香豆素

Part 2. Annulation reaction of 3, 4-dichlorocoumarin (1) and 3, 4-dichloromaleimide (8) by a new general annulation strategy developed in this group with 2-phenylbenzofuran (15), 3-phenylbenzofuran (16), 2, 5-diphenyloxazole (17), 2, 5-diphenylthiazole (18), 2-methyl-4-phenylthiazole (19) and 2, 3-dimethoxy-1, 3-butadiene (40) were investigated.

二。在本课题组前一阶段提出的从二氯代环烯酮与1，1-二芳基乙烯的光化反应以及光化反应中得到的环丁烷产物的连续电环化反应对3，4-二氯马来酰亚胺以及3，4-二氯香豆素进行增环反应的工作基础上，研究了3，4-二氯香豆素（1）和3，4-二氯马来酰亚胺（8）与5个α-苯基取代的环烯烃2-苯基苯并呋喃（15），3-苯基苯并呋喃（16），2，5-二苯基噁唑（17），2，5-二苯基噻唑（18），2-甲基-4-苯基噻唑（19），以及一个丁二烯——2，3-二甲氧基丁二烯（40）进行的芳香族增环反应。

Density functional theory has been successfully used to predict the kinetic properties and electronic structure of coumarin and spectral characteristics, and it can effectively reduce the blindness and unnecessary waste in synthesis and application of coumarin.

密度泛函理论已成功用于预测反应动力学特性和香豆素的电子结构和光谱特性，可以有效地减少香豆素合成和应用中的盲目性和不必要的浪费。

2 Three ketocoumarin dyes and two coumarin dyes with heterocyclic substituent were prepared.

在参考文献的基础上，合成了5个香豆素染料(包括二个杂环取代的香豆素)。

Seven 7-styrylcoumarins were synthesized by palladium-catalyzed Heck reaction of coumarin diazonium salts with substituted styrenes.

采用钯催化香豆素重氮盐的Heck反应合成了七个7-位苯乙烯基取代香豆素化合物，该方法反应条件温和且收率较高。

Because of the property of donative electron of the methoxy group and the participation of the carbonyl group of the coumarin into the complexation proces...

研究表明，由于在香豆素的6 位上引入一个甲氧基，对应的主－客配合物的稳定常数较（7－甲氧基－4－亚甲基）香豆素基－单氮杂－ 18－冠－6（ MMC－ MAC（O5））与阳离子配位的稳定常数又有所增高。

The results show that: 27 compounds were identified at 600℃, and most of them were alkenes, alkanes, acids, alcohols and phenolic substances; geraniol was identified, and its relative content was 3.6, which shows that geranyl 8-methoxycoumarin-3-carboxylic acid ester can release a certain amount of geraniol at smoke temperature; geranyl 8-methoxycoumarin-3-carboxylic acid ester can improve and modify the flavor, enhance the notes of sweet aroma and bean aroma, and reduce the biting taste of cigarette smoke.

结果表明，600℃时，8-甲氧基－香豆素－3-甲酸香叶酯的热解产物中共鉴定出27种成分，主要为烯类、烷类、酸类、醇类、酚类；鉴定出香叶醇，且相对峰面积3.6，说明8-甲氧基－香豆素－3-甲酸香叶酯能在卷烟燃吸温度下释放出一定量的香叶醇；8-甲氧基－香豆素－3-甲酸香叶酯具有改善和修饰卷烟香气，增加甜韵和豆香香韵，减轻刺激性的作用。

The results have indicated that the introduction of electron-donating methoxy or electron-withdrawing cyano-group at the 7-position of 3-phenylcoumarins caused a bathochromic shift for both absorption and fluorescence spectra. The phenyl group at the 4-position derivative has a hypsochromic shift for both absorption and fluorescence spectra.

结果发现，在3-苯基香豆素的7-位引入给电子基团甲氧基或吸电子基团氰基均使它们的吸收光谱和荧光光谱产生红移，4-苯基香豆素的衍生物的吸收光谱和荧光光谱均产生蓝移。3-苯基香豆素衍生物与4-苯基香豆素的衍生物的基态和激发态的电子转移方向相反。

The article introduces the anti-tumor and other pharmacologic effects of the isocoumarin s, reviews the methods of synthesizing isocoumarin s, and places an emphasis on introducing and comparing such methods of synthesizing syntheticroutes of dihydro isocoumarin s as ozone oxidation, organic metal sythesis, catalytic oxidation and so on.

介绍了异香豆素类化合物在抗癌和其他药理方面的作用，综述了异香豆素类化合物的合成方法，着重介绍其中的二氢类异香豆素化合物的臭氧氧化法、金属有机合成法、催化氧化法、分子间成环缩合法等合成方法，并进行了比较。

Seauckthorn juice can be appropriate drinks afer the diluting, which could block the N-nitroso Synthesis and also can block N-dimethylnitrosaminewhich can lead to cancer.The flavone of Seabuckthorn contains coumarin, isocoumarin, furan coumarins, lignin, as well as bitter polyphenols, 5 - serotonin, which are benefited for anti-cancer.

沙棘汁经稀释成宜引用的浓度后，能阻断N-亚硝酸的合成，另外沙棘汁对致癌物N二甲基亚硝胺也有阻断与防护的作用；沙棘黄酮中含有香豆素，异香豆素，呋喃香豆素，苦木素以及多酚类，5-色胺等具有综合抗癌作用的成分。

In others with double-armed receptors, the probes 4-(N,N-bisacetoxyethylaminomethyl)-7-methoxycoumarin.(B3) and 4-N,N- bis(diethylaminodithiocarboxyethyl aminomethyl-7-methoxycoumarin (B4) with pronounced fluorescence enhancement response to special heavy and transition metal ions were proposed as PET mechanism; for those with double-armed receptors following ICT mechanism, their performances are influenced by not only the structure of the receptors but also the attaching position of it.

双臂香豆素类荧光分子探针体系中，我们研究了含有不同杂原子的识别基团对PET型荧光探针识别性能的影响，优化了探针的选择性，得到了可以选择性识别某种过渡金属和重金属离子的荧光增强型分子探针4--7-甲氧基香豆素(B3)和4--7-甲氧基香豆素B4而在ICT型荧光探针的研究中，我们发现具有不同杂原子的识别基团可以对识别性能产生影响的同时，连接位置的改变也对识别能力有很大的影响。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失