髓突

Objective to evaluate the functional recovery of acute spinal cord injuried rats treated with exogenous wnt-3a signal protein administration and to explore its mechanism.methods moderate spinal cord contusion injury was made in 40 adult sprague dawley rats at t10.twenty rats served as contusion controls(group 1).twenty rats were treated with wnt-3a for three days after injury (group 2).the functional recovery of the rats was observed through basso,beattie,bresnahan open field locomotor score.rats were killed at 14 or 28 days after injury,then spinal cords were removed for histopathological examinations,and the expression of the bromodeoxyuridine plus neural cell markers was stained with immunohistochemical method.results rats of two groups receiving a contusive injury recovered substantial function within 1 week.by 28 days,rats in groups 2 scored 7.0 points better on the bbb scores than rats in group 1 group 2=16.94,after 28 days vs.

目的 研究外源性wnt-3a信号蛋白对脊髓损伤的修复作用，并探讨其作用机制。方法取40只成年雌性sd大鼠在t10节段制备适度脊髓挫伤模型。随机从中取20只为损伤对照组(group 1)，另外20只为损伤治疗组(group 2)。脊髓损伤3天后用wnt-3a蛋白治疗。这些大鼠的功能恢复通过basso、beattie、bresnahan开放视野运动评分来观察。这些大鼠分批在损伤后14天或28天被处死，取出损伤节段脊髓用来组织病理学检查，同时用5-溴脱氧尿嘧啶核苷和神经细胞标记物进行免疫组化染色。结果两组大鼠在伤后一周运动功能有明显的恢复。不过，到损伤后28天，我们观察发现，损伤治疗组中的大鼠bbb评分比损伤对照组中的评分高出7.0分左右(group 2∶16.94±1.18，group 1∶9.89±1.29；p.05)，光镜和电镜检查发现wnt-3a蛋白对髓鞘形成和轴突再生有一定的修复效果。

A synapse is a junction between the axon and dendrites of two neurons.

许多神经元内的轴突被包裹在髓鞘内。

RESULTS: The fibers of optic nerve projected to the dorsomedial side of suprachiasmatic nucleus and the fibers of hypoglossal nerve projected on the hypoglossal nucleus on dorsomedial portion of the medulla oblongate.

结果：视神经纤维投射到视交叉上核背内侧；舌下神经纤维投射到延髓背侧的舌下神经核区，结果显示神经元的胞体和轴突结构清晰。

The structure of axon was completed, and the arrangement of regenerated nerve fibers with rotund or elliptoid shapes was closed.

电镜超微结构观察可见再生的神经纤维较粗大，排列紧密，呈均匀一致圆型或椭圆型，髓鞘较厚，轴突结构完整。

Results. Five patients with HLDs underwent partial hemilaminectomy and discectomy during pregnancy and maintained the pregnancy.

研究结果：其中患有腰突的5位患者在怀孕期间接受了部分髓核摘除术和椎间盘全摘术并且未影响生育。

The spinal column reconstruction in the interspinal implants in thing X-stop finite element analysis application Abstract along with people age unceasing growth, between awl in plate the nucleus pulposus gradually will start to degenerate withered, causes between the awl plate thickness to reduce, will then create the yellow ligament and the small surface joint is large, will initiate the so-called lumbar vertebra narrow sickness, will cause the body to have the nerve intermittent slope good symptom.

脊柱重建在棘突间植入物X-stop有限元分析中的应用摘要随着人们年龄的不断增长，锥间盘里的的髓核就会逐渐开始干枯退化，造成锥间盘厚度减小，进而造成黄韧带和小面关节肥大，以至于引发所谓的腰椎狭窄症，造成身体产生神经间歇性坡行症状。

A case report was presented with a female patient of class II malocclusion, bimaxillary dentoalveolar protrusion with space deficiency. Bilateral lower left second molars were mesially inclined impactions with large caries. The lower left second molar was diagnosed with acute apical periodontitis.

本文提出一双颚齿槽前突合并齿列拥挤之安格氏二级咬合不正之女性患者，其下颚两侧第二大臼齿为近心倾倒之阻生齿合并龋齿，而左下第二大臼齿之龋齿已侵犯到牙髓而有急性根尖牙周炎的情况。

The stage of neuron development during which many axons become myelinated by glial cells .

神经胶质细胞造成轴突髓鞘化这段期间的神经元发展阶段。

Lipid peroxidation would cause the deficiency of myelinogenesis, Dysfunction of synaptic conduction and developmental anomaly of nerve cell if the deficiency of completely.

当硒缺乏时，硒蛋白活性降低，清除H2O2能力减弱，脂质过氧化导致髓鞘形成不良，突触传导障碍，神经元发育异常，造成严重的脑功能紊乱。

Results: ApoD was observed positively expressed in type2 astrocytes and oligodendrocytes from O2A lineage, while it was not expressed in type1 astrocytes from T1A lineage. Accordingly, we can verify the phenomenon found in the study of T1A and T2A gene different expression profile that ApoD mRNA was highly expressed in T2A and lowly expressed in T1A. Conclusion: It can be concluded that lipid metabolism related genes such as ApoD play important roles in the generation and differentiation of O2A lineage, which closely correlate with internal mechanism of lipid metabolism in the brain and myelogenesis.［Key words］astrocyte(T1A, T2A); oligodendrocyte; O2A lineage; apolipoproteinApoD

我们已采用基因芯片技术在mRNA水平研究两型星形胶质细胞的基因表达谱差异，发现ApoD在2型星形胶质细胞中差异高表达，故本文拟用激光共聚焦双重免疫荧光标记技术进一步在蛋白质水平观察ApoD在体外分化成熟的两型星形胶质细胞以及少突胶质细胞中的表达情况，以期为我们深入研究ApoD等脂代谢相关基因在脑内脂质代谢和神经髓鞘发育机制中所起的作用提供有用的实验依据，依此探讨胶质细胞发生和分化的信号机制。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。