骨碎补

Objective To study the therapeutic effects of Chinese herbs Drynaria, Cynomorium, Epimedium and Chain Fern on osteoporotic ovariectomized rat models.

目的 比较骨碎补、锁阳、淫羊藿和狗脊4种补肾中药对去卵巢大鼠骨质疏松的作用。

It is hard and tough in texture and difficult to comminute so that active constituents is uneasy to be extracted, thus prosessed products are often used.

因此，本课题对骨碎补炮制工艺及质量标准进行了研究，为临床用药更合理、更有效提供科学的理论依据。

Appraised the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, according to the dynamic observation on integrative scores of lumbodorsal pain and lumbodynia,"VAS section grading method" on lumbodynia,"Barthel index rating method" on ADL, detected BMD on anterior-posterior position lumbar2~4 vertebra body and proximate of femur including neck/ward/troch, and determined the index of bone transition including BGP/PINP/ICTP through the radioimmunity method before and after treated half a year, then contrast intragroup and selfgroup. Depending on the standard of curative effect, contrast the difference of curative effect between two groups.

采用随机对照的方法，分为治疗组36例，对照组34例，依据对腰背痛及腰痛综合评分进行动态观察；依据"疼痛VAS线段分级法"对腰背痛（静止痛、翻身痛、久坐痛、起身痛、弯腰痛、步行痛、睡眠痛、叩击痛、压痛）进行量化动态观察；依据"Barthel指数评定法"对老年性骨质疏松症日常生活活动能力进行观察；采用双能X线骨密度仪对腰椎(L2-L4)、股骨近端各部位：股骨颈、股骨三角区、股骨粗隆进行骨密度定量检测；应用放射免疫法对骨转换指标进行测定，骨形成指标：骨钙素、Ⅰ型前胶原氨基端前肽；骨吸收指标：Ⅰ型胶原交联羧基末端肽等，评价骨碎补总黄酮治疗老年性骨质疏松症的临床效果。

Drynaria showed markedly improving effect on the bone and uterine morphological construction of rats.

组织形态学观察可见骨碎补能明显改善病理状态下大鼠骨、子宫的形态结构。

To illustrate that the flavone of rhizome drynaria can improve proximate of femur bone strength, and prevent fracture of hip.

说明骨碎补总黄酮对老年性骨质疏松症具有提高整体骨量的作用，同时能够提高股骨近端骨强度，预防髋部骨折。

Speranskia tuberculata, Drynaria, psoralen shamisen, traditional Chinese medicine effective against pain, but also enhance the anti-inflammatory drugs and radiation treatment on the analgesic effect of bone metastasis.

透骨草、骨碎补、补骨脂三味中药对骨痛有效，也可加强解热镇痛药及放射治疗对骨转移癌的止痛效果。

Primary culture of osteoclasts cells were isolated from newborn Wistar rats. The effects of Drynaria fortunei on bone cell viability were determined by the method of MTT assay. The effects on osteoclasts cells activities were analyzed by acid phosphatase and lactate dehydrogenase.

本实验用Wistar新生老鼠做细胞初代培养，以体外试验模式探讨骨碎补对蚀骨细胞的影响，经由不同时间点的细胞存活率测试，分析酸性磷酸酵素和乳酸去氢酵素的含量来测量酵素活性。

Clinical study indicated: the flavone of rhizome drynaria can promote collagen synthesis, improve bone transition, increase bone formation, delay bone resorption, furthermore, improve SOP patients' integer bone mass and proximate of femur bone strength, and prevent fracture of hip.Eventually, the level of living independence amended and the quality of life improved overall.

临床研究表明：骨碎补总黄酮具有促进老年性骨质疏松症骨胶原的合成，提高骨转换，增加骨形成，减缓骨吸收状况等作用，进而提高老年性骨质疏松的整体骨量，缓解腰背痛，提高股骨近端骨强度，预防髋部骨折，提升独立性生活水准，全面提高老年性骨质疏松症患者的生命质量。

Appraised the clinical effect of the flavone of rhizome drynania on Senile Osteoporosis, according to the dynamic observation on integrative scores of lumbodorsal pain and lumbodynia,"VAS section grading method" on lumbodynia,"Barthel index rating method" on ADL, detected BMD on anterior-posterior position lumbar2~4 vertebra body and proximate of femur including neck/ward/troch, and determined the index of bone transition including BGP/PINP/ICTP through the radioimmunity method before and after treated half a year, then contrast intragroup and selfgroup. Depending on the standard of curative effect, contrast the difference of curative effect between two groups.

采用随机对照的方法，分为治疗组36例，对照组34例，依据对腰背痛及腰痛综合评分进行动态观察；依据&疼痛VAS线段分级法&对腰背痛（静止痛、翻身痛、久坐痛、起身痛、弯腰痛、步行痛、睡眠痛、叩击痛、压痛）进行量化动态观察；依据&Barthel指数评定法&对老年性骨质疏松症日常生活活动能力进行观察；采用双能X线骨密度仪对腰椎(L2-L4)、股骨近端各部位：股骨颈、股骨三角区、股骨粗隆进行骨密度定量检测；应用放射免疫法对骨转换指标进行测定，骨形成指标：骨钙素、Ⅰ型前胶原氨基端前肽；骨吸收指标：Ⅰ型胶原交联羧基末端肽等，评价骨碎补总黄酮治疗老年性骨质疏松症的临床效果。

Chicken soup recipe can be accompanied by mother, pig soup, lamb soup, Lu Jin soup, stew live fish, etc., can be appropriate to drink drinkers Eucommia Drynaria wine, Millettia wine, papaya tiger bone wine.

骨折的人吃什么容易好得快啊？食谱可配以老母鸡汤、猪骨汤、羊骨汤、鹿筋汤、炖水鱼等，能饮酒者可适当饮用杜仲骨碎补酒、鸡血藤酒、虎骨木瓜酒等。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。