骨髓性白血病

Four of12patients with non-leukemia were heteroploidy,2of4were precancerous lesion.The S%of marrow cell of leukemia was significant lesser than that of control.Three acute lymphocytic leukemia were got CR,and its S%was more than that before therapy.

白血病组骨髓细胞S%明显低于对照组。3例接受治疗的急性淋巴细胞性白血病患儿达到完全缓解后，其S%明显高于治疗前，非白血病组的骨髓细胞周期与正常对照组差异无显著性。

The move on the part of the agency and drug maker comes after a study appeared in Nature Medicine earlier this year reporting cardiotoxic side effects of the drug in 10 patients with chronic myelogenous leukemia.

FDA和该公司对此标签的改变，是因为自然医学期刊今年稍早的一篇报导，提到此药在10位慢性骨髓性白血病患之心脏毒性副作用的研究。

Subacut myeloid leukemia can be a defined type of leukemia. The common characteristics of subacute myeloid leukemia are as follows: the onset is insidious, and anemia and hemorrhage of skin and mucosa are the main clinical manifestations. Hepatosplenomegaly is rare. There are multilineage abnormalities in blood cell counts and increased blasts in the bone marrow with cytogenetical abnormal clone in most cases. The disease course is subacute and progressive.

1、亚急性髓性白血病是一个可以确定的白血病类型，其特征为：起病隐袭，以贫血或皮肤粘膜出血为主要症状，肝脾肿大的特征较少，血象为一系、二系或三系的异常，骨髓细胞形态学检查原早幼粒细胞异常增高，细胞遗传学检查多数有克隆性异常核型，病程中可有克隆演进，呈现亚急性而进行性的临床经过。

Methods Four patients with chronic myeloblastic leukemia and 4 with acute myeloid leukemia received allo-BMT with graft from 1 - 3 HLA-mismatched related donors.

方法4例慢性粒细胞白血病和4例急性髓性白血病患者接受人类白细胞抗原1-3个位点不相合骨髓移植，用阿糖胞苷、环磷酰胺和全身照射或马利兰进行预处理。

Analysis of patient's primary leukemia blasts revealed that those carrying the t(8;21) generating AML1/ETO, the most common acute myeloid leukemia-associated fusion protein, display low levels of a microRNA-223 (miR-223), a regulator of myelopoiesis.

对原发性白血病的胚细胞进行分析发现具有 t （8；21）能够产生 AML1/ETO 蛋白，而这种蛋白是急性髓性白血病相关融合蛋白中最常见的一种，这样的白血病胚细胞具有微小 RNA-223（ miR-223）的低表达， miR-223是骨髓细胞生成的调节因子。

Furthermore, preliminary work also performed to examine whether PI3K/AKT signal transduction pathway was activated in the process of refractory leukemia development. Materials and methods An immortalized human bone marrow stromal cell line, HS-5, was introduced to establish a bi-phase culture system for the cultivation of B-lineage precursor leukemia cells. ELISA and RT-PCR were used to investigate the expression of VEGF and its receptors in the leukemia cell lines and primary childhood leukemia cells in different treated groups. Flow cytometory method and immunofluorescent staining were employed to examine the apoptosis signals both in the VP16 treated and untreated leukemia cells. Western blot was utilized to explore the PI3K/AKT activated status in the drug induced or uninduced leukemia cells and lymphocytes from healthy donors.

材料和方法使用来源于人类骨髓基质细胞的细胞株HS-5作为滋养层细胞进行急性淋巴细胞性白血病细胞的体外培养，通过细胞生物学和免疫学方法评估培养体系并鉴定出难治性白血病细胞克隆；以ELISA和RT-PCR方法检测急性白血病细胞株和患儿白血病细胞VEGF及其受体的表达，了解不同治疗阶段VEGF及其受体的表达状况，并结合临床指标进行分析，明确VEGF及其受体在白血病发生过程中的作用；流式细胞仪和免疫荧光染色法对正常健康儿童、初发白血病患儿、复发白血病患儿及缓解后患儿进行凋亡因子检测和分析，初步阐明难治性白血病抗凋亡形成的原因；蛋白印记分析检测PI3K/AKT信号传导通路在健康儿童、初发白血病和复发白血病患儿的表达，初步了解难治性白血病形成的分子生物学机制。

In AML,monocytic leukemia is easier to become into HAL than other leukemias. In ALL,T-lineage antigens of HAL group are more easily expressed than those of NHAL group; the leukemia cells of HAL group are naiver than those of NHAL group,meanwhile the prognosis of HAL is poor. http://www.44dx.com

HAL比NHAL骨髓受抑程度更重，AML中单核细胞性白血病发生高白细胞性白血病的可能性高，ALL中HAL比NHAL更易于表达T系抗原，HAL的白血病细胞较NHAL处于更早分化阶段，同时HAL预后不佳。

It is concluded that bone marrow inhibition of hal group is more severe than that of nhal group. in aml,monocytic leukemia is easier to become into hal than other leukemias. in all,t-lineage antigens of hal group are more easily expressed than those of nhal group; the leukemia cells of hal group are naiver than those of nhal group,meanwhile the prognosis of hal is poor.

hal比nhal骨髓受抑程度更重，aml中单核细胞性白血病发生高白细胞性白血病的可能性高，all中hal比nhal更易于表达t系抗原，hal的白血病细胞较nhal处于更早分化阶段，同时hal预后不佳。

The marrow between the pink bone trabeculae seen here is nearly 100% cellular, and it consists of leukemic cells of acute lymphocytic leukemia that have virtually replaced or suppressed normal hematopoiesis .

如图可见粉红色的骨小梁之间的骨髓几乎100%是细胞，是由急性淋巴母细胞性白血病的白血病细胞构成，这些细胞实际上替代或抑制了正常的造血作用。

Other studies winnowed out abnormal DNA in lung adenocarcinoma tumors and acute myeloid leukemia.

其它研究把肺腺癌肿瘤和急性骨髓性白血病中的异常DNA挑了出来。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。