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METHODS AND RESULTS: Adherent platelets express substantial amounts of SDF-1 and recruit CD34+ cells in vitro and in vivo. A monoclonal antibody to SDF-1 or to its counterreceptor, CXCR4, inhibits stem cell adhesion on adherent platelets under high arterial shear in vitro and after carotid ligation in mice, as determined by intravital fluorescence microscopy.

方法和结果:在体和离体的粘附血小板表达大量SDF-1、募集CD34+细胞,在体荧光镜下可见,在小鼠颈动脉结扎后、离体条件下的动脉内高剪切应力时,SDF-1或其相应受体的单克隆抗体-CXCR4抑制干细胞粘附于血小板上。

A monoclonal antibody to SDF-1 or to its counter receptor, CXCR4, inhibits stem cell adhesion on adherent platelets under high arterial shear in vitro and after carotid ligation in mice, as determined by intravital fluorescence microscopy.

采用活体荧光显微镜,对颈动脉结扎后小鼠和体外的高剪切力动脉进行研究,结果发现SDF-1的单克隆抗体或其反受体CXCR4,抑制干细胞黏附在相互黏附的血小板上。

With the system, in vivo experiments were performed and the result proved the validity and feasibility of this approach. The result can be presented like this: the mean WSR value of common carotid artery from healthy adults is between 150~350s-1, and the max WSR value is between 450~750s-1; with comparing the WSR value from a male who is suffering from the internal carotid artery straitness with the natural range of WSR, a phenomenon was found that his max and mean WSR value are both smaller than the natural value evidently.

并且利用该系统进行了大量的在体实验研究,得到了相应的结果并验证了该方法的有效性及可行性,该结果显示:健康成年人的颈总动脉的血管壁剪切率平均值范围为150~350s-1,最大值范围为450~750 s-1;将患有颈内动脉狭窄的患者的血管壁剪切率与正常范围比较发现,其血管壁剪切率的最大值及平均值均显著小于正常范围。

Femoral plaques confound the association of circulating oxidized low-density lipoprotein with carotid atherosclerosis in a general population aged 35 to 55 years: the Asklepios Study.

在年龄在35至55岁的普通人群中的 Asklepios 调查过程中发现股动脉斑块混淆循环氧化低密度脂蛋白与颈动脉斑块的相关性

Results: of 52 cases, a total of 33 intracranial aneurysms were detected by the application of volume viewer, which clearly displayed the body, neck and parent artery of intracranial aneurysms, and showed the aneurysms relation with peripheral vessels and cranioaural In 52cases, 8 can of cerebral vascular malformations showed the form, the size and the hemisphere of cacogenesis cerebral vessels, as well a the amount of feeding artery and draining vein.

结果:52例中,脑动脉瘤33例,16层CT容积成像清晰显示所有动脉瘤的形态、大小、生长方向、瘤颈特征及其与载瘤动脉的关系、瘤体与相邻血管和颅骨的三维结构关系,优于DSA脑血管畸形8例,16层CT容积成像并显示畸形血管团的形态、范围大小以及供血动脉、引流静脉的形态及数量。

Objective To study the Changes of extracranial carotid arteries and proper palmar digital arteries in type 2 diabetic patients with cerebral infarction and its risk factors and to provide clinical index for the prophylaxis of ischemic cerebrovascular disease .

目的 探讨 2 型糖尿病性脑梗死患者颈动脉颅外段及指动脉的病变特征及其危险因素,以指导临床及时采取正确有效的干预措施,预防脑血管病的发生。

Its insertion was mainly composed of tendinous tissue, which was spaned by the lower trunk of brachial plexus.

小斜角肌的血供有2种类型:(1)从锁骨下动脉直接发出的分支,占63%;(2)来自颈深动脉的分支。

Among all persons who finished questionnaire 21.68% were resident physician,36.95% were attending physician, 25.65% were vice chief physician/chief physician; the most common cardiovascular disease in the investigated persons hospitals were angina (55.42%),stroke(38.17%), myocardial infarction(28.70%), heart failure (28.24%), hypertension (28.24%); as for early vascular disease detection methods,57.40% of investigated persons thought artery endothelial function examination,46.72% thought angiography, pulse wave velocity measurement and carotid intima-media thickness measurement were 40.61% and 31.76%;76.49% and 53.89% of the investigated persons thought angiotension converting enzyme inhibitor and statins could revert early vascular disease;96.79% of the investigated persons thought promotion early vascular disease detection strategy could help for reducing total burden of cardiovascular disease in our country;78.47% of the investigated persons thought early vascular disease detection methods should be easily used and non-invasive.

被调查者所在医院最常见心血管疾病顺序分别心绞痛55.42%,脑卒中38.17%,心肌梗死28.70%,心力衰竭28.24%,高血压28.24%;关于血管病变早期检测57.40%的被调查者认为通过动脉内皮功能测定,认为通过血管造影者占46.72%,认为通过脉搏波速度和颈动脉内膜中层厚度测定者分别占40.61%和31.76%;分别有76.49%和53.89%的被调查人群认为血管紧张素转换酶抑制剂和他汀类药物能够逆转早期血管病变;96.79%的被调查者认为推广血管病变早期检测技术有利于降低我国心脑血管疾病总体负担;78.47%的被调查者认为用于推广的早期血管病变检测技术应该是操作方便和无创伤。

Among all persons who finished questionnaire 21.68% were resident physician,36.95% were attending physician, 25.65% were vice chief physician/chief physician;the most common cardiovascular disease in the investigated persons hospitals were angina (55.42%),stroke(38.17%),myocardial infarction(28.70%),heart failure(28.24%), hypertension(28.24%);as for early vascular disease detection methods,57.40% of investigated persons thought artery endothelial function examination,46.72% thought angiography,pulse wave velocity measurement and carotid intima-media thickness measurement were 40.61% and 31.76%;76.49% and 53.89% of the investigated persons thought angiotension converting enzyme inhibitor and statins could revert early vascular disease;96.79% of the investigated persons thought promotion early vascular disease detection strategy could help for reducing total burden of cardiovascular disease in our country;78.47% of the investigated persons thought early vascular disease detection methods should be easily used and non-invasive.

被调查者所在医院最常见心血管疾病顺序分别为心绞痛55.42%,脑卒中38.17%,心肌梗死28.70%,心力衰竭28.24%,高血压28.24%;关于血管病变早期检测57.40%的被调查者认为通过动脉内皮功能测定,认为通过血管造影者占46.72%,认为通过脉搏波速度和颈动脉内膜中层厚度测定者分别占40.61%和31.76%;分别有76.49%和53.89%的被调查人群认为血管紧张素转换酶抑制剂和他汀类药物能够逆转早期血管病变;96.79%的被调查者认为推广血管病变早期检测技术有利于降低我国心脑血管疾病总体负担;78.47%的被调查者认为用于推广的早期血管病变检测技术应该是操作方便和无创伤。

The Division of Neurology is primarily dedicated to teaching and research in neurology including molecular aspects of xenobiotic enzymes, epilepsy, percutaneous carotid and vertebral artery angioplasty, In vitro and in vivo experimental studies on neuroprotective effects of neuropeptides during focal cerebral ischaemia, cardiovascular and autonomic complications during the acute stage of stroke.

神经学分部主要致力于神经学的教学与研究,其研究领域包括异生化合酶类的分子相,癫痫,颈动脉和脊椎动脉血管成形术,脑局部缺血中神经肽的体内和体外神经保护,急性中风时的心脏血管和自发的并发症等。

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