骨髓淋巴细胞

Results In those patients with marrow invasion , 4 cases in I phase（4.2%）,12 cases in II phase（12.6%）,36 cases in Ⅲ phase（37.9%）and 43 cases in Ⅳ phase(47.4%);small lymphocytic、diffuse cleaved cell、lymphoblastic lymphoma are main pathologic types;patients with mediastinal lymphadenectasis、splenomegaly and spleen violations are prone to catch bone marrow involvement;56 cases of anemia in patients with bone marrow involuement(58.9%), 42 patients with thrombocytopenia (44.2%),27 cases with leukopenia (28.4%),49 cases of patients leukocyte increased (51.6%),so,anemia is common;three were 30 cases with three items abnormal（31.6％）and 65 cases with one item abnormal at least (68.4%),the incidence of abnormal peripheral blood in leukocythemia patients were higher than that in patients with bone marrow infiltration,Particularly the patients with increased leukocyte or three items abnormalities were more common in leukemia; Abnormal cells in peripheral blood were observed in 66 cases (69.5%); chemotherapy efficiency reached 65.2% in the patients with bone marrow involuement,the median survival time was 11.5 months.

结果发生骨髓侵犯病例中I期4例（4.2%）， II期12例（12.6%），Ⅲ期36例（37.9%），Ⅳ期43例(47.4%)；病理类型以小淋巴细胞性，弥漫型裂细胞性（改为：弥漫性大B细胞型淋巴瘤）和淋巴母细胞性淋巴瘤多见；纵隔淋巴结肿大、脾脏肿大和脾受侵患者易发生骨髓侵犯；骨髓侵犯患者外周血中贫血56例(58.9%)，血小板减少42例(44.2%)，白细胞减少27例(28.4%)，白细胞增高49例(51.6%)，以贫血多见；三项均异常30例(31.6%)，至少一项不正常65例(68.4%)，淋巴瘤细胞白血病患者外周血象异常发生率高于骨髓浸润患者，尤其是白细胞增高或三项均异常者更常见于白血病；66例(69.5%)外周血分类中发现异常细胞；骨髓侵犯化疗有效率65.2%，中位生存期11.5个月。

Results In those patients with marrow invasion , 4 cases in I phase（4.2%）,12 cases in II phase（12.6%）,36 cases in Ⅲ phase（37.9%）and 43 cases in Ⅳ phase(47.4%);small lymphocytic、diffuse cleaved cell、lymphoblastic lymphoma are main pathologic types;patients with mediastinal lymphadenectasis、splenomegaly and spleen violations are prone to catch bone marrow involvement;56 cases of anemia in patients with bone marrow involuement(58.9%)恶性淋巴瘤症状, 42 patients with thrombocytopenia (44.2%),27 cases with leukopenia (28.4%),49 cases of patients leukocyte increased (51.6%),so,anemia is common;three were 30 cases with three items abnormal（31.6％）and 65 cases with one item abnormal at least (68.4%),the incidence of abnormal peripheral blood in leukocythemia patients were higher than that in patients with bone marrow infiltration,Particularly the patients with increased leukocyte or three items abnormalities were more common in leukemia; Abnormal cells in peripheral blood were observed in 66 cases (69.5%); chemotherapy efficiency reached 65.2% in the patients with bone marrow involuement,the median survival time was 11.5 months.

结果发生骨髓侵犯病例中I期4例（4.2%）， II期12例（12.6%），Ⅲ期36例（37.9%）恶性淋巴瘤分期，Ⅳ期43例(47.4%)；病理类型以小淋巴细胞性，弥漫型裂细胞性（改为：弥漫性大B细胞型淋巴瘤）和淋巴母细胞性淋巴瘤多见；纵隔淋巴结肿大、脾脏肿大和脾受侵患者易发生骨髓侵犯；骨髓侵犯患者外周血中贫血56例(58.9%)，血小板减少42例(44.2%)，白细胞减少27例(28.4%)，白细胞增高49例(51.6%)，以贫血多见；三项均异常30例(31.6%)，至少一项不正常65例(68.4%)，淋巴瘤细胞白血病患者外周血象异常发生率高于骨髓浸润患者，尤其是白细胞增高或三项均异常者更常见于白血病；66例(69.5%)外周血分类中发现异常细胞；骨髓侵犯化疗有效率65.2%，中位生存期11.5个月。

BACKGROUND: Bone marrow mesenchymal stem cells inhibit activation and proliferation of T cells in vitro and support hematopoiesis of bone marrow.

背景：骨髓间充质干细胞在体外抑制再生障碍性贫血T淋巴细胞的活化与增殖，并有支持骨髓造血作用。

Four of12patients with non-leukemia were heteroploidy,2of4were precancerous lesion.The S%of marrow cell of leukemia was significant lesser than that of control.Three acute lymphocytic leukemia were got CR,and its S%was more than that before therapy.

白血病组骨髓细胞S%明显低于对照组。3例接受治疗的急性淋巴细胞性白血病患儿达到完全缓解后，其S%明显高于治疗前，非白血病组的骨髓细胞周期与正常对照组差异无显著性。

Apoptosis of lymphocytes in bone marrow, spleen, thymus and bursa was detected by light microscope, electron microscope and terminal- deoxynucleotidyl transferase UIP nick end labeling. The results showed ALV-J could induce incoordinate apoptosis of lymphocytes in thymus, bursa and spleen, which was mainly found in early time. And the apoptosis was much more obvious in thymus than in other immune organs.

以电镜观察和HE染色、原位末端标记染色光镜观察对ALV-J感染和混合感染鸡的骨髓、脾脏、胸腺、法氏囊等免疫器官中淋巴细胞的凋亡进行了形态学研究，首次发现ALV-J可诱导胸腺、法氏囊和脾脏中不同程度的淋巴细胞凋亡，凋亡主要见于早期，ALV-J与REV混合感染时淋巴细胞凋亡尤为显著，以胸腺中最为明显。

Methods: Mitotic Index, chromosome aberration and micronucleus test in bone marrow lymphocytes of mice were determined.

采用小鼠骨髓淋巴细胞有丝分裂指数试验、染色体畸变试验、微核试验，观察蒲公英水煎液对小鼠骨髓淋巴细胞的遗传损伤效应的影响。

The sry-gene chimerism of bone marrows, spleen and thymus of the receiptor, T-lymphocyte subpopulation of peripheral blood cells, ConA and LPS induced T and B cells proliferation activity tests, Mixed lymphocyte reaction between the donor and the receiptor and the third part, the incidence rate of GVHD and survival analysis were observed in mice after 8Gy TBI with MSCs and haplo-BMT treatment together.

通过观察半相合BMT联合MSCs治疗致死剂量照射小鼠后不同时间骨髓、胸腺和脾脏中供者细胞植入，外周血中的淋巴细胞亚群，ConA和LPS刺激的T、B淋巴细胞增殖，供受者及第三者混合淋巴细胞反应，急、慢性GVHD的发生率和生存分析，提示MSCs促进骨髓干细胞植入，加快T淋巴细胞增殖，促进体液免疫恢复，通过供受者免疫耐受，减少GVHD发生率，提高半相合BMT动物生存率。

Immunorelated pancytopenia or hemocytopenia is a kind of disease with a relative clear pathological mechanism which was separated from bone marrow failure disease.It was thought to be caused by unbalance of T lymphocyte regulation and abnormal of B lymphocyte mount,subgroup,and function,which result in production of autoantibodies destroying or suppressing the inmature bone marrow hematopoietic cell and peripheral hypocytosis.

免疫相关性全血细胞减少或血细胞减少症是从骨髓衰竭性疾病中分离出的一种病理机制相对清晰的独立疾病体系，是由于T淋巴细胞调控失衡导致B淋巴细胞数量、亚群、功能异常，进而产生抗骨髓未成熟造血细胞自身抗体并破坏或抑制之，最终导致外周血细胞减少的一类疾病。

BACKGROUND: Alloimmune lung injury, characterized by perivascular lymphocytic inflammation, lymphocytic bronchiolitis, and obliterative bronchiolitis, causes substantial morbidity and mortality after lung transplantation and bone marrow transplantation, but little is known regarding its pathogenesis.

背景：同种免疫肺损伤以管周淋巴细胞浸润、淋巴细胞性细支气管炎和闭塞性细支气管炎为特征，它在肺移植和骨髓移植患者中有较高的患病率和死亡率，但是其病因学目前知之甚少。

ALA-PDT alleviated GVHD following allo-BMT and preserved GVL in ALL mice One-way mixed lymphocytes predisposed with ALA-PDT and marrow cells from the donors were infused into ALL mice. The body weight increase, haematogenesis recovery and survival time were better then all the other groups.

ALA-PDT减轻急性淋巴细胞白血病(acute lymphoblastic leukemia，ALL)小鼠同种异基因骨髓移植后GVHD反应，并且保留了GVL效应将经过ALA-PDT处理过的单向混合淋巴细胞联合供鼠的骨髓细胞输注给ALL小鼠体内，ALL受鼠的体重增长情况、造血功能恢复情况及无病生存时间等指标明显好于对照组。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。