骨软骨的

Methods:9 patients including 8 male and 1 female were included in this study.2 patients suffered from both side of ANFH,5 were righe side and 2 were left side.X-ray,CT and MRI were performed before the surgery.4 hips were classified as ARCO stage 1,7 hips were stage 2.All the patients were treated as follows:the area of NFH and cystis degeneration were detected and bouche decompression was done through X-ray with C-arm,and the necrotic bone was cleared for the pathologic diagnosis under the monitoring of arthroscopy.And then the non-cell based tissue engineering bone, which was the complex of autologous red bone marrow and osteoinductice absorbing material containing BMP,was transplanted into the body.

本组9例，男性8例，女性1例；双侧股骨头坏死2例，右单侧股骨头坏死5例，左单侧股骨头坏死2例；术前均行X线摄片、CT、MRI 检查，ARCO分期：Ⅰ期4髋，Ⅱ期7髋；C型臂X线透视下行股骨头坏死区和囊性变区定位、髓芯减压，关节镜监视下，刮除坏死骨送病理；植入由自体红骨髓与含BMP的骨诱导活性材料复合成的非细胞型组织工程骨，并用空心钛钉支撑股骨头软骨下骨质。

Results Early signs of ANFH using CT showed that, in 38 femoral heads 31 cases, there were radiate star shape of high-density osteosclerosis of the trabeculae in 13 femoral head.

结果：早期ANFH的CT表现：31例38个股骨头，其中13个股骨头骨小梁呈放射状高密度的"星状征"，骨小梁境界清楚、锐利，属Ⅰ期；25个股骨头表现为骨硬化，骨小梁结构消失、模糊不清，骨密度减低及囊性改变，属Ⅱ期；并有5个股骨头在Ⅱ期影像学改变基础上出现软骨下骨折及轻微塌陷，属Ⅲ期。

Results Early signs of ANFH using CT showed that, in 38 femoral heads 31 cases, there were radiate star shape of highdensity osteosclerosis of the trabeculae in 13 femoral head.Twentyfive femoral heads showed osteosclerosis and trabeculae structure disappearing and vague,incoordinately lowostedensity area and cyst change.There were fracture under the cartilage and light subsid in 5 cases.

结果：早期ANFH的CT表现：31例38个股骨头，其中13个股骨头骨小梁呈放射状高密度的"星状征"，骨小梁境界清楚、锐利，属Ⅰ期；25个股骨头表现为骨硬化，骨小梁结构消失、模糊不清，骨密度减低及囊性改变，属Ⅱ期；并有5个股骨头在Ⅱ期影像学改变基础上出现软骨下骨折及轻微塌陷，属Ⅲ期。

Results Early signs of ANFH using CT showed that, in 38 femoral heads 31 cases, there were radiate star shape of highdensity osteosclerosis of the trabeculae in 13 femoral head.Twentyfive femoral heads showed osteosclerosis and trabeculae structure disappearing and vague,incoordinately lowostedensity area and cyst change.There were fracture under the cartilage and light subsid in 5 cases.The cases in stage Ⅰwere given decompression, while the pationtsresul in stageⅡand stageⅢ were given decompression and ostetransplant.

结果：早期ANFH的CT表现：31例38个股骨头，其中13个股骨头骨小梁呈放射状高密度的"星状征"，骨小梁境界清楚、锐利，属Ⅰ期；25个股骨头表现为骨硬化，骨小梁结构消失、模糊不清，骨密度减低及囊性改变，属Ⅱ期；并有5个股骨头在Ⅱ期影像学改变基础上出现软骨下骨折及轻微塌陷，属Ⅲ期。

objective to evaluate early signs of avascular necrosis of femoral head in adult by ct and to guide clinical treatment.methods the cases with suspicious diagnose of anfh were scaned in the both hip joints by x ray and ct to find the early signs of anfh with ct.results early signs of anfh using ct showed that, in 38 femoral heads 31 cases, there were radiate star shape of high density osteosclerosis of the trabeculae in 13 femoral head.twenty five femoral heads showed osteosclerosis and trabeculae structure disappearing and vague,incoordinately low ostedensity area and cyst change.there were fracture under the cartilage and light subsid in 5 cases.the cases in stage ⅰwere given decompression, while the pationtsresul in stageⅱand stageⅲ were given decompression and ostetransplant.conclusion ct results show that the sign of the high osteodensity and low osteodensity and cyst change can disply early anfh.

摘 要］目的：探讨成人股骨头缺血性坏死的早期ct征象并指导临床治疗。方法：对临床疑诊anfh的全部病例均行x线平片及ct检查，分析anfh的早期ct征象。结果：早期anfh的ct表现：31例38个股骨头，其中13个股骨头骨小梁呈放射状高密度的"星状征"，骨小梁境界清楚、锐利，属ⅰ期；25个股骨头表现为骨硬化，骨小梁结构消失、模糊不清，骨密度减低及囊性改变，属ⅱ期；并有5个股骨头在ⅱ期影像学改变基础上出现软骨下骨折及轻微塌陷，属ⅲ期。治疗结果：ⅰ期行钻孔髓内减压术，ⅱ、ⅲ期行钻孔减压植骨术。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

Fig 1 At the experimental side, two weeks after operation (HE ×100) Many pieces of cartilage cells and spindle-shaped mesenchymal cells were found, by light microscope Fig 2 At the experimental side, twelve weeks after operation (HE ×100) Medullary cavity had formed, which contained hemoblasts and adipocytes, but the trabculae was not typical, by light microscope Fig 3 At the experimental side, twenty-four weeks after operation (HE ×100) The typical cancellous bone had formed, by light microscope Fig 4 At the control side, twenty-four weeks after operation (HE ×100) A large part of CXB was degraded, resorbed and replaced by fibrous tissue, but there was'not any new formed bone, by light mocroscope

图1 实验侧术后2周(HE ×100)镜下可见很多软骨细胞条索和团块生成及大量梭形间充质细胞图2 实验侧术后12周(HE ×100)镜下可见有髓腔形成，内含有造血和脂肪细胞，骨小梁尚不典型图3 实验侧术后24周(HE ×100)镜下可见形成典型的松质骨结构图4 对照侧术后24周(HE ×100)镜下可见大部分CXB被降解吸收，为纤维组织替代，无新骨形成

Construct PLXRN-IL-1Ra and PLXRN-IL-10 vector, lapine synoviocytes were first transduced in culture by retroviral infection. The genetically modified synovial cells were then transplanted by intra-articular injection into the knee joints, assay of joint lavages confirmed that the gene expression was not lost after 14 days of transfer. Knees receiving the hIL-1Ra had significantly reduced cartilage breakdown. Delivery of the hIL-10 was less effective, When both genes were used together, there was a greater inhibition of cartilage breakdown and a considerable reduction of cartilage matrix degradation.

构建PLXRN-IL-1Ra、PLXRN-IL-10逆转录病毒载体，体外感染同种异体原代滑膜细胞，接着将转染了外源基因的滑膜细胞行关节腔注射入创伤性骨关节炎兔膝关节，通过对关节滑液的ELISA分析证明外源基因的表达在基因转移后14天还很稳定，只接受hIL-1Ra基因治疗的膝关节软骨损坏明显减轻，接受hIL-10基因治疗的膝关节治疗也有一定效果，当两种基因同时导入时，有非常明显的抑制软骨破坏和软骨基质降解的作用。

objective to evaluate early signs of avascular necrosis of femoral head in adult by ct and to guide clinical treatment.methods the cases with suspicious diagnose of anfh were scaned in the both hip joints by x ray and ct to find the early signs of anfh with ct.results early signs of anfh using ct showed that, in 38 femoral heads 31 cases, there were radiate star shape of high density osteosclerosis of the trabeculae in 13 femoral head.twenty five femoral heads showed osteosclerosis and trabeculae structure disappearing and vague,incoordinately low ostedensity area and cyst change.there were fracture under the cartilage and light subsid in 5 cases.the cases in stage ⅰwere given decompression, while the pationtsresul in stageⅱand stageⅲ were given decompression and ostetransplant.conclusion ct results show that the sign of the high osteodensity and low osteodensity and cyst change can disply early anfh.

摘 要］目的：探讨成人股骨头缺血性坏死的早期ct征象并指导临床治疗。方法：对临床疑诊anfh的全部病例均行x线平片及ct检查，分析anfh的早期ct征象。结果：早期anfh的ct表现：31例38个股骨头，其中13个股骨头骨小梁呈放射状高密度的&星状征&，骨小梁境界清楚、锐利，属ⅰ期；25个股骨头表现为骨硬化，骨小梁结构消失、模糊不清，骨密度减低及囊性改变，属ⅱ期；并有5个股骨头在ⅱ期影像学改变基础上出现软骨下骨折及轻微塌陷，属ⅲ期。治疗结果：ⅰ期行钻孔髓内减压术，ⅱ、ⅲ期行钻孔减压植骨术。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。