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Our findings demonstrate that in conjunction with clinical and radiographic findings, immunohistochemical evaluation with a panel of D2-40, EMA, brachyury, and GFAP is most useful in distinguishing chordoid meningioma from chordoid glioma, skeletal myxoid chondrosarcoma, extraskeletal myxoid chondrosarcoma, chordoma, low-grade chondrosarcoma, and enchondroma. A lack of strong, diffuse S100 reactivity may also be useful in excluding chordoid meningioma.

我们的结果表明,结合临床和影像学资料,D2-40、EMA、brachyury和GFAP这样一个免疫标记组合就能很好地鉴别脊索样脑膜瘤和脊索样胶质瘤、骨的黏液样软骨肉瘤、骨外的黏液样软骨肉瘤、脊索瘤、低级别软骨肉瘤、内生性软骨瘤。S100染色不强烈、不弥漫也有助于排除脊索样脑膜瘤的诊断。

Material and MethodsRA Rabbit Model group: 15 early RA rabbits of the same weight and variety Control group:10 normal rabbits of the same weight and varietyMethods of making RA rabbit model:elect 15 normal rabbits of the same weight and variety, dissolve Ovalbumin in 0.9% sodium chloride solution, to make the solution of 20mg/ml concengtration, blend the same quantity of complete Freund′s Adjuvant equably ,inject the mixed solution into endermic tissue of the rabbit′s scapular section, making the rabbits allergic, inject 1 ml of the mixed solution to one rabbit every time, inject 1 ml of the mixed solution in 5 different places of the rabbit′s scapular section, inject the rabbit one time every week,inject 3 weeks continuously,it turned out to be that the rabbits will be allergic, inject Ovalbumin blent with the 0.9% sodium chloride solution into the knee joint cavity of the rabbits in the fourth week, 5 mg Ovalbumin every knee joint cavity,two knees of every rabbit of the 15 rabbits are both injected,the arthrosis diameter and the exterior temperature of the knees will be added obviously in 24 hours,and they will drop gradually,at the time of the 14th or 21th day, the arthrosis diameter and the exterior temperature of the knees will get to the balance time,the incidence rate of RA is 100%.after the RA model succeeds,it is the early time of RA from the first week to the fourth week,after the fourth week,it is the late time of RA, the cartilage of the femoral condyle and the subchondral bone cortices will be changed unrecoverily.

资料与方法RA模型组:早期RA家兔模型15只,品种及体重接近。对照组:正常家兔10只,品种及体重接近。RA家兔模型制作方法:选取15只成年家兔,体重、品种接近,将卵蛋白溶解于生理盐水,配成浓度为20mg/ml的溶液,与等量完全弗氏佐剂混匀,注入家兔肩胛区皮下致敏,每只家兔每次注射1ml,于肩胛区5个不同区域注射,每周一次,连续注射3周而致敏,第4周向膝关节腔注射卵蛋白生理盐水溶液,每只关节腔注射5mg卵蛋白,15只家兔膝关节全部注射,24h内此关节直径和表面温度大幅度上升,以后缓慢下降,至14~21d达到平台期,发病率达100%。造模成功后第1~4周为早期改变,第4周以后出现不可逆的关节软骨及骨破坏。采用高频超声对RA模型组与对照组的膝关节髌上囊液体厚度、滑膜及股骨髁软骨厚度及软骨下骨皮质的回声情况进行对比观察。结果RA组模型组膝关节髌上囊积液及滑膜的厚度明显厚于对照组,其股骨髁软骨的厚度与对照组相比无明显差异,其软骨下骨皮质与对照组相比无明显改变。

Cartilage damage can also occur as part of other rare conditions such as osteochondritis dissecans (where loss of blood supply causes a piece of bone and cartilage to separate from the bone) and relapsing polychondritis (which causes swelling of the cartilage in the ear).

软骨损伤,也可能会出现的一部分,其他罕见的条件,如剥脱性骨软骨炎(其中损失的血液供应的原因一块骨与软骨脱离骨)和复发性多软骨炎(造成肿胀,关节软骨在耳)。

Then the cultivated chondrocytes were embedded in fibrin glue fused on spongy bone, covered with priosteal flap; the complex was used to repair the femoral trochlea osteochondral defect which size is 3mm × 4mm × 4mm made in rabbit knee joint.

在A组的每只兔子的一侧膝关节股骨滑车部人为造成3mm×4mm的骨软骨缺损,骨刀切除软骨下骨到髓腔渗血为止(厚约4mm),压迫后FG止血;取髂骨骨块,并尽可能保留松质骨,取下的骨块用PBS反复清洗,以除去血细胞,将松质骨填充在骨缺损处,松质骨面朝向关节腔,高度与周边软骨下骨齐平,把骨膜片生发层朝向关节腔,用无创伤缝合线缝合在周边的软骨或滑膜组织上;向EP管中加入1/2悬液体积的FG主体胶溶液并混匀,再与主体胶等体积的催化剂溶液一同注射入骨膜与骨块密闭的腔隙中;同理处理另一侧膝关节。B组处理与A组相比只是不加入软骨细胞;C组造成骨软骨缺损,FG覆盖创面后单纯用骨膜修复缺损。

Methods: Nineteen patients with symptomatic chondral and osteochondral lesions of the knee who were treated with fresh osteochondral allografts between 1999 and 2002 were prospectively followed. The mean age at the time of surgery was thirty-four years.

从1999到2002年随访了19位接受新鲜骨软骨同种异体骨治疗有症状的膝关节软骨和骨软骨病变的病人,手术时的平均年龄为34岁。

Methods: Nineteen patients with symptomatic chondral and osteochondral lesions of the knee who were treated with fresh osteochondral allografts between 1999 and 2002 were prospectiely followed. The mean age at the time of surgery was thirty-four years.

从1999到2002年随访了19位接受新鲜骨软骨同种异体骨治疗有症状的膝关节软骨和骨软骨病变的病人,手术时的平均年龄为34岁。

BACKGROUND: Many studies have achieved certain progress in repair of the osteochondral defect by tissue-engineered chondral composite graft which was constructed with different methods. But the existing problems of these methods are presented that the coupling of interfaces of bone and cartilage in graft and host is not ideal.

背景:国内外许多研究通过不同的构建方法构建组织工程化软骨支架复合体修复骨软骨联合缺损,且取得了一定的进展,但目前各种方法存在的问题突出表现为组织工程化的软骨和骨组织之间的界面、移植体和宿主骨和软骨之间的界面耦合不够理想。

There hae been a few reported cases of bursal osteochondromatosis inoling the retrocalcaneal, subacromial, and subcoracoid bursae2,10,11; howeer, infrapatellar bursal osteochondromatosis has neer been reported in the English-language literature, to our knowledge.

已报道的粘液囊骨软骨瘤病病例包括跟骨后、肩峰下及喙突下粘液囊的骨软骨瘤病;然而,据我们所知,髌骨下粘液囊骨软骨瘤病的报道却从未在英文文献中见到过。

Osteochondromas, or osteocartilaginous exostoses, are the most common primary benign bone tumors and usually occur in the metaphyses of long bones.

骨软骨瘤,或称骨软骨外生骨疣,是最常见的原发性良性骨肿瘤,通常发生于长骨的干骺端。

It is further confirmed by the experiment of muti-inducement that MSMPs can differentiate into osteocyte sand fibrocartilage cytes and it is osteo-chondro progenitor cells with the potential ability to evolve muti-differentiated. This added evidence to the view that condylar cartilage differentiated from osteo-chondro progenitor cells in the mesenchymal cells of mancibular periosteal.

体外分离培养鼠胚下颌体骨膜间质细胞并研究其生物学特性,通过多向诱导实验进一步证实:下颌骨膜间质细胞可能为骨—软骨的前体细胞,可分化为成骨细胞及纤维软骨细胞,具有多向分化潜能,此结果进一步支持髁突软骨是由下颌骨膜间质中骨—软骨前体细胞发育而来。

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然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

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