香草酸

The compound HCB-01712-2 has been isolated from the broth of Claviceps HCB-01712,by the analyses of its physico-chemical properties,UV,ESI-MS and NMR spectra data,the structure of HCB-01712-2 has been identified as methyl vanillate.

从麦角菌(Claviceps sp。)HCB-01712的发酵液中分离纯化得到化合物HCB-01712-2，经理化分析、紫外吸收、质谱及核磁共振谱分析，确定该化合物为香草酸甲酯。

The dimerization of homovanillic acid by hydrogen peroxide in the presence of manganese tetrasulfonatophthalocyanine has been adapted to the determination of hydrogen peroxide in rainwater.

在四磺基锰酞菁存在下，高香草酸与过氧化氢作用可形成强荧光二聚体，由此建立的测定水溶液中过氧化氢的荧光方法可用于本地区雨水样品的分析。

Already know, attention deficit hyperactivity disorder in children with urinary 3-A 4 Phenylethanol hydroxyl oxygen content decreased in cerebrospinal fluid homovanillic acid homocysteine decreased, and both are catecholamine metabolites.

已经知道，多动症患儿尿中3一甲4一氧羟苯乙醇含量减少，脑脊液中同型香草酸含量降低，而二者都是儿茶酚胺的代谢产物。

Results At 2 h after damage in cerebral cortex 5-hydroxyindolecetic acid (5-HIAA) elevated remarkably; At 8 h after da-mage 5-hydroxytryptamine (5-HT), homovanillic acid elevated; but there was no obvious change on norepinephrine and 3,4-dihydroxyphenyl acetic acid.

结果 大脑皮质运动区在损伤后2小时5-羟吲哚乙酸（5-HIAA〕明显升高；8小时后5-羟色胺(5-HT)、高香草酸升高；去甲肾上腺素及3、4-双羟苯乙酸变化不明显。

Results: Both Pur and Hup-A improved learning memory ability of I/R mice, the effect of Pur group was better and the effect of combination group was the most significant. Both Pur and Hup-A decreased neuron apoptosis and raised content of monoamine nervous transmitter of I/R mice. The cortex neuron apoptosis rate in combination group was lower than that in Hup-A group,the homovanillic acid level of cerebral cortex in combination group was higher than that of Pur group.

结果：Pur（120 mg/kg）或Hup-A（400 μg/kg）都可提高I/R小鼠的学习记忆成绩，Pur组的作用优于Hup-A组，联合用药组（Hup-A 200 μg/kg+Pur 60 mg/kg）作用最强；各用药组都可降低大脑皮层细胞凋亡率，升高大脑皮层某些单胺类递质水平，其中，联合用药组的大脑皮层细胞凋亡率低于Hup-A组，大脑皮层高香草酸水平高于Pur组。

MAIN OUTCOME MEASURES: The contents of monoamine neurotranmitters of norepinephrine, adrenalin, dopamine and 5-serotonin (5-HA) and its metabolites of DHPR, 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid in the striatum and marginal area of brain in rats were observed.

主要观察指标：大鼠纹状体和脑边缘区单胺类递质去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺及其代谢产物3，4-二羟苯乙二醇、5-羟吲哚乙酸、高香草酸的含量。

The dopamine release in vivo was monitored by fast cyclic voltammetry and the concentrations of DA and its metabolites dihydroxy-phenylacetic acid and homovanillic acid were determined by high performance liquid chromatography electrochemical detection in the process study. In addition, the effects of some traditional Chinese herbs and related marine drug on behavioral changes were also evaluated in order to provide some suggestive clue for rational drug design of anti-Parkinon's disease .

许多因素都参与PD的DA能神经元的死亡，所以，本研究在制备PD动物模型的基础上，应用国内率先引进的快速周期伏安法检测设备在体动态监测DA的释放，同时应用另一种电化学检测技术—高效液相色谱电化学检测法离体检测DA及其代谢产物二羟苯乙酸和高香草酸的含量，结合行为学测定及其它方法，研究了雌激素和铁在PD发病中的作用，以及一些药物，如吲哚醌、牛磺酸、铁离子螯合剂、胆囊收缩素（CCK-8）、乌鸡白凤丸有效成份、大豆异黄酮及海洋酸性寡糖HSH971，对DA能神经元的影响，从DA能神经递质角度对PD的发病机理提供进一步的实验依据，并为PD的预防和治疗提供新的干预措施。

MAIN OUTCOME MEASURES: Content of monoamine transmitter such as levarterenol, adnephrin, dopamine, indoleacetic acid, homovanillic acid and 5-serotonin.

主要观察指标：测定各组大鼠脑组织单胺类神经递质去甲肾上腺素、肾上腺素、多巴胺、吲哚乙酸、高香草酸和5-羟色胺的含量，并进行组间对比。

In the pretreatment group, Bak Foong Pill extracts were given for 14 days prior to MPTP. Immunostaining of tyrosine hydroxythase was used to observe the damage of dopamine neurons, and of Bax to detect the protein levels of Bax. High performance liquid chromatography-electrochemical detection was used to investigate the contents of DA and its metabolites dihydroxy-phenylacetic acid and homovanillic in the Str.

给予BFP预处理后，用酪氨酸羟化酶免疫组织化学法观察黑质神经元的变化；同时应用免疫组织化学法检测Bax蛋白表达；应用高效液相-电化学方法检测纹状体巴胺及其代谢产物二羟基苯乙酸和高香草酸的含量变化。

The plasticity of NSCs was detected by the differentiating test. HESCs were induced into dopaminergic neurons by means of adding Sonic Hedgehog Peptide and fibroblast growth factor eight (FGF8) early under the condition of mocked microenvironment and different development stage of dopaminergic neurons in vivo ,meanwhile made comparison with traditional method . The marker of dopaminergic neurons was tested by immunocytochemistry and RT-PCR, the content of dopamine and its derivation homovanillic acid were measured by HPLC-ECD.

模拟体内多巴胺神经元分化发育的不同阶段及微环境，采用早期添加音猥因子及成纤维细胞生长因子-8(FGF8)的方法，诱导hESCs定向生成多巴胺能神经元，并与传统的诱导方法相比较，免疫荧光细胞化学和RT-PCR法检测多巴胺能神经元的标志，高效液相色谱法检测诱导后细胞及细胞培养上清液中多巴胺及其代谢产物高香草酸的含量。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。