骨肿瘤

9The sieve that scanning of 9mTc-MDP nuclide bone can check in installment as lung cancer checks the method; progress as lung cancer course of diseases, tumor labels the level of content CEA, CA125, NSE and CYFRA21-1 rises gradually. Other people of number of tumour of combination of 99mTc-MDP bone scanning has fundamental value in be not cellule lung cancer to be diagnosed in installment.

99mTc-MDP核素骨扫描可作为肺癌分期检查的筛查手段；随着肺癌病程的进展，肿瘤标记物CEA、CA125、NSE和CYFRA21-1的水平逐渐上升。99mTc-MDP骨扫描联合肿瘤标记物在非小细胞肺癌分期诊断中具有重要的价值。

There were 36 males and 40 females,with the average age of 47.7 years.36 patients presented with sciatica and perineal numbness,11 patients had painless mass and the other 20 were identified due to other causes.Among 67 benign neurogenic tumors,54 were originated from S1-S3 nerves,3 from S4-S5 nerves and 11 from the presacral space without caudal involvement.Giant cell tumor was found in 60 patients,which included 24 males and 36 females,with an average age of 32 years.Upper sacrum（S1-S2） was involved firstly.There were 56 patients（average,37.7 years） diagnosed as other primary benign bone tumors,which included 24 cases of teratomas,epidermoid cyst or dermoid cyst.Other malignant tumors,including chondrosarcoma （17）,Ewing′s sarcoma/PNET（14）,multiple myeloma（12）,lymphoma（6） and osteosarcoma（6） were found in 64 patients.

其中脊索瘤95例，男62例，女33例，平均年龄55.7岁，骶尾区疼痛是主要症状（82例），半数以上患者伴有坐骨神经痛，肿瘤多先累及低位骶骨（S3~S5）；神经源性肿瘤76例，男36例，女40例，平均年龄47.7岁，神经纤维瘤43例，神经鞘瘤24例，恶性神经鞘瘤9例，主诉多为坐骨神经痛、会阴部麻木（36例）和无痛性包块（11例），20例患者为查体或其他原因检查时发现，67例骶骨良性神经源性肿瘤起源于S3以上神经者54例，起源于S3以下神经者3例，发生于骶前未累及骶管者10例；骨巨细胞瘤60例，男24例，女36例，平均年龄32岁，腰骶尾部不适（37例）、坐骨神经痛（21例）是主要的临床表现，肿瘤多先累及上位骶骨（S1~S2）；骶骨其他原发良性肿瘤及瘤样病变56例，包括畸胎瘤、皮样囊肿、表皮样囊肿共24例；其他原发恶性肿瘤64例，包括软骨肉瘤17例，尤文肉瘤14例，多发性骨髓瘤12例，成骨肉瘤6例等。

Genesis,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.

骨巨细胞瘤血管生成是近年来研究热点，实体瘤的发生、发展及转移与肿瘤的血管生成密切相关；细胞外基质降解在肿瘤的浸润和转移中起到关键作用；肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。

Soft tissue was repaired and extremity function was reconstructed by adopting allogeneic bone graft and replanting devitalized bone. Extremity functions, bone healing conditions, and complication were estimated according to Mankin metheds.

采用同种异体骨移植和自体瘤段骨灭活再植修复肿瘤切除后骨缺损的同时行软组织修复和功能重建，按Mankin分级法评价保肢术后功能恢复情况，骨愈合情况及并发症等。

1Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China; 2Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084, China

北京大学人民医院骨与软组织肿瘤治疗中心，清华大学精密仪器与机械学系，北京大学人民医院骨与软组织肿瘤治疗中心，清华大学精密仪器与机械学系

There were 22 malignant tumors including 11 osteosarcomas, 5 chondrosarcomas, 2 malignant fibrous histocytomas, and one each of malignant osteoblastoma, alveolar sarcoma, rhabdomyosarcoma, malignant giant cell tumor of bone. 28 benign tumors included 27 giant cell tumors of bone and 1 benign fibrous histocytoma.

肿瘤类型：恶性肿瘤22例，其中骨肉瘤11例，软骨肉瘤5例，恶性纤维组织细胞瘤2例，恶性骨母细胞瘤、腺泡状肉瘤、横纹肌肉瘤、骨巨细胞肉瘤各1例；良性肿瘤28例，其中骨巨细胞瘤27例，良性纤维组织细胞瘤1例。

These interactions result in enhanced growth of tumorcells and osteolysis that is followed by an osteoblastic response.

肿瘤细胞转移到骨骼，与骨微环境相互作用，结果既促进肿瘤细胞的生长，同时又诱导溶骨现象以及随后出现的成骨性损伤。

Its mechanism has not been made clear , we now have no effective method to synteresis and therapy. However, as generally acknowledged, the growth and metastasis of tumor have close cooperation with Vascularization and tumor extracellular matrix.

乳腺癌骨转移的机理目前尚未弄清，医学发展至今尚没有一种较有效的方法来预防及治疗骨转移，但肿瘤的生长及转移与血管生成及肿瘤细胞外基质密切相关的理论已逐渐得到公认。

Conventional imaging technique which unsubtracted bone was used first,use 3D treatment on workstation to reconstruct cerebral vessels,to diagnose aneurysm,vascular malformation and tumor as well as to evaluate the preoperative and postoperative efficacy.Subtract bone techniques including one by one slice subtraction,semi-automatic digital subtraction radiography,matched mask bone elimination and control tube exposure light spot imaging technique can show the vessels more clear without the interference of bone as well as the relationship between vessel and pathological changes more accuracy.

首先是未去骨的常规成像技术，利用工作站进行多平面重建技术、最大密度投影、容积再现、表面遮盖法等多种三维处理得到头部血管及肿瘤图像，对动脉瘤、血管畸形及肿瘤血管进行病变诊断及术前、术后评价；其次是近年出现的逐层减影、半自动数字减影、匹配蒙片骨去除法及控制球管曝光点的减影等去除颅骨的减影技术，没有颅骨的干扰血管显示更加清楚，血管与病变关系显示更准确。

Methods 59 patients with bone metastasis and pain were divided groups according to age,degree of bone metastasis and histology of tumors.59 patients all received at least 1 to 4 times treatment of 153Sm-EDTMP(0.5～1.0mci/kg)by mainlined and SPECT bone scan were repeated 2 days after injection.

对我院近两年使用153Sm-EDTMP行内照射治疗的59例肿瘤转移性骨痛病人进行回顾性分析，按年龄、病灶数量、不同肿瘤分组，单次剂量给予153Sm-EDTMP18.5～37MBq/kg静脉注射，第2天行全身骨显像观查放射分布情况，建立随访。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。