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The psammoma body mineralization in meningioma is a common type of mineralizationThe analysis of the mineral composition may provide some support information in finding the reason of happening and developing of the diseaseThis paper focuses on the concentric layered structure mineralization in meningiomas, using mineralogical methods, such as HRSEM, ESEM, EDAX, EPMA, HRTEM, XRD and FTIR to systematically investigate the mineral composition, structure and shape of the minerals in psammoma bodies in meningiomasWe have devised a method for preparing the silicon wafer sheet which was used for the ESEM insitu observations and analysisIn this study, we first got the ESEM and HRTEM images of the initial mineralization phase of meningiomasThese images showed that in the early stage of psammoma body mineralization in meningiomas, many mineralized balls composed of octocaphosphate were precipitated on the collagen fibersThese balls continued to grow and aggregate, and were gradually hydrolyzed to become the dahlliteThe continued development of mineralization resulted in the mineralized collagen fibersThe study revealed that the concentric layered structure of the psammoma bodies in meningiomas is formed by the spiral arrangement of the mineralized collagen fibers on which the mineralized grains precipitated.

砂粒体矿化是脑膜瘤中常见的矿化类型,对其形成机理和矿物成分的分析可能会对肿瘤发生、发展的研究提供辅助信息。该研究选取人脑膜瘤中的砂粒体矿化作为研究对象,采用偏光显微镜、环境扫描电镜及能谱、X射线衍射仪、高分辨透射电镜和电子探针对样品的形貌、结构和成分进行测试分析,并以此为依据探讨脑膜瘤中砂粒体的形成机理。研究结果表明矿化的初期为沉淀在胶原纤维上的矿化小球,成分为磷酸八钙;矿化小球不断生长聚集,并逐步水解为碳羟磷灰石晶体,矿化的不断发展致使胶原纤维也发生矿化。砂粒体的同心层状构造是由螺旋状排列的矿化胶原纤维及沉淀在其上的矿化颗粒组成的集合体,而不是多数研究中所述:砂粒体是以坏死细胞残骸为中心由内至外的同心层沉淀。

The BrdU labelled cells were mainly distributed in the subgranular zone.

BrdU阳性细胞主要分布在齿状回颗粒下层。

Fig 4GM-CSF expression of human fetal liver,positive granular in the endothial cell of sublobular vein.

图 4胎肝GM-CSFmRNA表达,可见肝小叶下静脉内皮细胞内有阳性颗粒。

The gray value of SP and CGRP radioactive particles in bilateral spinal trigeminal caudal subnucleus in rats were detected by immunohisto- chemisrty while obvious damages in trigeminal neurocytes on the injected side were confirmed.

在确认实验侧三叉神经节细胞出现明显破坏的同时,采用免疫组织化学技术,检测大鼠双侧三叉神经脊束核尾侧亚核内P物质和降钙素基因相关肽免疫阳性颗粒的灰度值。

A colloidally stable suspension of nanoparticles was incubated on sheep synovial cells in vitro for 3, 24, 72, and 120 hours.

将纳米颗粒胶质的稳定悬浮液与羊滑膜细胞体外培养3、24、72和120小时。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

The main reason for the blindness is a contamination of a plenty of the untransparent granules with a size of 0.3um in diameter from the epithelial cells.

随着晶状体上皮细胞的不断解体,这些不透明颗粒大量涌进并充满了晶状体基质,最后导致先天性失明。

Mesenteric venular inner-diameter, velocity of red blood cells in venules, numbers of leukocytes rolling and adhesion, FITC-albumin efflux and mast cell degranulation were determined by an inverted microscope.

用活体微循环观测技术,观察肠系膜细静脉血管内径和红细胞流速、滚动和黏附白细胞数、细静脉白蛋白漏出的动态变化和血管外周肥大细胞脱颗粒。

When being acupunctured, the related mast cells will be activated to discharge particles.

当针刺穴位时,穴位处的肥大细胞被激活,产生脱颗粒反应。

The ultrastructure of normal guinea pig papillary muscle cell showing the sarcomere and light dark band were clear, mitochondria and glycogenosome were abundant, and mitochondrial cristae and membrane were clear.

正常豚鼠乳头状肌细胞在透射电镜下显示肌节排列整齐,细胞核周线粒体和糖原颗粒含量非常丰富,且线粒体嵴和膜清晰可见。

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