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Posterolateral Lumbar Intertransverse Process Spinal Arthrodesis With Composites Composed Of Recombinant Human Bone Morphogenetic Protein 2 And Allograft Or Xenograft; Or With Composite Consisted Of HA And Xenograft in rabbitsBackground: So far spine arthrodesis remains to be used in spine surgery.

中文题名rhBMP-2、HA及其复合物在兔腰椎后外侧融合的实验研究副题名外文题名论文作者杨发军导师马忠泰教授学科专业外科学研究领域\研究方向临床技能训练与研究学位级别博士学位授予单位北京大学学位授予日期2001 论文页码总数92页关键词骨形态发生蛋白异体骨移植脊柱融合异种骨移植馆藏号BSLW /2001 /R687 /42 背景:目前,脊柱融合手术被广泛地应用于脊柱外科领域,自体髂骨仍是被最常用的骨移植物,但是其有5%-35%的不融合率。

The third line is called the intertubercular, and runs across between the two rough tubercles, which can be felt on the outer lip of the crest of the ilium about two and a half inches (60 mm) from the anterior superior spine.

第三条线为结节间线,在两粗大的结节间走过,位于髂骨嵴的外唇,离髂前上棘大约2.5寸(60 mm)处。

Magnetic resonance imaging of MR-MSCs represents a method for noninvasively tracking the quantity and location of intramyocardial delivery in myocardium.

方法抽取猪髂骨骨髓,密度梯度离心后获取单个核细胞层,以差时贴壁的方法纯化培养骨髓间充质干细胞。

In the control groups, both types of bone graft presented significant resorption both at 5 and at 11 months with the ischiac bone grafts presenting more resorption in width and length than the calarial bone grafts.

在对照组,两种骨移植物在第5月及第11月均表现显著的吸收,吸收程度相似,而髂骨移植物在宽度和长度上吸收的比颅骨移植物更为显著。

At one side of the jaw, a calarial bone graft (baseline 3 4 0.64 mm) was placed at the inferior border of the mandible and was fixed with a standardized screw-type titanium microimplant. At the contralateral side, an ischiac bone graft (baseline 3 4 0.87) was transplanted. The healing period was 5 months.

将这些小鼠分为4组(A5,A11,B5,B11)。A5组:暴露双侧下颌骨下缘,在一侧下颌骨下缘用标准化微型钛螺钉固定3*4*0.64mm的颅骨移植物,在对侧固定3*4*0.87mm的髂骨移植物。

Site complications have been reported, including pain, infection, meralgia paresthetica and pelvic fracture, and neurovascular injury [9]. The overall complication rate for iliac crest harvest varies within the literature.

自体髂骨植骨一直以来都应用于ACDF,报道有大量的供区并发症,包括疼痛,感染,感觉异常性股痛,和骨盆骨折,神经血管损伤。

Key words: Monte Carlo method; MIRD method; ^153Sm-EDTMP; Absorption dose

患者注射153Sm-EDTMP 33.6×37 MBq,左髂骨转移病灶最高吸收剂量约为5.6 Gy,病灶边缘的吸收剂量为2.0 Gy,以病灶区最高剂量点为参考点,则椎体、皮质、骨髓、脊髓和盆腔组织仅相当于最高剂量的37%、12%、13%、21%和2%;MIRD方法的计算数据仅能粗略提示全身红骨髓吸收剂量,为2.39 Gy。

[Objective] To analyze the outcome of internal fixation for occipitalization with atlantoaxial joint dislocation by posterior decompression and occipitocervical fusion [Method] From December 2005 to June 2007,8 patients with occipitalization and atlantoaxial joint dislocation received removal of the posterior arcus of atlas and the enlargement of the posterior edge of the foramen magnum after skull traction performing for an average of 135 daysAll patients were operated on by posterior craniocervical fusion using cervifix internal fixation system and autologous ilium graftsThe clinical efficacy after operation was analyzed by Japanese Orthopaedic Associationneural function score [Result] All the patients were followed up from 6 months to 2 years, average of 15 monthsNo complication was foundAtlantodental interval was 5~9 mm before and 4~6 mm after skull tractionAtlantoaxial joint dislocation didn't completely reducedThe neurological defects were improved to some extents according to the JOA scoreImageology showed all patients had full decompression and bony fusionThe loosening or broken internal fixation was not found [Conclusion] Posterior decompression and fusion is a feasible method for the treatment of occipitalization with atlantoaxial joint dislocation,and the clinical effect is satisfactory

分析后路减压枕颈融合内固定术治疗合并寰枢关节脱位的寰椎枕骨化临床疗效。[方法]2005年12月至2007年6月间,对8例合并寰枢关节脱位的寰椎枕骨化患者在行颅骨牵引治疗一段时间(12~16 d,平均135 d)后采用枕骨大孔后缘扩大,寰椎后弓切除减压取自体髂骨枕颈融合Cervifix系统内固定术,手术后采用日本骨科学会神经功能评分分析临床疗效。[结果]8例患者随访6个月~2年,平均为15个月。8例患者无一例出现术后并发症,术前寰齿前间隙为5~9 mm,经颅骨牵引后为5~7 mm,寰枢关节脱位未能完全复位。手术前后JOA评分示神经症状均有不同程度恢复,影像学检查示枕颈区减压充分植骨区获得骨性融合,无一例出现内固定松动或断裂。[结论]合并寰枢关节脱位的寰椎枕骨化患者术前仔细评估影像学改变,采用颅骨牵引一段时间后行后路减压枕颈融合内固定术的治疗方案是合理可行的,且临床效果满意。

Methods BMSCs isolated from rabbit iliac bone marrow were culture-expanded in vitro. The injectable tissue-engineered bone constructed from autologous PRP, FG, and BMSCs was cultured in vitro, and its biological characteristics were observed including the time of gel formation, histological features, seed cell survival and microscopic structures. Results The constructed injectable tissue-engineered bone began gel formation within 20 to 30 s, and after a week-long culture, the gelatine began to degrade, and numerous well viable fusiform cells could be seen to adhere to the bottom of the Petil dish, Scanning electron microscopy identified globular and olivary cells embedded in the fibrin glue, and numerous small particles could be seen around of the cells.

从兔髂骨处抽取骨髓体外培养BMSCs并诱导向成骨细胞分化,抽取兔自体动脉血提取PRP,以FG、BMSCs、PRP共同构建可注射型组织下程骨并体外培养观察其生物学特性如凝胶形成时间,组织学特点、细胞存活情况及其超微结构特征等结果构建的可注射型组织工程骨可在短时间内形成凝胶,体外培养1周时其中细胞生长良好,电镜下见纤维蛋白网格结构致密,种子细胞及血小板颗粒分布广泛。

PART II: Twenty-eight mandiblular reconstructions were performed for oncologic defects, and their cases were studied.

结果表明:VEGF和MMP—9参与调节自体髂骨移植愈合中的骨改建和修复。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

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