鞘氨醇

SIP, which play important roles in diverse biological processes such as cell proliferation, migration and survival, is produced by metabolism of the membrane phospholipid sphingomyelin.

鞘氨醇-1-磷酸盐(S1P)是质膜鞘磷脂的代谢产物，也是重要的生物活性物质，可调节细胞的增殖、迁移、分化、死亡等。

Sphingomyelin is a kind of lipid, residing in the nature food and having latent function of inhibiting cancer. Sphingomyelin is metabolismed to ceramide and sphingosiine in the colon.

鞘磷脂是存在于天然食物中的一种具有潜在抑癌作用的脂类，在结肠内被代谢为神经酰胺和鞘氨醇。

Sphingomyelin had no inhibition to human colon cancer cells(HT-29) in vitro, so ceramide and sphingosine, the product of metabolism of sphingomyelin, was thought of having the anticancer effect.

体外实验未发现鞘磷脂对人结肠癌细胞（HT-29）有抑制作用，因此认为鞘磷脂是通过其代谢产物神经酰胺和鞘氨醇发挥抑癌作用的。

As the precursor of sphingolipids, sphingosine is one of important constituents of cell membranes.

鞘氨醇是生物体内合成鞘脂的母体化合物，是生物膜中的重要组分之一。

An improved liquid chromatographic method for the determination of sphingosine andsphinganin in human urine was developed.

建立了一种检测人尿中神经鞘氨醇和二氢神经鞘氨醇的高效液相色谱方法。

An improved liquid chromatographic method for the determination of sphingosine and sphinganine in human urine was developed.

建立了一种检测人尿中神经鞘氨醇和二氢神经鞘氨醇的高效液相色谱方法。

Researchs suggested that ceramide and sphingosine could inhibit mitosis and DNA synthesis of cancer cells, promote apop

细胞水平研究发现神经酰胺和鞘氨醇能抑制结肠癌细胞有丝分裂和DNA合成，促进细胞凋亡，影响Fas、Bcl-2、Bcl-10、bax和P53等凋亡相关蛋白的表达，即神经酰胺和鞘氨醇能通过抑制结肠癌细胞生长、促进细胞凋亡发挥抑癌作用。

An inactivation of DaCER by insertional mutagenesis caused a decrease inthe levels of sphingosine and dihydrosphingosine, especially the C_(16) sphingosine.

由转座子插入造成的DaCER功能的失活导致果蝇体内鞘氨醇和二氢鞘氨醇的水平下降，特别是C_(16)鞘氨醇的水平显著减少。

The cerebrosides and the gangliosides can also be classed as glycolipids because of the presence of carbohydrate, and the sphingomyelins and the glycolipids can be classed as sphingolipids because of the presence of sphingosine.

脑苷脂类和神经节苷脂因为存在碳水化合物可被划分为糖脂。而神经鞘磷脂和糖脂可被划分为神经鞘脂类，因为存在神经鞘氨醇。

Sphingosine 1-phosphate (S1P),which can be impacted by different growth factors through sphingosine kinase,is a bioactive lipid produced by metabolism of sphingolipid with various biological responses.

体内1-磷酸鞘氨醇（sphingosine 1-phosphase，S1P）主要来源于细胞膜鞘磷脂的分解代谢，参与S1P生物合成调节的关键限速酶为鞘氨醇激酶（sphingosine kinase，SphK）［1］。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。