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Results: The dissolution rate of the brucine and strychnine in micmpowder was significantly improved in contrast to powder.

结果:用桨法测定体外溶出度时,马钱子微粉中马钱子碱和士的宁累积释放度高于马钱子粉中马钱子碱和士的宁累积释放度。

Comparison of brucine and nitrogen oxides isobrucine in their anticancer and antioxidation effect.

马钱子碱与异马钱子碱氮氧化物抗肿瘤细胞生长及抗氧化损伤作用的比较。

The application of differential pulse polarography to brucine reaction product, having electroanalytical activity, with HNO_3 has been reported in this paper.

由于马钱子碱和硝酸反应后生成的产物具有电化学活性,因此,可以微分脉冲极谱法对马钱子碱进行测定。

Firstly, the apoptosis and proliferation of normal chondrocytes were observed by flow cytometry and MTT respectively after treated with Semen strychni、Brucine and Strchnine.

1用流式细胞仪及MTT法观察马钱子马钱子碱和士的宁对正常培养的软骨细胞凋亡与增殖的影响。

Methods The plasma balance dialysis was used. HPLC was performed for the quantitative determination of brucine, and then the protein binding rate of brucine in rats plasma was calculated.

采用大鼠血浆平衡透析法,HPLC法测定透析袋两侧溶液中马钱子碱的质量浓度,计算马钱子碱的血浆蛋白结合率。

Methods: The brucine and strychnine in the micropowder and powder of Semen Strychi were determined by HPLC to calculate the cumulative release at different time.

马钱子碱和士的宁为指标,用HPLC测定马钱子粉和马钱子微粉在不同时间马钱子碱和士的宁溶出的量,计算累积释放率。

Brucine and its liposome could inhibit the growth of transplanted solid tumor and the inhibitory effect of its liposome is much stronger than that of brucine.

马钱子碱及其脂质体有显著的抑制荷瘤小鼠肿瘤生长作用,马钱子碱脂质体抗肿瘤作用明显强于马钱子碱。

A new method for the determination of vauqueline by using the flow injection chemiluminescence method is presented.

报道一种微量测定马钱子碱的新方法,该方法是基于高锰酸钾对马钱子碱的氧化作用,建立了微量马钱子碱的流动注射化学发光分析法。

Methods:The study of this subject is for making sure the function of decreasing toxicity on the compatibility of Nux vomica powder through experiment of acute toxicity and the little white mice s activity.

目的:为了验证马钱子散的配伍减毒增效作用,进行了马钱子散的配伍减毒作用实验研究和马钱子散的配伍增效作用实验研究。

Results Brucine and its liposome had significant inhibiting effect on transplanted tumor growth in mice. Inhibitory rates of brucine on Heps were 35.05% [1.61mg/], 43.70% [3.23mg/], and 46.09% [6.46mg/], while of its liposome on Reps was 45.41% 1.61mg/1 and 58.19% [3.23 mg/, respectively. The inhibitory rate of brucine on S180 was 37.59% [1.61 mg/], 36.13% 3.23mg/, and 38.87% [6.46 mg/, while of its liposome on S180 was 53.00% [1.61mg/] and 48.37% [3.23mg/], respectively. However, both of them had no distinct effect on prolonging the life of mice with transplanted tumor.

结果 马钱子碱及其脂质体能有效抑制实体瘤模型荷瘤小鼠体内肿瘤生长,1.61、3.23、6.46mg/马钱子碱对Heps小鼠的抑瘤率分别为35.05%、43.70%和46.09%,而1.61、3.23mg/马钱子碱脂质体的抑瘤率分别为45.41%和58.19%;1.61%、3.23、6.46mg/马钱子碱对S180小鼠的抑瘤率分别为37.59%、36.13%和35.57%,而1.61和3.23mg/马钱子碱脂质体的抑瘤率分别为53.00%和48.37%,明显高于马钱子碱;但两者对腹水瘤模型荷瘤小鼠的生存时间均无延长作用。

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