髓鞘质的

Methods Proteins and peptides in CSF were separated by two-dimensional gel electrophoresis（2DE） and ultra-performance liquid chromatographer and identified by matrix assisted laser desorption ionization time of flight mass spectrometry（MALDI-TOF-MS） and electrospray ionization to study differential proteomic expression in the cerebrospinal fluid between patients with Demy- elinative disease and with other neurological diseases.

方法以中枢神经系统脱髓鞘疾病患者的脑脊液为研究对象，分别采用固相pH梯度双向凝胶电泳分离总蛋白质，凝胶经银染显色后，用图像分析软件进行比较分析、识别差异表达的蛋白质，离线应用基质辅助激光解析电离飞行时间质谱得到相应的肽指纹图谱；同时用超高压液相色谱分离酶解肽段，在线采用电喷雾四极杆飞行时间质谱鉴定肽段氨基酸序列；搜索数据库鉴定部分蛋白质。

Results: electronic microscope showed that in prednisone group heterochromatin increased in some cells, entoblast was not obvious in some cells, fat drops were small and few, mitochondria vacuole were common, and myelin figure was found in smooth endoplamic reticulum. the ultrastructure in yc group was almost normal and megamitochondrion formation was common. a large amount of fat drops were found in cytoplasm in gw group and little improvement was found compared with that in prednisone group.

结果： 电镜结果显示：激素组个别细胞异染色质增多，核仁不明显，脂滴显著变小变少，线粒体空泡化常见，有滑面内质网髓鞘样结构形成；养阴组电镜结构基本正常，其特征是细胞内有较多的巨大线粒体形成；桂附组较激素组改善不明显，其特征是胞质内可见大量脂滴。

SCI can cause hematomyel ia, dropsy, necrosis, capsular space, gummosis and so on, which can lead to neuron deprivation, demyelination of neurite. Clinical symptoms mainly manifest funct ion disorder of movement, sense, reflectance, and musculus sphincter below injury plan.

SCI后出现脊髓出血、水肿、坏死、囊腔形成、退变胶质化等一系列病理改变，以致神经元丧失、轴突脱髓鞘，临床表现为受损平面以下的运动、感觉、反射及括约肌功能的障碍。

Results One case with infantile onset had macrocephaly. The CT scan and MRI showedprominent low-density white matter throughout the cerebral hemispheres. MRI showed prominent also increased T2 signal in the periventricular whitematter. Another patient had an onset at school-age. The CT scan demonstrated brain atrophy. Histological examination on brain biopsy revealed diffuse demyelination and fibrous gliosis.

结果1例婴儿期起病者头颅大，CT扫描示前额明显的广泛性脑白质密度减低特征，MRI示脑室旁白质T2高信号；另1例学龄期起病，CT扫描显示脑萎缩，脑活检光镜下发现脱髓鞘和胶质细胞增生，电镜下观察到大量Rosenthal纤维及不规则的颗粒状沉积物。

The nitric oxide produced by the glial cells might play a key role in the process of EAE in regard to the destruction of the blood-brain-barrier in the early stage and the myelin and the oligodendroglia in progressing stage.

提示一氧化氮是EAE早期血脑屏障破坏以及进展期髓鞘和少突胶质细胞破坏的重要介导物质。

The stage of neuron development during which many axons become myelinated by glial cells .

神经胶质细胞造成轴突髓鞘化这段期间的神经元发展阶段。

Lipid peroxidation would cause the deficiency of myelinogenesis, Dysfunction of synaptic conduction and developmental anomaly of nerve cell if the deficiency of completely.

当硒缺乏时，硒蛋白活性降低，清除H2O2能力减弱，脂质过氧化导致髓鞘形成不良，突触传导障碍，神经元发育异常，造成严重的脑功能紊乱。

Human neurotropic JC virus is able to infect human brain glial cells. The causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy, that cytolyses and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Also results from several experiments have indicated the JCV is able to induce neoplasms.

人类嗜神经性JC病毒可感染人类脑细胞是引起进行性多病灶脑白质病的因素，为一种致命性的脱髓鞘疾病，其导致神经系统产髓质细胞的溶解破坏，但JCV也在许多动物实验上显示其有促成肿瘤的潜在性。

Electronic microscopic observations showed that the swollen mitochondria with cristae blurred appeared in some pyramidal cells. Some pyramidal cells showed degenerative changes with some disappeared endoplastic reticula and ribose nuclear protein and increased lysosomes. The amount of extends endothelial projections going to the lumen of capillaries were increased.

同时伴有超微结构的改变，如神经细胞线粒体肿胀，内质网扩张，染色质凝集成块状，毛细血管外间隙扩大，髓鞘变性坏死，微管排列紊乱，小胶质细胞有吞噬变性坏死的神经纤维成分等。

But there are a lot of disadvantage factors clagging the neurogeneration, such as the myelin-relative inhibitor, the information of glial scar and immune repulsive reaction.

关于干细胞及营养因子在损伤脊髓修复方面的研究虽已取得较大进展，但仍存在对神经再生的不利因素，如髓鞘相关抑制分子和胶质瘢痕形成，免疫排斥等。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。