靶

PIAS proteins play roles mainly through two mechanisms: acting as SUMO E3 ligases to promote modifications of some transcriptional factors and cofactors, especially sumoylation, and to regulate their transcriptional activation; acting as structural proteins to offer platforms for protein-protein interactions and to promote the abstraction and recruitment of other regulators in the cellular signal pathway complexes or gene transcriptional complexes, companied by the subnuclear location of target proteins.

PIAS蛋白的调控机制主要有两种：一种是通过其自身所具有的SUMO(small ubiquitin-related modifiers)E3连接酶活性，促进对一些转录因子、转录辅因子的化学修饰，尤其是SUMO化修饰，从而调控它们的转录活性；另一种是作为构架蛋白，为蛋白质之间的相互作用提供平台，促进细胞信号通路复合物或基因转录复合物中其它调节蛋白的去除和募集，并涉及到靶蛋白的亚核定位。

An electrostatic deflection-type camera tube has the following advantages: The small electron beam spots over the entire the scanned area provide uniform and high resolution picture, normal beam landing performance and deflection linearity are also excellent.

磁聚焦静电偏转和静电聚焦静电偏转型摄像管具有图像失真小，分辨率高且均匀，电子束易于垂直上靶，阴影小等优点，所以受到人们的重视。但图案偏转电极的形状复杂，非对称场的计算较困难。

On the basis of Movable Cellular Automata,the 2D numerical simulation of tungsten alloy armour piercer piercing armour target is done.

用可移动元胞自动机数值模拟方法，对钨合金(93W)穿甲弹侵彻装甲钢靶板进行二维数值模拟。

Results: Local high temperatures(＞70℃)were observed in pig's kidney, liver in vivo. The pathologic changes of target tissues after FEP were necrosis, liquidizatin and fibrosis.

结果：FEP可在活体猪肾、肝等组织内形成一大于70℃的局限性高温区，FEP后靶组织的病理过程为坏死、液化、纤维化。

We found that after TTT treatment, the strong reaction can cause the whole layer of retinal cell necrosis; pigmental epithelial and brush's membrane is destroyed.

最近的研究表明〓，低温的激光热疗法可以摧毁靶细胞引起细胞凋亡而不是意外的细胞死亡。

Aim According to the targets of 5-HT transporter and 5-HT2A receptor, a series of N -indolalkyl piperidine derivatives and their analogues were synthesized and tested for their biological activities.

摘要摘 要：目的以5-羟色胺转运体和5-HT2A受体为靶点，设计合成 N -吲哚烷基哌啶类化合物及其类似物，研究它们的体内外生物活性。

In the process of solving this problem, we established a mathematical model of graphics coordinate transformation, using the least square method to determine the target on the properties of the geometric center of the image in the camera image plane coordinates.

在处理这个问题的过程中偶们建立了图形坐标变换的数学模型，采用最小二乘法来确定靶标上物的几何中心在相机像平面的像坐标。

In the process of solving this problem we established a mathematical model of graphics coordinate transformation, using the least square method to determine the target on the properties of the geometric center of the camera image plane of the image coordinates.

在解决这个问题的过程中我们建立了图形坐标变换的数学模型，采用最小二乘法来确定靶标上物的几何中心在相机像平面的像坐标。

It binds to and actives a receptor protein kinase in the plasma membrane of target cells.

它结合到并活化靶细胞质膜上的受体蛋白激酶。

These results suggested that phosphatidylcholine probably was the plasma membrane target for Fengycins.

这些结果说明卵磷脂很可能是Fengycins在膜上的作用靶标。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。