鞘氨醇

Results Two compounds were isolated from D. diandra. Theirs structures were identified as 6-carboxymethy1-5,7,4'-trihydroxyflavone and l-O-β-D-glucopyranosyl-(2S,3R,4E,8E)-Z-N-(2'-hydroxypalmitoyl) octadecasphinga-4,8-dienine(soya cerebroside Ⅰ,Ⅱ).

结果分离并鉴定了2个化合物：6-羧甲基-5，7，4'-三羟基黄酮和4，8-N-[2'-D-羟基-十六烷酰基]-1-O-D-吡喃葡萄糖基-4，8-二烯-十八鞘氨醇。

Sphingosine kinase is a key enzyme catalyzing the formation of SIP and also functions as an important signal molecule.

鞘氨醇激酶是S1P合成的关键酶，目前被证明是一重要的信号分子。

The total syntheses of sphingosine , ceramide and glycosphingolipid were reviewed with emphasis on the recent progresses.

综述了神经鞘氨醇、神经酰胺及鞘糖脂全合成研究的基本概况，重点评述了其最近的研究进展情

The roles of the VEGF receptor, KDR, and sphingosine kinase in the interactions between HGCC and HVEC were studied.

本研究还要研究VEGF受体KDR和鞘氨醇激酶是否参与HGCC和HVEC之间的相互作用。

FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Deelopment of Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

FTY720，一种合成的鞘氨醇1磷酸盐类似物，可抑制低密度脂蛋白受体缺陷鼠动脉粥样硬化的发展

Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase.

嗜热菌杀酵母素是一种有效的鞘氨醇生物合成抑制剂，能阻止合成途径中第一个酶——丝氨酸软脂酰转移酶。

Objective To construct the eukaryotic expression vectors containing the coding region of human full length sphingosine 1- phosphate receptor type Ⅰ（S1P1） gene with hemagglutinin and/or EGFP tag, and to detect its expression in HEK293 ceils.

目的构建含人Ⅰ型1-磷酸鞘氨醇受体-全长cDNA序列及HA和／或EGFP标签的真核表达载体，并观察其在HEK293细胞上的表达。

In our islet transplantation program nonhuman primates with STZ-induced diabetes received transplants under chronic immunosuppression including calcineurin inhibitors, drugs in the rapamycin class affecting growth factor-induced cell proliferation, and the sphingosine 1-phosphate receptor antagonist FTY720. Four animals developed renal failure and had to be sacrificed, most likely caused by cyclosporine.

在我们应用STZ诱导的糖尿病的灵长类动物性胰岛细胞移植的病例长期应用的免疫抑制剂包括：钙神经素拮抗剂，雷帕霉素和神经鞘氨醇1－磷酸盐FTY720.4个动物死于肾功能衰竭，这很可能是由于环孢素引起的。

Background— Numerous in itro studies suggest that sphingosine 1-phosphate (S1P), a bioactie lysosphingolipid associated with high-density lipoproteins, accounts at least partly for the potent antiinflammatory properties of high-density lipoprotein and, thereby, contributes to the antiatherogenic potential attributed to high-density lipoproteins.

背景——众多的活体研究表明鞘氨醇1-磷酸盐作为一种与高密度脂蛋白相关的生物活性溶血磷脂，至少是高密度脂蛋白有力抗炎特质的部分原因，从而促成高密度脂蛋白的抗动脉粥样硬化潜能。

These small molecules include FTY720, a sphingosine phosphate-receptor modulator, FK778, an inhibitor of pyrimidine synthesis, CP-690550, a JAK3 inhibitor, and AEB-071, a protein kinase C inhibitor.

这些小分子包括FTY720，一种神经鞘氨醇磷酸盐受体调节剂；FK778，一种嘧啶合成抑制剂；CP-690550，一种JAK3抑制剂及AEB-071，一种蛋白激酶C抑制剂。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。