靶

This paper describes the basic principle of velocity pursuit guidance law and body pursuit guidance law of trajectory correction projectiles , researches the terminal correction trajectory and miss distance under pursuit guidance laws by 6—DOF trajectory simulation program, researches the orbit of laser detector ray axis and ground projection area of laser detector spatial viewpoint.

文中对速度追踪制导律和弹体追踪制导律的工作原理进行了研究，利用六自由度弹道仿真程序对弹道修正弹两种追踪方式下的末段修正弹道和脱靶量进行了对比计算，研究了两种追踪方式下激光探测器光轴的轨迹及激光探测器空间视场在地面投影区域的变化；弹体追踪方式命中精度虽然较低，但由于工程实现简单、成本低，仍有其工程使用价值。

Fungi′s resistance to azole drug is the result of a variety of complex factors,but main reason is the increase expression of resistance genes and target enzyme.

真菌对唑类药物耐药性的产生是多种复杂因素作用的结果，但主要是由于某些靶酶及耐药基因表达的增加造成的。

:To study the relation between Fluconazole -resistance mechanism of Candida albicans with mutation in ERG11 gene, and determine the mechanism of drug-resistance to azole in Candida albicans.

摘要探讨白假丝酵母菌靶酶编码基因(ERG11)突变与氟康唑耐药性的关系，以分析白假丝酵母菌对唑类药物耐药机制。

The studies presented here provided the antifungal lead compounds. Because the affinity of the lead molecules for CYP51 was mainly attributed to their nonbonding interaction with the apoprotein, which was different from the azole antifungal agents.

先导分子通过与靶酶活性腔氨基酸残基的非共价键结合产生抗真菌作用，避免与血红素辅基Fe原子发生配位结合，为一类具有新作用机理的非氮唑类抗真菌先导化合物。

In comparison with the experimental data measured using the ballistic pendulum method, the present calculation method is superior to Pirri's original model.

利用这套实验装置，得到了激光与各种金属靶之间相互作用的时间和空间分辨光谱。

The primary principle of micro-impulse measurement using laser interferometry is described, and impulse can obtained by measuring tiny vibration of ballistic pendulum.

对激光干涉仪测量微冲量的原理进行了初步研究，将激光与靶材相互作用产生的微冲量转化为冲击摆的微幅振动，通过激光干涉仪辨识此振动以获得冲量。

Benzene barbitone is with medicine before art sodium 0.1, east Lang Dang alkaline 0.03mg/kg, complete hemp is revulsive use Mi Zun phenol of third of stable, different, fragrance too; of bromic ammonium of library of the Buddhist nun, dimension is maintained use static suck compound, target of bromic ammonium of library of different third phenol, dimension accuses to be defeated note, complementary aether of fluorine suction other.

术前用药为苯巴比妥钠0.1、东莨菪碱0.03mg/kg，全麻诱导采用咪唑安宁、异丙酚、芬太尼、维库溴铵；维持采用静吸复合，异丙酚、维库溴铵靶控输注、辅吸异氟醚。

The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

Giving up smoking group restore a little, the expression of long - term group are less than the short - term group, the difference may be contribute to the expressive period of c - fos.

长期吸烟后，C－fos表达降低而bax蛋白表达仍强烈，提示吸烟引起脑缺血损伤后，1＊＆首先转录翻译作为"第三信使"，又调控其它靶基因和迟发基因的表达人ax可能是其调控的基因之一，发挥其促凋亡作用促使神经细胞死亡。

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。