骨髓白细胞

Results: The results showed that SMI had inhibited action on sweat, chill, spirit sag, especially had therapeutic effects on leucocytopenia in peripheral blood and reduces of nucleus cells in bone marrow induced by irradiation of 60Co -ray.

结果：SMI对~(60)Co照射所致小鼠血虚证症状如虚汗多、寒战、精神萎靡有一定程度的抑制作用，尤其对~(60)Co照射所致小鼠外周血白细胞和骨髓有核细胞数的减少有明显对抗作用，与模型组比较有显著性差异(P＜0.05)。

Results: The extract of propolis had certain antineoplasm effect and the inhibition rate of propolis extract on tumor is 27.74％ and when combined with cyclophosphamide, the inhibition rate reached to 50.32％, even antagonized leucocytopenia caused by cyclophosphamide.

结果：蜂胶提取物的抑瘤率为27.74％，与环磷酰胺合用的抑瘤率为50.32％，比单用蜂胶提取物及环磷酰胺分别提高22.58％和9.03％(P＜0.05)，并能减轻环磷酰胺所致的骨髓造血功能抑制，使血液白细胞维持在正常水平(P＜0.01)。

Methods Four patients with chronic myeloblastic leukemia and 4 with acute myeloid leukemia received allo-BMT with graft from 1 - 3 HLA-mismatched related donors.

方法4例慢性粒细胞白血病和4例急性髓性白血病患者接受人类白细胞抗原1-3个位点不相合骨髓移植，用阿糖胞苷、环磷酰胺和全身照射或马利兰进行预处理。

Results:The main clinical features including fever ( 86.7%), lymphnode enlargement( 66.7%), weight loss(40.0%), fungal infection (40.0%), leucopenia ( 53.3%), normocytic and normochromatic anemia(80.0%), thrombocytopenia(40.0%).

结果 ：15例患者中发热 13例( 86 。7%)，淋巴结肿大 10例( 6 6 。7%)，消瘦 6例( 4 0 。0 %)，真菌感染 6例( 4 0 。0 %)，白细胞减少 8例( 5 3.3%)，贫血 12例( 80 。0 %)，为正常细胞正常色素性贫血，血小板减少 6例( 4 0 。0 %)，骨髓有核细胞增生、浆细胞增多及病态造血，免疫学检查主要为细胞免疫缺陷。

Monocytes generated from bone marrow of Balb/cj mouse were cultured for 6 days in complete RPMI 1640 medium containing 10％ FBS, rmGM-CSF and rmIL-4.50 mg·L-1 acteoside or isoacteoside was added to cells on day 6 of culture for 24 h.The surface molecules expression level of DCs and their phagocytose ability were analysis by flow cytometry.

采用细胞因子诱导法，从Balb/cj小鼠骨髓细胞贴壁分离获得单核细胞，加入含10%胎牛血清、10 μg·L-1重组小鼠粒细胞巨噬细胞集落刺激因子及重组小鼠白细胞介素-4(rmIL-4)的RPMI 1640完全培养基培养，在培养第6天，实验组加入车前子苯乙醇苷类化合物(10，50，100 mg·L-1)，对照组加入RPMI 1640或LPS(1 mg·L-1)，流式细胞仪检测DCs表面分子CD11c，CD86，MHC II和CD80的表达以及各组DCs吞噬功能的变化。

Micronuclei in the bone marrow polychromatophilic erythrocytes in each dose group of mice were examined,leucocytes number and 30 day survival rate of mice following whole-body 5.0?Gy γ irradiation were also determined.

通过照射前后给予受试物，检测各剂量组受照小鼠的白细胞数、骨髓嗜多染红细胞微核数，观察照射后30d的平均存活天数。

Topotecan is an effective agent for SCLC when used as monotherapy or in combined treatment, but myelosuppression such as leucopenia and thrombopenia was relatively severe. Although it has been recommended as a second-line agent for recurrence of sensitive SCLC, more clinical trials are needed to define its role in first-line treatment.

拓扑替康治疗小细胞肺癌有确切临床疗效，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，但具有相对高的致白细胞和血小板下降的骨髓毒性，已被认为是治疗化疗敏感的小细胞肺癌患者复发的二线推荐药物，但是作为一线用药仍然需要更多的实践来证实。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

Meta-analyses showed that the response rate of TP (topotecan + cisplatin) regimen had no significant difference compared with EP regimen (etoposide + cisplatin) with OR 0.83 and 95%CI 0.63 to 1.09, but myelo-suppression such as leucopenia and thrombopenia was more severe with TP regimen; the response rate of monotherapy with topotecan was similar with that of CE (carboplatin + etoposide) regimen with OR 0.59 and 95%CI 0.22 to 1.60; the response rate of TEP (topotecan + etoposide + cisplatin) regimen was comparable with that of EP regimen with OR 1.37 and 95%CI 0.82 to –2.28, but myelosuppression and anemia were more severe with TEP regimen; the response rate with OR 0.97 and 95％CI 0.60 to –1.57, median time to progression with WMD –2.32 and 95％CI –5.72 to 1.09 and median survival time with WMD –1.65 and 95％CI –7.13 to 3.83 of IV topotecan were similar to those of oral topotecan, while neutropenia was more severe with IV topotecan.

Meta分析结果表明，TP 方案与EP方案的反应率相似 [OR 0.83， 95%CI (0.63，1.09)]，但具有相对高的致血小板下降的骨髓毒性；单药拓朴替康与CE方案的反应率相似 [OR 0.59， 95%CI (0.22，1.60)]；TEP方案（拓扑替康＋足叶乙甙＋顺铂）与EP方案的反应率相似 [OR 1.37， 95%CI (0.82，2.28)]，TEP方案致化疗后重度白细胞下降、重度血小板下降、重度血红蛋白下降均高于EP方案；口服拓扑替康与静脉滴注拓扑替康的化疗后反应率 [OR 0.97， 95％CI (0.60，1.57)]、中位疾病进展期 [WMD –2.32， 95％CI (–5.72， 1.09)]、中位生存期 [WMD –1.65， 95％CI (–7.13，3.83)] 相似，口服拓扑替康化疗后重度中性粒细胞下降明显低于静脉滴注拓扑替康。

In AML,monocytic leukemia is easier to become into HAL than other leukemias. In ALL,T-lineage antigens of HAL group are more easily expressed than those of NHAL group; the leukemia cells of HAL group are naiver than those of NHAL group,meanwhile the prognosis of HAL is poor. http://www.44dx.com

HAL比NHAL骨髓受抑程度更重，AML中单核细胞性白血病发生高白细胞性白血病的可能性高，ALL中HAL比NHAL更易于表达T系抗原，HAL的白血病细胞较NHAL处于更早分化阶段，同时HAL预后不佳。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。