骨架

In this dissertation, we have prepared 15 new MOFs by using different organic carboxylate ligands, and analyzed their topology structures as well as explored their multifunctional properties.

本论文依据晶体工程学原理，从金属有机骨架晶体材料的功能性出发，主要研究这类化合物的合成、拓扑结构和多功能性质，旨在探索金属有机骨架晶体材料的结构多样性；并在结构研究的基础上，开发新型次级结构单元以及具有新颖拓扑结构的金属有机骨架晶体材料的设计合成与性质应用。

The influences of the inclusion of Na~+ into each conformer (C7AB, C7"AB, C7eqB, C5A, C7axB orα"B) of AD molecule on the Ramachandran angles of molecular backbone and the hydrogen bonds in AD moiety were discussed in detail. It was found that in the forming process of bidentate structures of Na~+-AD ion-complexes, the original H-bonds in AD molecule were fully broken down, accompanying with the new formation of the two Na-O bonds.

论文中详细探讨了Na~+-AD络合离子六种构象的空间构型，分析了丙氨酸二肽与Na~+作用过程中AD分子骨架Ramachandran角及分子内N(1)–H(1)…O(2)、N(2)–H(2)…O(1)、N(1)–H(1)…N(2)和N(2)–H(2)…N(1)氢键的变化，研究发现Na~+与AD分子形成双齿结构时，AD骨架中原先的氢键全部被破坏，继而形成了两个新的Na-O键；Na~+与AD分子形成单齿络合离子时，AD骨架中原先的氢键或者得到增强或者断裂之后出现新的强度更大的氢键。

Truncation mutations in the adenomatous polyposis coli protein are responsible for familial and sporadic colonic tumours. Except for its function as a role in regulating b-catenin, recent studies show that APC has additional roles in cytoskeletal regulation. It binds to microactin and microtubules directly and indirectly. Furthermore, APC plays an important role in mediating the detraction of chromosome.

编码APC蛋白(adenomatous polyposis coli， APC)基因的缺失突变会导致家族性和散发性的结肠癌，APC蛋白除了能直接参与Wnt信号途径调节b-catenin的浓度之外，最近的研究表明APC蛋白能够与细胞骨架的主要成分微管和微丝直接或间接结合，通过调节微管的解聚和聚合，间接调节染色体的分离，作为潜在的细胞骨架调节分子将细胞骨架与重要的细胞信号转导通路紧密联系在一起。

Basic Study on Erection Planning Method for Beam String Structure 2,Study on Structural Characteristic of Hybrid Skeleton with Tension Strings 3, Proposal of Reversed Progress Teclmique for Tension Structures and Its Application 4,Mechanical Behavior of Hybrid Skeleton with Tension String during Construction 5,Experimental Studies on Structurel Characteristic of Hybrid Skeleton with Tension Strings 6,Mechanical analysis of a type hybrid spatiaI structure composed of cables,bars and beams 7, Tensile force compensation analysis method and application in construction for hybrid structures 8,Tensile forces emulationaI analysis of prestressed cables for multistage tension construction method 9,Reverse analysis method of construction centrel tensile force for prestressed space structures

1 ，基础研究规划方法架设张弦梁结构 2 ，结构特征研究混合骨架张力弦 3 ，建议反进展Teclmique张力结构及其应用 4 ，力学性能的混合骨架张力字符串施工 5 ，实验研究Structurel特征混合骨架张力弦 6 ，机械分析型杂交spatiaI结构组成的电缆，酒吧和梁 7 ，张力补偿的分析方法及应用在建筑混合结构 8 ，拉伸部队emulationaI分析的多级预应力锚索张拉施工方法 9 ，逆向分析方法的建设centrel张力的预应力空间结构

The synthesis of the pentacyclic skeleton of Et-743 and the construction of the five chiral centers thereof.1. The core pentacyclic skeleton of phthalascidin was constructed with L-dopa as the starting material via thirteen steps. First, two basic synthons, the C-1 functionalized tetrahydroisoquinoline compounds 8 and N-protected Z-dopa derivative 9, were prepared from L-dopa. They were coupled via amide bond to form the dipeptide compounds 10, which were the first key intermediates. Then the primary hydroxyl groups were transformed into the corresponding amino aldehydes 11 via Swern oxidation. Followed by the intramolecular Pictet-Spengler cyclization, the pentacyclic compounds 12 were synthesized.

五环骨架的构建及五个正确手性中心的确立：1.1我们以L-多巴为起始原料，经过多步官能团保护和转化合成了基本结构单元8然后和苯丙氨酸衍生物9，通过缩合反应生成酰胺中间体10，经Swern氧化得到醛化合物11，然后再次利用分子内改良的Pictet-Spengler反应一步构建c，d两环，得到五环骨架化合物12，最后，实现了21-位羰基向氰基的转化，得到了C-1位官能化的化合物14，化合物14不但具有和Et-743一致的五环骨架，而且分子中五个手性中心立体构型也与其完全相同：其中，3，位和13，位的手性中心由原料L-多巴带入，而1，位，11，位和21，位手性中心则通过不对称诱导而确立。

In view of the above factors, to a certain extent, affected the greenhouses of the application and promotion, plus the current bamboo, wood steel prices rising, the vast rural areas in urgent need of a low-cost, corrosion-resistant, resistant to moisture, anti-aging a new framework to shed Instead of the traditional bamboo, wood, steel materials, in the light of this, I units commissioned by the relevant departments, research institutions and the parties concerned under the guidance of experts, completed a "no-pillar greenhouses skeleton of" key project, supported by aircraft I developed a special formula units, the production of greenhouse skeleton without pillars of quality and cheap, quality higher than that of a steel frame, lower than the cost of bamboo, wood, the technical supervision departments test, the main performance indicators are as follows: the simulation of the actual scope: 5.8 - 6.8KN bending strength ≥ 3.3 KN compressive strength ≥ 20 KN water absorption ≤ 13

鉴于上述因素，在一定程度上影响了塑料大棚的应用与推广，又加之目前竹、木钢材价格不断上涨，现广大农村急需一种价格低廉、抗腐蚀、耐潮湿、抗老化的新型大棚骨架来代替传统的竹、木、钢材料，鉴于此，我单位受有关部门委托，在各方科研机构及有关专家的指导下，完成了《无支柱塑料大棚骨架机》的攻关项目，该机配以我单位研制的特殊配方、工艺生产的无支柱大棚骨架质优价廉，质量高于钢架，成本低于竹、木，经技术监督部门测试，主要性能指标如下：模拟实际受力范围：5.8-6.8KN 抗折强度≥3.3KN 抗压强度≥20KN 吸水率≤13

Being combining with products distribution in styrene oxidation, we propose the styrene epoxidation carry out with Ti metallacyclo intermediates, And at the same time Ti-ZSM-5 have properties both catalytic epoxidation and acid-catalysis, namely the skeletal Ti can catalyze styrene epoxidation to styrene oxide and the skeletal Ti and Al can provide Lewis acid site to cause the rearrangement of styrene oxide to phenylacetaldehyde rapidly, the solvolysis to glycols and the cleavage of C=C double bond. Ti-ZSM-5 can also provide Bronsted acid site simultaneously, which is also catalytic center for the solvolysis to glycols.

同时结合Ti-ZSM-5催化选择性氧化苯乙烯反应的产物分布结果，提出苯乙烯环氧化反应可能是通过金属有机环机理进行；Ti-ZSM-5同时具有催化环氧化和酸催化两种功能，其骨架钛可催化苯乙烯环氧化生成环氧苯乙烷，而骨架钛和骨架铝等可提供Lewis酸位使环氧苯乙烷迅速发生重排生成苯乙醛从而使其成为反应的主要产物，同时还可发生加成以及碳碳键的裂解等副反应：Ti-ZSM-5也提供Bronsted酸位，它也是生成加成产物的活性中心。

It was found that the tetrahedrally coordinated Ti in the titanosilicate molecular sieve was the main reason to arise H2O2 decomposition as well as the effect of acid centers of the catalyst.

结果表明，分子筛骨架Ti和其拥有的酸性位是造成H2O2在分子筛上分解的主要原因，非骨架Ti对H2O2分解的影响弱于骨架Ti.H2O2的无效分解直接影响反应物的转化效率。

ITQ-26 (INSTITUTO DE TECNOLOGIA QUIMICA number 26) is a new crystalline microporous material with a framework of tetrahedral atoms connected by atoms capable of bridging the tetrahedral atoms, the tetrahedral atom framework being defined by the interconnections between the tetrahedrally coordinated atoms in its framework.

ITQ-26(INSTITUTO DE TECNOLOGA QUMICA number 26)是新的结晶微孔材料，其具有通过能够桥联四面体原子的原子连接的四面体原子骨架，该四面体原子骨架通过其骨架中四面体配位原子之间的相互连接来界定。

ITQ-27 (INSTITUTO DE TECNOLOGíA QUíMICA number 27) is a new crystalline microporous material with a framework of tetrahedral atoms connected by atoms capable of bridging the tetrahedral atoms, the tetrahedral atom framework being defined by the interconnections between the tetrahedrally coordinated atoms in its framework.

ITQ-27(INSTITUTO DE TECNOLOGíA QUíMICA number27)是新型微孔晶体材料，其具有通过能够桥联四面体原子的原子连接的四面体原子骨架，该四面体原子骨架通过其骨架中的四面体配位原子之间的相互连接而确定。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。