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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞,导致细胞生长的抑制和凋亡罗伯托利,斯特凡Purgato ,苏埃洛卡默琳,拉菲尔Fronza ,梅奥尼博洛尼亚,西蒙娜Alboresi ,莫妮卡弗兰索尼,罗伯托Corradini ,斯特凡诺斯福尔扎,安德烈Faccini ,杰森先生Shohet , Rosangela Marchelli ,和安德烈Pession儿科,博洛尼亚大学,圣' Orsola -马尔皮基医院,博洛尼亚,意大利;有机部和工业大学化学帕尔马,帕尔马,意大利和3Center的细胞和基因治疗,德州儿童癌症中心, Baylor医学院,得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞,针对一个独特的序列反义DNA链的第2外显子,并与在MYCN 其氨基端为核定位信号肽。

Bishop Raffaello Martinelli, a close collaborator with Cardinal Joseph Ratzinger in the Congregation for the Doctrine of the Faith, was ordained by the Pontiff to lead the Diocese of Frascati, close to Rome.

方济各科波拉Franco Coppola为驻布隆迪大使,拉斐尔马尔蒂内利Raffaello Martinelli被当选为弗拉斯卡蒂主教,乔治科尔贝利尼Giorgio Corbellini蒙席被任命为宗座劳动办公室主任。

Present: Didier Grange; Sharon Alexander-Gooding; Zohar Aloufi; Nestor Bamidis; Marilyn Bier: Kim Eberhard; Mark Greene; Fred Van Kan; Bert De Keyser; Nancy Marrelli; Chantal Ménard; Robert Nahuet; Chiyoko Ogawa; Trudy Peterson; Lars Sandberg; Kazuko Sasaki; Wladyslaw Stepniak; Shelley Sweeney; Katherina Tiemann; Margaret Turner.

与会者:狄迪尔·格朗齐、莎伦·亚历山大·谷丁(ARMA,Association of Records Managers and Administrators,档案管理人员与行政人员协会)、佐哈·阿劳菲、内斯特·巴米迪斯、玛丽琳·毕尔,基姆·爱伯哈德、马克·格林尼、弗雷德·范·坎、伯特·德·基瑟、南希·马瑞利、常塔尔·米纳德、罗伯特·那休伊特、小川千代子(Chiyoko Ogawa?

He was under Kleber at Marchiennes at the battle of Mont-Palissel, where a ball from a biscaien broke his arm.

他在克莱贝尔部下到过马尔什安,并在蒙巴利塞尔一战中被铳子打伤了胳膊。

He's really grown – Tom Felton was a chubby-cheeked imp as Harry's rival Draco Malfoy in Harry Potter and the Philosopher's Stone, but in the new film, he's put on a growth spurt and even more angst than everybody else, and glowers at Potter (the 5' 5" Daniel Radcliffe) from his 6' 1" height

当初在《哈利波特与魔法石》中汤姆扮演的德拉科·马尔福还是一脸肉肉的小屁孩儿样,在最新一部的电影中,他却已经长成最激进的一愤青,而且一米八五的身高也让他在仅一米六五的&哈利波特&丹尼尔(咳,浓缩的都是精华……)面前占尽优势。

The nine-time Grammy Award winning Marsalis is one of the headliners at this year's festival. Other famous performers include Neil Young, Etta James, Tony Bennett, Bonnie Rait and Sugarland. The Dave Matthews Band is also performing.

第九届格莱美奖得主马尔沙利,是今年盛典大牌人物之一,其它的著名人物还包括:尼尔-杨、爱塔-詹姆斯、托尼-贝内特、保尼-里达以及休格兰特等,大卫-马修斯乐队也参加了演出。

On June 5, Tom Felton guest starred on "The Ministry of Mayhem" along with his cronies, Jamie Waylett and Josh Herdman.

在六月5号,汤姆·费尔顿(德拉科·马尔福的饰演者)应邀与他的朋友杰利·威尔特、乔森·赫尔曼一起参加了&The Minsitry of Mayhem&播出的节目。

Herr Würgler claimed that FIFA President Sepp Blatter had approached Christoph Malms and told him in no uncertain terms that if ISL wanted to keep FIFA's business, Jean-Marie Weber had to retain his job at the company.

维尔格勒先生表示,国际足联主席布拉特曾经找到马尔姆斯,毫不含糊地告诉他说,如果ISL公司希望继续和国际足联做生意,就必须把让-马利韦伯留在公司。

The Mavi Marmara led two other Turkish ships out of the Turkish Mediterranean port of Antalya.

马维为首的另外两名土耳其马尔马拉船出了土耳其地中海安塔利亚港口。

They are: Idi Amin, of Uganda, now enjoying life as a guest of the Saudis; Jean-B del Bokassa, of the Central African Republic, known to the people of that country as the Ogre of Berengo; Wojciech Jaruzelski, the Soviets' Polish puppet; Nexhmije Hoxha, who (with, until his death, her husband, Enver) ruled Albania for nearly fifty years; Jean-Claude Duvalier, who got run out of Haiti in 1986; Mengitsu Haile Mariam, the Marxist-Leninist dictator of Ethiopia; and Mira Markovic, the wife of Slobodan Milosevic, who is currently on trial in The Hague for crimes against humanity.

他们是:乌干达的阿迪·阿明,现在作为沙特阿拉伯的客人依然在享受生活;中非共和国的让-贝德尔·博卡萨(Jean-B del Bokassa),以&食人的皇帝&而著称于这个国家的人民;沃依切赫·雅鲁泽尔斯基,苏联在波兰的傀儡;涅奇米叶·霍查,她统治了阿尔巴尼亚近五十年的时间;让-克劳德·杜瓦利埃(Jean-Claude Duvalier),1986年出逃海地;门格斯图·海尔·马里亚姆,埃塞俄比亚的马列主义独裁者;和米娜·马尔科维奇,目前因为反人类罪被海牙法庭审判的斯洛博丹·米洛舍维奇的妻子。

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