骨肿瘤

Methods 21 cases of craniopharyngoima in suprasellar region were resected by trans-supraorbital approach, the diameter of tumors varied from 3.0 to 6.5cm; partial cystic tumor in 13 and solid tumor in 8. Skin incision was made in eyebrow, the hemicycle bone flap was approximately 2.5cm×3.0cm, tumor was dissected in I,II,III spaces and trans-endplate.

对21例位于鞍上，肿瘤上下径为3.0～6.5cm的颅咽管瘤患者(部分囊性变者13例，完全实性者8例)，作眉弓内弧形小切口，在眶上铣开一为2.5cm×3cm的半圆形小骨瓣，术中根据肿瘤位置，从I、II、III间隙和终板入路切除肿瘤。

Objective: The purpose of this study was to investigate the effect of TNF-α on osteoclast differentiation in primary murine bone marrow cell culture with and without RANKL.

目的：在诱导破骨细胞分化的体外骨髓细胞培养系统中，研究破骨细胞分化因子存在和不存在的情况下，肿瘤坏死因子α对破骨细胞分化的影响。

In conclusion ,the results of this study showed that the inducing agent HMBA could effectively inhibit the proliferation activity of the human ostosarcoma MG-63 cells,cause the arrest of G0/G1 phase, reverse the malignant phenotype characters,upregulate expression of the osteoblat-like phenotype markers including collagen,osteocalcin,osteonectin , facilitated the formation of bone nodule .

本研究的结果表明HMBA能够有效抑制人成骨肉瘤MG-63细胞增殖活动，改变肿瘤增殖核抗原表达，将细胞周期阻滞在G0/G1期，逆转人成骨肉瘤细胞恶性表型特征，在促进终末分化标志物Ⅰ型胶原纤维蛋白、骨钙蛋白、骨粘素的表达同时，促进骨结节生成，从而说明HMBA能够诱导人成骨肉瘤MG-63细胞终末分化，并且Rg1、BPO-L、Rg1+BPO-L以及Rg1+HMBA等均具有终末诱导分化能力。

Type Ⅲ was with invasion total joint surface and as integmentale,all tumor segment including joint could be cut,but the shape of cut close to the diaphysis was echelonment.

型病例肿瘤侵蚀整关节面和骨皮质，可切除包括关节在内的整个瘤段骨，只是近骨干侧截骨呈阶梯状。

Type Ⅲ was with invasion total joint surface and as integmentale,all tumor segment including joint could be cut,but the shape of cut close to the diaphysis was echelonment.

型病例肿瘤侵蚀整个关节面和骨皮质，可切除包括关节在内的整个瘤段骨，只是近骨干侧截骨呈阶梯状。

All tumors were histologically high grade (6 grade III and 10 grade IV). Three tumors showed heterologous elements, 2 osseous, and 1 rhabdomyoblastic. More often scattered than diffuse, S-100 protein staining was noted in 11 of 16 tumors and variable collagen IV staining in 10 of the 16. Immunoreactivity for p53 protein was diffuse and strong in 7 of 11 tumors. Twelve patients died within 17 months to 3 years of diagnosis, 1 was lost to follow-up, 2 are very recent cases, and 2 patients are currently alive, 1 after 2 recurrences, and another with spinal leptomeningeal metastases.

所有病例在组织学上都是高级别（6例III级和10例IV级）。3例肿瘤含有其他成分：2例含骨和1例含 rhabdomyoblastic.S-100蛋白染色显色于16例肿瘤中的11例，IV型胶原染色显色于16例中的10例，这些染色通常分散而不弥散。11例肿瘤中7例的p53蛋白免疫反应弥散且强烈。12例病人死于确诊后的17个月至3年，1例随访失败，2例是最近的病例，还有2例现在还活着，其中1例复发，另1例发生脊髓脑膜转移。

Focus on research work and clinical studies in musculoskeletal oncology, especially about mechanism and biological therapy of osteosarcoma, such as proteomics studies of osteosarcoma, prospective control study of osteosarcoma, registration system of musculoskeletal oncology and genic tests about the familial inheritance osteoenchondroma, etc.

拟开展《骨肉瘤特异性相关抗原的蛋白质组学研究》、《骨肉瘤多中心前瞻性随机对照研究》、《骨与软组织肿瘤注册-会诊-随访登记系统》、《多发性骨软骨瘤家族遗传性基因的检测》等课题的相关研究工作，承担国家、省级和市级重大项目等课题的申报。

Local defects in bone as a result of trauma, neoplasm, infection, or congenital diseases are usually filled in and repaired with autografts The fresh autografts are considered to have the highest osteogenous capacity and no immune reaction.

外伤，肿瘤或感染施行骨切除或某些先天性疾病等原因引起的骨缺损常用自体骨填补，修复，其主要原因是自体新鲜骨成骨能力好，无免疫排斥反应。

Abstract］ objective to discuss radiological findings of parosteal osteosarcoma on emphasis combined with clinical pathology and literature.methods 4 cases of parosteal osteosarcoma proved by operation and pathology were analyzed retrospectively.results female was 3 cases,male was 1 case,average age was 30.5 years old,these tumors were arised on posterior border of distal femur and popliteal cavity,presented as lobular dense ossified mass,defined lesion.one case had villose margin.a thin narrow lucent zone separated the mass from the cortex at two cases.one case underwent angiography,there was no malignant feature.conclusion parosteal osteosarcoma may be divided into low-grade type and high-grade type.radiological manifestations of early stage possess character,early diagnosis conduces to establish rational treating plan and evaluate prognosis.

目的 结合临床病理学特征和文献资料，重点讨论皮质旁骨肉瘤的x线特征。方法收集经手术、病理证实的皮质旁骨肉瘤病例4例，对其进行回顾性分析。结果 4例患者女3例，男1例，平均年龄30.5岁，肿瘤均发生于股骨远端后侧和腘窝处，表现为分叶状致密骨化肿块，边界清晰，其中1例边缘呈绒毛状改变，2例有细窄透亮带与骨皮质相隔，1例行血管造影，未见血管池等恶性征象。结论皮质旁骨肉瘤分为低度恶性和高度恶性两种，早期影像学表现有特征性，早期诊断有助于制订相应的治疗方案和评估预后。

SBAP and sALP were significantly correlated with the number of metastatic loci in bone.Conclusion Significant correlation was observed between uPYD and uDPD,sBAP and sALP in advanced cancer patients with bone metastases.

骨转移时uPYD和uDPD、sBAP和sALP之间显著相关，uPYD、uDPD、sBAP水平和骨痛明显相关，uDPD、sBAP水平和肿瘤骨转移程度、骨转移数目明显相关。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。