骨髓腔

BACKGROUND: Osteoblasts derived from bone marrow stromal stem cells are the main force of the cells in bone marrow cavity. In the artificial joint replacement cases, their life situation is closely related to conductive pressure of prosthesis.

背景：骨髓基质干细胞来源的成骨细胞是骨髓腔内主要的受力细胞，在人工关节置换病例中，其生命活动状况与假体传导压力有密切关系。

It is suggested that the fetal liver cells injected into the bone marrow cavity can settle down and proliferate here and the volume of injection should be limited.

这一研究结果说明，直接注入骨髓腔内的胎肝细胞，能在骨髓腔内定居、增殖，实验结果还提示，用骨髓内注射法进行造血细胞移植时，注入骨髓腔内的细胞悬液量不宜太多。

Aseptic loosening of prosthesis has become the main reason for failure. From the prospect of prosthesis design,increasing the prosthesis and bone adaptation to reduce the initial micromotion and increase long term bone ingrowth is the only way to achieve long term fixation.

而这一密合程度由髓腔形态与假体外形共同决定，因此股骨髓腔形态必须纳入假体设计的考量的中，而研究各种影响髓腔形态的因素就极具价值和意义。

Results The total length of femur medullary cavity were (33.51±0.63)cm and (33.13±0.64)cm; the length of the narrow point were (5.61±0.49)cm and (5.17±0.46)cm; the narrowest part were located on the proximal end of medullary cavity the distance of them were (3.55±0.15)cm and (3.52±0.27)cm; the sagital diameter were longer than the coronal diameter of the narrow point medullary cavity, the front one were(1.215±0.113)cm and the other one were (1.077±0.116)cm; the arc semidiameter of medullary cavity were(120.608±6.089)cm.

结果 股骨骨髓腔全长为(33.51±0.63)cm和(33.13±0.64)cm；狭窄段长度为(5.61±0.49)cm和(5.17±0.46)cm；髓腔最狭窄点位于髓腔中点近侧，距离为(3.55±0.15)cm和(3.52±0.27)cm，狭窄点髓腔矢状径较冠状径大，分别为(1.215±0.113)cm 和(1.077±0.116)cm，髓腔弧度半径为(120.608±6.089)cm。

Full-thickness articular cartilage defects (diameter: 3mm, depth: 3mm) were made to bilateral condylus medialis femoris of all rabbits. In periosteum+BMSCs group and periosteum group, defects were covered by homolateral autogenous proximal tibia periosteums, with germinal layer facing to cavitas medullaris. After that, the periosteum+BMSCs group received 3 sutures, followed by injection of 20 μL BMSCs suspension (1×109/L) into the defects, after which the last suture was taken.

在全部兔双侧股骨内侧髁造成直径3 mm，深度3 mm的全层软骨缺损，骨膜复合骨髓间充质干细胞组、单纯骨膜组取同侧胫骨上段内侧骨膜，骨膜生发层朝向骨髓腔覆盖软骨缺损，骨膜复合骨髓间充质干细胞组先期缝合3针，向缺损区注入1×109 L-1骨髓间充质干细胞细胞悬液20 μL，植入细胞后缝合最后1针。

All the animals were divided into 3 groups of 21 each randomly: 1 Kirschner wire group: Intramedullary Kirschner wires were made as inner fixation. 2 CPC group: Injectable CPC single was injected into medullar through 9# needle. The fracture parts were holded by hands until CPC harden. 3 CPC-BMP group: treated as CPC group but substituted the composite of CPC/rhBMP-2 for CPC.

随机分成3组，每组21只：1克氏针组，从髁间窝穿入直径1mm克氏针固定；2CPC组，将CPC从9号针头注入骨髓腔，手法固定至骨水泥凝固；3CPC-BMP组，将CPC与rhBMP-2复合材料用9号针头注入骨髓腔，手法固定至骨水泥凝固。

According to the third rotator, neck of femur of rabbits was not broken off;meanwhile, lateral part of greater trochanter was sawed up above the third rotator, entrance of medullary cavity of bone was found among fossas of rotator, and bone cement was perfused into left femoral medullary cavity by blocking of proximal and middle femoral medullary cavity with polymethyl methacrylate to establish the rabbit model.

取大白兔16只，根据兔存在有第3转子这个特殊的解剖结构，采用不打断股骨颈，在第3转子上方横行锯掉大转子外侧部分，在转子间窝找到骨髓腔入口，左侧股骨髓腔内灌注骨水泥，建立单纯以聚甲基丙烯酸甲酯骨水泥阻塞骨干髓腔的兔动物模型。

Blood production - The marrow, located within the medullary cavity of long bones and the interstices of cancellous bone, produces blood cells in a process called haematopoiesis.

造血－骨髓位于长骨髓腔和松质骨间隙内，骨髓通过造血作用产生血细胞。

L Blood production — The marrow, located within the medullary cavity of long bones and the interstices of cancellous bone, produces blood cells in a process called haematopoiesis.

l 造血－骨髓位于长骨髓腔和松质骨间隙内，骨髓通过造血作用产生血细胞。

In addition, many studies of patients with AVN showed plenty of special characteristics,such as age distribution and bone quality.Objective:To study the geometric features of proximal femur for the Chinese AVN population,in order to prove the existence of special characteristic of proximal femur for the disease and then develop an AVN-specialized stem evaluated by a validated finite element analysis.Methods:1.The author investigated the standard X-ray data of 127 cases(179 hips) with definite diagnosis of AVN to provide anatomical references for this disease.At the same time,we conducted a meta-analysis of anatomical studies of normal proximal femur data,including the section of LT+20,LT,LT-20 and CFI to identify the potential difference between AVN and normal population.

方法1、通过研究AVN患者标准X线正、侧位片127例(179髋)，获得股骨近端的解剖学数据，利用荟萃分析的方法比较AVN患者股骨近段髓腔特征平面(LT+20，LT，LT-20)及CFI的改变与以往研究数据的差异，并利用创伤性FNF患者资料代替正常人股骨数据进一步比较髓腔前、后、内、外四条曲线段上的差异。2、通过结合现代CAD技术，将内、外、前、后曲线拟合到AVN柄的外形上，选用短柄假体设计，近段设计利用AVN患者骨髓腔CT相对应位置的断面进行修正，设计AVN人工股骨柄。3、计算机三维有限元分析：①使用CAD软件SolidWorks和有限元软件Ansys所建立的髋关节股骨侧假体置换后的三维有限元模型。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。