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Results: The PCNA mean labelling index was 48.84%± 13.63%, and the apoptotic labelling index was12.26‰± 5.20‰. The Kaplan-Meier survival curves showed that the postoperative survival time of the patient was shorter when the tumor infiltrated to the adventitia of esophagus,with lymph node metastasis, without keratinization, PI ≥ 40% or AI<10‰. Using forward multivariate Cox regression analysis, only the parameters of pN category and PI could be verified as independent prognostic factors.

结果:36例手术切除的食管鳞癌组织平均PCNA表达指数(PCNAlabellingindex,PI)为48.84%±13.63%,细胞凋亡指数(apoptosisindex,AI)为12.26‰±5.20‰;PI升高与患者年龄小、分化程度低、有淋巴结转移和肿瘤进行性浸润呈正相关,而AI升高与分化程度高、角化明显呈正相关;绘制Kaplan-Meier生存曲线,发现病变侵及食管外膜、有淋巴结转移、无角化、PI≥40%或AI<10‰的患者术后生存率明显降低;COX比例风险模型分析,发现只有淋巴结转移和PI是影响预后的独立因素。

To explore the biomarkers for differential diagnosis of esophageal squamous cell carcinoma cells between carcinoma tissue and metastatic lymph nodes,laser capture microdissection was used to separate them.

分析食管鳞癌转移淋巴结中鳞癌细胞与食管鳞癌组织中鳞癌细胞的蛋白质的表达差异,获取鉴别两者的分子标志物。

AIM: To detect the differentially expressed genes in the process of esophageal carcinoma induced by nitrosamine, and analyze the property of gene expression at different stages, especially the relationship between differentially expressed genes and DNA methylation.

摘要目的:通过基因芯片技术检测亚硝胺诱导食管癌变过程中,食管组织基因表达的差异,分析不同阶段基因表达的特点以及基因差异表达与DNA甲基化的相关性。

The carcinoma of esophago lymph vessel in periphery areas provid conditions for cancer cell to shift.

e-cadherin、β-catenin在食管癌细胞中的表达减少,推测使食管癌细胞间的粘附能力减弱,促进了癌细胞的转移。

Methods Healthy Sprague-Dawley rats received basal ovalbumin-sensitized combined with intra-esophageal mucosal acid exposure. The neuronal expressions of c-fos proto-oncogene were detected with immunohistochemical counter-staining and computerized color image analyzer.

采用腹腔注射鸡卵清蛋白基础致敏联合食管酸灌注的方法处理SD大鼠,并采用免疫组织化学方法和显微图像分析技术评价内脏高敏感性-食管化学刺激大鼠模型的可靠性。

Objective To investigate the esophageal function and laryngeal signs in globus hystericus and determine if significant relation existed between globus and UES pressure.

目的 观察咽异感症患者的食管压力变化及喉部特点,探讨咽异感症与食管上括约肌(upper esophageal sphincter,UES)压力的关系。

Methods:Two hundred patients with GERD suffered from asthma attack were reviewed retrospectively who had been treated by the stretta radiofrequency treatment under endoscope with intravenous anesthesia(100 cases) and LNF with general anesthesia(100 cases) from January 2008 to December...

对2008-01/2008-12 200例胃食管反流患者在静脉麻醉下行经食管射频治疗术(100例)和在全麻下腹腔镜胃底折叠术(100例)中的&哮喘&发作患者的处理进行总结。

Objective:To explore the anesthesia countermeasure of asthma attack among the stretta radiofrequency treatment under endoscope and laparoscopic nissen fundoplication for patients with gastroesophageal reflux disease.

目的:总结胃食管反流病并发&哮喘&的患者在静脉麻醉下经食管射频治疗术和在全麻下腹腔镜胃底折叠手术中&哮喘&发作的应对措施。

Then the analyses of detected results and the TNM stagings or the histological classifications of the carcinoma were statistically analyzed in SPSS.

结果:p53功能失活率为64%,明显高于p53基因突变率49%。p53功能失活和食管鳞癌的TNM分期有关,分期越高,p53功能失活率越高;p53功能失活和食管鳞癌的组织学分级有关,分级越高,p53功能失活率越高。

Nicotine can relax the lower esophageal sphincter, a muscle between the esophagus and stomach, allowing the acidic contents of the stomach to splash back into the esophagus.

尼古丁可以放松下部食管括约肌即位于食管与胃之间的肌肉,使胃的酸性内容物反流到食道。

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