靶

Sorafenib attacks cancer with a targeted double-barreled approach.

Sorafenib以双枪筒对准靶的的方式攻击癌变。

CSTZ is putative to regulate down-stream gene expression and improve the salt tolerance of cotton.

推测CSTZ可以调控耐盐靶基因的表达，提高棉花的耐盐性。

Though both Res and troglitazone can activate expression of PPAR-γ, they have different effect on down-stream target. It may have relation with complex structure of PPARs.

虽然Res和troglitazone都能激活PPAR-γ的表达，但是对PPAR-γ的下游靶点产生的生理作用并不完全一致，这可能与PPARs的结构复杂性有关。

We purified the target protein under natural conditions by MCAC through Ni-NTA resin. The purity of this fusion PH domain of IRS-1 was up to 98％. We paned out the oligopeptides that can bind to this target protein from a phage displayed random duodecimal peptide library. The identities of peptide sequences of positive clones were analyzed.

因此，我们利用融合表达载体pRSET在T7启动子的调控下表达出氨基端带六个连续组氨酸标签的IRS-1的PH结构域，利用Ni-NTA介质在非变性条件下对目的蛋白进行了金属螯合亲和层析纯化，获得了纯度达98％以上的PH结构域融和蛋白，以此为靶分子，从噬菌体展示随机12肽库中筛选出能够与其相结合的短肽，并分析了阳性克隆的序列一致性。

Results: The lyophilized human dura mater was used to repair dural defects in 229 patients.

用于血管内栓塞靶血管28例，可明显减少或闭塞颅内肿瘤的血供。

Our findings provided the first evidence that abnormal expression of GAT1 could result in dysgenesis, and indicated that GAT1 might be therapeutically targeted for contraception or dysgenesis treatment.

我们的发现首次证实了GAT1的不正常表达可以导致生殖障碍，并提示了GAT1可能可以用于避孕或治疗生殖障碍的靶点。

This may eventually cause problems with patient access to these new therapies, the editorial suggests. All of the targeted therapies available to date are added onto conventional treatment, thus adding costs to the healthcare system."When the goal is to improve the chance for a cure, these new treatments seem to be well worth the expenditure," comments editorialist Hyman Muss, MD, from the Vermont Cancer Center, in Burlington."However, when the goal is to improve the quality of life or delay the time to progression by several months, as it is with many treatments for metastatic breast cancer, it is less clear whether the health system can and should bear these expenses."

当病患最终接触到这些新疗法时可能会发生问题，主编表示，目前为止，这些新的标靶疗法都是加在传统疗法之上，这对医疗系统造成负担；布灵顿Vermont 癌症中心Hyman Muss医师表示，当目标放在治癒时，这些新疗法是值得研究的，然而，当目标放在改善生活质量与减缓疾病进程时，仍有许多其它疗法可以选择，这些新药物应用在这种情形下的角色仍不清楚，且应该考虑医疗系统是否能够或是是否需要负担这些费用。

We used XRD, EDS and other methods to study different samples.

并采用X射线衍射仪、场发射扫描电子显微镜等方法对不同烧结温度的羟基磷灰石靶材进行检测研究。

The cytotoxicity to K562 targets is about 86% at 20:1 of effector: target ratio.

在效靶比20：1时，NKT细胞对K562细胞杀伤率约为86%。

Success to obtained well-distributed diffusion for iodinated oil in target, as well as delayed its retention, increased adjustable and effectuation for its internal radiation.

成功获得〓I-碘化油在靶区内均匀弥散、延长滞留和辐射剂量的可监控措施，增加了〓I-碘化油介入内放疗的可控性和有效性。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。