骨碎补

Aim To further study the chemical constituents from the marcroporous adsorption resin 50% EtOH eluent of Drynaria fortunei.

目的 研究骨碎补大孔吸附树脂柱色谱以体积分数50%乙醇洗脱部分的化学成分。

The results of empirical study to illustrate that the flavone of rhizome drynaria has considerable significance to improve the bone formation action of SOP.

实验研究结果说明，骨碎补总黄酮对增强老年性骨质疏松症成骨作用具有重要的意义。

Part I. Isolation of Drynaria fortunei J. SMITH Components The rhizoma of Drynaria fortunei J.

中文摘要第一部分：骨碎补的成分分离槲蕨（Drynaria fortuneiJ。

To illustrate the flavone of rhizome drynaria can extently amend the lumbodosal pain and lumbodynia with SOP, the pain obviously released after 3 months.

说明骨碎补总黄酮在一定程度上能够改善老年性骨质疏松症引起的腰背痛及腰痛，缓解疼痛的幅度以治疗的前3个月最为明显。

Senile Osteoporosis;flavone of rhizome drynaria;osteogenesis;clinical study;experimental study

老年性骨质疏松症；骨碎补总黄酮；成骨作用；实验研究；临床研究

the drynaria has the effect of estrogen,it can prevent and cure post-menopausal through stimulating the growth of osteoblast and improving the building of bone quantity.

骨碎补具有类雌激素样作用，能够刺激成骨细胞生长，促进骨量生成，从而起到防治绝经后骨质疏松症的作用。

Methods The constituents in the 60% ethanol extract of Drynaria fortunei were isolated by a combination of silica gel, Sephadex LH-20 and ODS chromatographies and their structures were identified by spectral methods.

采用硅胶、Sephadex LH-20、ODS柱色谱分离骨碎补根茎的活性成分，应用理化方法及1D-NMR、2D-NMR方法确定化学结构，并检测对UMR 106细胞增殖的影响。

From the theoretical angle, to analyze and summarize the morbility reason of Senile Osteoporosis, to approach the effect of the flavone of rhizome drynaria on the lipidision of marrow stroma cell, as well as the senescence and apoptosis of osteoblast through the experimental study; from the clinical angle, to observe the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, to supply scientific theory basis for clinical application.

从理论角度分析总结老年性骨质疏松症的发病原因，并通过实验研究探讨骨碎补总黄酮对骨髓基质细胞脂质化的影响，以及对成骨细胞衰变和凋亡的影响，从临床角度观察其治疗老年性骨质疏松症的效果，为临床应用提供科学理论依据。

The traditional Chinese medicine: Gusuibu Drynaria fortunei J.

中文摘要骨碎补为水龙骨科槲蕨（Drynaria fortunei J。

And the level of E2 in the ethanol pharmaceutical preparation of drynaria group group was higher than the water pharmaceutical preparation of drynaria group.the levels of BGP in the normal group, water pharmaceutical preparation of drynaria group,ethanol pharmaceutical preparation of drynaria group were obviously increased as compared with the normal group P.

与正常组比较，模型组和骨碎补水提、醇提组BGP显著升高(P 。05)；尼尔雌醇治疗组与模型组比较显著降低(P 。01)。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。