靶

Results:The results showed that all of four mdr1-shRNA expression vector can significantly knockdown the expression of p-glycoprotein as compared with control vector,moreover,the vector targeting 508-526 sites of MDR1 gene is the best one.

结果：与对照载体相比，构建的4个MDR1-shRNA质粒载体均能有效下调MDR1的表达，P-糖蛋白的功能也明显降低，其中508-526靶位点的shRNA作用效果最好。

From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.

从在不同的人类癌症中检测到到它们在恶性转化，侵袭，转移中关键作用的实证， SIBLINGs 有作为诊断和预后的工具蛋白及作为新的治疗靶点蛋白的潜能。

The spinal cord, report Gaillard et al.1 in the current issue. Although the grafting of tissue to the brain has been explored as a strategy forrepairing the injured nervous system for over 100 years2, the current paper1 demonstrates a remarkable and complex set of long-distance,topographically appropriate axonal projections to a variety of targets distributed throughout the nervous system.

Gaillard等在当前的杂志中报告了放置入损伤的成年小鼠的运动皮质的胚胎皮层的移植物，令人震惊的是，它恢复了投射向远到脊髓的靶区的排列。

The occurrence and development of lung cancer was a complex multi-factorial multi-step biological process,and apoptosis imbalance was closely related to it.puma was a new member of the apoptosis-related genes that was initially identified in 2001,and was the downstream garget gene of p53,and through p53-dependent and non-dependent pathway to promote apoptosis.

肺癌的发生发展是一多因子、多步骤的复杂生物学过程，与凋亡失衡有着密切的关系。puma是2001年新发现的凋亡相关基因领域新成员之一，是p53的下游靶基因，可通过p53依赖和p53非依赖途径促进细胞凋亡，其介导的凋亡机制在肿瘤包括肺癌发展的多阶段中都起到重要的作用。

When meteorite hit the Earth surface, it created shockwave to transfer the kinetic energy to the Earth surface. When the speed of meteorite strike reached 10 km/second, the pressure of shockwave can reach several millions bar to compress the target terrane to produce heat, the effect of impact deformation caused by it is several scales stronger than rock intensity, the granite would melt down once the pressure of shockwave reached about 500 thousands bar, the granite would gasify (solid became liquid and meanwhile further became gaseity) once reaching over 600 thousand bar.

当陨石撞击地表时产生冲击波把陨石的动能传给地表，在陨击速度达到10公里/秒时冲击波的压力可达到数百万巴并压缩靶点岩层物质产生热，它产生的冲击变形效应比岩石强度大几个量级，冲击波压力约50万巴时花岗岩就熔化，大于60万巴时花岗岩就气化（在固态转为液态同时进一步转为气态）。

Prepare 131I-labbelled anti-CD20 monoclonal antibody using lodogen iodine labelling;(2)Measure the immunity activation of labbelled antibody by means of both cell combine analysis and LDH cytotoxicity detection kit;(3)Evaluate the injury rate of tumor exposed to 131I-chimeric anti-CD20 monoclonal antibody in vitro. The MTT method and the experiment of cell growth control are used;(4)Record the apotosis of Daudi cell using gelose electrophoresis;(5)Learn the inhibition effect of radioactive medication on the marrow. Radiohnmunoimages are taken on various intervals after injection of the labeled antibodies to the nude mice. The distribution of radioactive medication, I31l-labeled antibodies, in the marrow tissue indicates the inhibition effect. Here a B cell non-hodgkin lymphoma model in nude mice is established by us;(6)28-day observation are done in 3 groups of nude mice model.

(1) 用lodogen标记法制备131I-国产人鼠嵌合抗CD20单抗；(2)采用细胞结合分析法和乳酸脱氢酶法细胞杀伤性实验测定131I标记后国产人鼠嵌合抗CD20单抗与靶细胞的免疫活和利结合能力；(3) MTT法和细胞生长抑制实验测定131I-国产人鼠嵌合抗CD20单抗的体外杀瘤活性；(4)用琼脂糖凝胶电泳法研究131I-国产人鼠嵌合抗CD20单抗致Daudi细胞凋亡；(5)建立荷人B细胞淋巴瘤移植瘤裸鼠模型，应用γ计数法检测注射到荷瘤裸鼠体内的131I-国产人鼠嵌合抗CD20单抗的组织分布情况，明确其靶向性；(6)将荷瘤裸鼠分3组进行放射免疫治疗，分别为阴性对照组、131I-国产人鼠嵌合抗CD20单抗组、国产人鼠嵌合抗CD20单抗组。

Gena has successfully developed a quick molecular diagnostic system through which may simultaneously identify and differentiate kinds of different subtypes of influenza A viruses including H5N1 which highly makes illness.

我们开发出了一个可同时检测流感病毒多种亚型，包括高致病的 H5N1型的快速分子诊断系统，在一个管内采用多重逆转录 RT-PCR 法扩增可能潜在的流感病毒基因组的多个特异靶点， RT-PCR 产物可用 xMAP 技术检测和鉴别。

An inverse femtobarn at the LHC pushes the discovery range up to 800 GeV.

而LHC的1个逆飞靶会将探寻范围推高至800GeV。

Half of the shallow oxide potential in the southern half of the project. The 2004 drilling program is focused on infill and extension drilling of several targets in the Fortitude area to the north and the Glory Hole and Minnie area to the south.

Phoenix露天矿的南墙上层的潜力最大。2004年的钻探计划重点是在北面的Fortitude区和南面的Glory Hole and Minnie的几个靶区布置加密钻探和延伸钻探。

Glycans on the glycoprotein are the target molecules, which are recognized and bound by cells.

病毒糖蛋白上的糖链是机体细胞识别、结合的靶分子，并且具有对糖蛋白结构调节的特性。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。