马默斯

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

A long string of popular albums resulted, including Mein Liebeslied (2000), Napoli Adieu (2001), Drei Stimmen d'Amour (2001; co-featuring Mara Kayer and Francine Jordi), Mein Gefьhl (2002), Das Beste von Monika Martin (2002), Himmel aus Glas (2003), Eine Liebe Reicht fьr Zwei (2004), Ave Maria: Lieder zur Stillen Zeit (2004), Ein Kleines Glьck (2005), Schmetterling d'Amour (2005), Heute Fьhl' Ich Mich Wie Zwanzig (2006), and Aloha Blue (2007)- most of which were Top 20, if not Top Ten, hits in Austria and anywhere from Top 50 to Top 100 hits in Germany.

专辑的流行造成一长串，包括炒面Liebeslied（2000年），那不勒斯再见（2001年），科特迪瓦爱德雷伊之声（2001；合作具有马拉戈耶尔和弗朗辛霍尔迪），炒面Gefьhl（2002年），达斯Beste马丁冯莫妮卡（2002年），希默尔澳大利亚玻璃（2003年），Eine利伯Reicht黵Zwei（2004年），圣母颂：之歌楚Stillen宰特（2004），艾因KleinesGlьck（2005年），Schmetterling德爱（2005年），霍伊特Fьhl'非物质文化遗产密歇根魏Zwanzig（2006年），和阿罗哈蓝色（2007）-其中大部分是前20，如果不是前十名，在奥地利安打，任何地方从50强的前100点击在德国。

Pr., being the substance of everything liturgical in Bishop Sparrow, Mr. L'Estrange, Dr. Comber Dr. Nichols, and all former ritualists, commentators, and others upon the same subject; Mason, Thomas Cranmer; and various other works treating of the Reformation in England, especially in the reign of Edward VI.

公关，作为物质的一切礼仪，在主教麻雀先生l'疏远，精梳博士博士尼科尔斯，和所有前ritualists ，评论家，以及其他经同一主题；梅森，托马斯克兰默；和其他各种工程的治疗这项改革在英国，尤其是在腥风血雨的爱德华六。

Mr. Sawafiri stood in a disgusted crowd in Gaza City watching looters strip the sumptuous villa of Muhammad Dahlan, a former Fatah security chief and bitter rival of Hamas, who was not in Gaza.

Sawafiri先生站在加沙城令人做恶的人群中，眼睁睁看著打劫者掠夺穆罕默德达赫兰的豪华别墅，穆罕默德他是前法塔赫安全局局长，也是哈马斯愤恨的眼中钉，不过他不在加沙。

The Mabo decision refers to Eddie Mabo, who was a Murray islander from Torres Strait who had taken the government to court in order to establish that he had maintained native title rights to his traditional lands.

马博裁决》是指托雷斯海峡默累岛居民埃迪·马博为维护其对传统土地所有权而把政府告上了法庭。

MRS BELLINGHAM: He addressed me in several handwritings with fulsome compliments as a Venus in furs and alleged profound pity for my frostbound coachman Palmer while in the same breath he expressed himself as envious of his earflaps and fleecy sheepskins and of his fortunate proximity to my person, when standing behind my chair wearing my livery and the armorial bearings of the Bellingham escutcheon garnished sable, a buck's head couped or.

304贝林厄姆夫人：这家伙用种种笔迹给我写信，肉麻地恭维我是穿皮衣的维纳斯，说他深切地同情我那冻僵了的马车夫帕尔默，同时又表示羡慕帕尔默的帽子护耳、蓬蓬松松的羊皮外衣以及他能呆在我身边有多么幸运。也就是说，羡慕他身穿印有贝林厄姆家徽的号衣——黑色盾纹面上配以金线绣的雄鹿头。

This revised and reformed handbook of worship was largely the work of the Archbishop of Canterbury, Thomas Cranmer, and in his Preface, Cranmer explained that it was to provide common prayer in two senses of the word.

这一修订和改革手册的崇拜，主要是工作的坎特伯雷大主教托马斯克兰默，并在他的自序，克兰默解释说，它是提供共同祈祷，在两个意义上的字。

Hartshorne contends, however, that other philosophers and theologians have elaborated panentheistic doctrines of God, especially Alfred North Whitehead but also Nikolai Berdyaev, Martin Buber, Gustaf T Fechner, Mohammad Iqbal, Charles S Peirce, Otto Pfleiderer, Sarvepalli Radhakrishnan, Friedrich WJ von Schelling, Allan Watts, and Paul Weiss.

hartshorne争辩，不过，其他的哲学家和神学家阐述panentheistic上帝的教义，特别是曹绍伟北白石，但也尼古拉柏第雅夫，马丁布伯，古斯塔夫费希纳吨，穆罕默德伊克巴尔，查尔斯s皮尔士，奥托pfleiderer ， sarvepalli拉达克里希南，弗里德里希WJ通信公司冯谢林，署长瓦特，以及保罗韦斯。

Major Cities: Stockholm, Goeteborg, Malmo, Uppsala, Norrkoeping, Vasteras, Orebro, Linkoeping.

主要城市：斯德哥尔摩、哥德堡、马尔默、乌普萨拉、诺尔雪平、韦斯特罗斯、厄勒布鲁、林雪平。

MajorCities: Stockholm, Goeteborg, Malmo, Uppsala, Norrkoeping, Vasteras, Orebro,Linkoeping.

主要城市：斯德哥尔摩、哥德堡、马尔默、乌普萨拉、诺尔雪平、韦斯特罗斯、厄勒布鲁、林雪平。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。