified a high-risk population of patients who required special attention.

心衰恶化或治疗药物数量的增长并不使持续治疗的比例减少，但在高危病人中没有持续治疗值得特别关注。

objective to study the risk factors on esbl producing strains of k.pneumoniae and e.coli.methods aprospective survey on esbl producing strainsof k.pneumoniae and e.coli for a36-month period.results the resistance rates ofe.coli were:98.08%for ctx,73.08%for amc.the resistance rates of k.pneuˉmonialwere;95.74%for ctx,97.87%for amc.the use rate of third generation cephalosporins was much higher than those of esbls nonproducing strains（p.05）.it induce esbls that3rd generation cephalosporins were used extensive.after strenghtening the antibiotic controls,esbls detection rate has gone down.conclusion the factors of infection of esbl-producing strains were the severity diseases,cellular immunological condition,improper medical manipulations.to prevent esbl-producing strains,reasonable antibiotics usage may be the effective measure.

目的 分析临床大肠埃希菌及肺炎克雷伯菌产esbls的危险因素，并加以控制。方法前瞻性监测产esbls菌的情况，并对感染者进行临床调查。结果产esbls的大肠埃希菌、肺炎克雷伯菌的耐药率头孢噻肟钠为98.08%和95.74%，阿莫西林+棒酸为73.08%和97.87%，产esbls菌感染者头孢第三代的使用率（70.21%）显著高于非产esbls菌感染者（39.47%）（p.05）；第三代头孢的大量使用诱导esbls的产生。通过加强抗感染药物的使用管理esbls检出率开始下降。结论严重的基础病、高龄、机体免疫力低下，长期住院者是esbls菌感染的易感宿主，皮质激素、化疗及介入性疗法是esbls感染的高危因素。滥用抗感染药是产生esbls的重要因素，合理使用抗感染药是防止esbls产生的主要措施。

Previous researches indicated that patients of young or premenopausal age, nonspecial type invasive carcinoma, highly malignant histological degree, advanced tumor stage, negative hormone receptor status and without standard adjuvant therapy would increase the recurrent and metastastic risk of breast cancer after surgery.

既往研究表明，年轻或绝经前患者、浸润性非特殊类型癌、组织学分级恶性程度高、肿瘤分期较晚、激素受体阴性、未进行标准的辅助治疗等均是乳腺癌术后复发转移的高危因素。

Fetal surveillance with tests eg, BPS, nonstress test

具有胎儿窒息高危因素的孕妇应进行产前胎儿监护试验（如生物物理评分，无应激试验

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。