靶

As an amine and organic cation, agmatine also has much more targets in vivo like the NMDA receptor.

它作为一种阳离子胺类物质，除了咪唑啉受体外，在生物体内还存在多个作用靶点，NMDA受体是其中最重要的作用靶点之一。

These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

这些分子作为潜在的KARI抑制剂为基于KARI的农药分子设计提供了有利指导；对部分小分子进行了合成，在除草活性初筛的近三十个化合物中，个别化合物表现出较好的除草活性，其中一个化合物wb1596对油菜和稗草具有较高的生长抑制率，并通过E.coli KARI酶活性抑制试验验证了其KARI酶的作用靶标，此化合物可以作为KARI一个有苗头的抑制剂为后续工作奠定了基础；对发现的有苗头的KARI抑制剂进行了结构修饰和优化，合成了一系列脒类化合物并确证了它们的结构，改造后的化合物与原抑制剂相比大多除草活性相当或更佳，从而表明我们基于靶标结构的分子设计的合理可靠性；对所合成一系列脒类化合物进行了分子对接和三维定量构效关系研究。

Objective To observe the inhibitory effect of 1, 2, 6-Tri-O-galloyl-β-D-glucopyranose from Balanophora japonica Makino on human immunodeficiency virus entry into the host cells and explore the mechanisms.

目的 检测来源于蛇菰科植物日本蛇菰中的单体化合物三没食子酰吡喃葡萄糖抑制HIV与靶细胞融合的活性，并探讨其作用靶点。

For the theory, method and technique of 3D color information collected, the method for obtaining 3D space coordinate and color information of object with active illuminated multi-channel synchro scanning is presented, and the theory and method of 3D sensor and color sensor of calibration, which is the calibration techniques of BP neural network and linear partition and the method of integrating them, is also studied. A filament calibration target for 3D color system is designed and made. And the calibration of multiple sensors and the matching of 3D space coordinate information and color information, and the automatic matching of multiple sensors are realized with cameral calibration technique presented and filament calibration target designed.

在三维彩色信息获取的理论、方法、技术方面，提出采用主动照明的多通道同步扫描方法获取被测物体三维空间坐标和彩色信息，以BP神经网络、线性分区及其组合标定技术研究了三维传感器和彩色传感器标定理论和方法，设计并研制了用于三维彩色系统的细丝标定靶，并利用所提出的摄像机标定方法和细丝标定靶实现了多个传感器的标定、物体三维空间坐标信息与彩色信息的匹配及多传感器数据的自动匹配。

Important advance was made to Celastrus and ceangulin V after 20 years studies, but the target of Celangulin V was not verified and the metabolic dynamic of Celangulin V in organism was not touched because of the technique difficulty in testing and analysis of trace Celangulin V in organism. It will solve the difficulty that establishing the immunoassay of Celangulin V. The immunoassay of Celangulin V including the synthesis of artificial antigen, the preparation of antiserum, the immunoanalysis location of Celangulin V and the quantitative immunoassay of Celangulin V were studied systematicly in this paper.

苦皮藤素V是从卫矛科植物苦皮藤中分离出的一种具有杀虫活性的天然产物，可能作用于一类新的作用靶标。20多年对苦皮藤及苦皮藤素V的研究已取得了重要进展，但迄今还没有证实苦皮藤素V的作用靶标，对苦皮藤素V在生物体内的药代动力学研究也尚未涉及，这些方面的研究因为对痕量苦皮藤素V在生物体内分析、检测存在技术方法上的困难而受到限制，建立苦皮藤素V的免疫分析技术则可解决这些问题。

Important advance was made to Celastrus and ceangulin V after 20 years studies, but the target of Celangulin V was not verified and the metabolic dynamic of Celangulin V in organism was not touched because of the technique difficulty in testing and analysis of trace Celangulin V in organism. It will solve the difficulty that establishing the immunoassay of Celangulin V. The immunoassay of Celangulin V including the synthesis of artificial antigen, the preparation of antiserum, the immunoanalysis location of Celangulin V and the quantitative immunoassay of C'elangulin V were studied systematicly in this paper.

苦皮藤素Ⅴ是从卫矛科植物苦皮藤中分离出的一种具有杀虫活性的天然产物，可能作用于一类新的作用靶标。20多年对苦皮藤及苦皮藤素Ⅴ的研究已取得了重要进展，但迄今还没有证实苦皮藤素Ⅴ的作用靶标，对苦皮藤素Ⅴ在生物体内的药代动力学研究也尚未涉及，这些方面的研究因为对痕量苦皮藤素Ⅴ在生物体内分析、检测存在技术方法上的困难而受到限制，建立苦皮藤素Ⅴ的免疫分析技术则可解决这些问题。

Mathematical model was set up,on the basis of dynamics formulation,normal expanse of the target interface ,and supposed concrete medium was constringent material.

根据弹体动力学基本方程和假定混凝土为可压缩材料，基于弹靶接触表面处靶体材料的法向膨胀性，对跳弹现象进行理论分析，在合理假设的前提下，建立了跳弹现象的数学模型； 2）针对该模型编制计算机程序，在给定初始入射速度、入射角后可以判断出能否产生跳弹现象，输出产生跳弹现象时所对应的初始侵彻条件，并通过穷举法得出跳弹临界相图，对于斜侵入情况，能计算出弹体在不同侵彻阶段下的运行时间并能绘制出侵彻轨迹，结合现有的试验数据，进行对比分析，二者符合良好，证实了理论分析模型的合理性； 3）开展了跳弹现象的数值模拟研究。

ThenWestern blotting were applied to detect nuclear EGFR and cytoplastic EGFR in Caski cellswhich showed hight level expression of EGFR after radiation.

第四部分辐射对宫颈癌细胞EGFR核转运的影响EGFR家族成员直接转运入核调节靶蛋白和靶基因的表达和活性是新近发现的EGFR家族传递信号的新途径。

A detector array target of laser distant-field detect system is designed, and two key factors are analyzed. To determine the size of the array target, the laser diffract effect and the influence of atmospheric turbulence are discussed, three factors that influence the resolution of the array target are analyzed. Three factors are the dimension of laser speckle resulted by atmospheric turbulence, space sampling frequency based on sampling theory and the loss of the frequency spectrum function of the array detector.

设计了一种激光远场直接探测系统，对系统中的两个关键问题进行了讨论，一、在探测器阵列靶板尺寸的确定问题上讨论了激光的衍射效应和大气湍流的影响；二、在探测器阵列靶板分辨率的确定问题上讨论了激光的衍射效应和大气湍流的影响；对第二问题讨论了对其有影响的三个方面：大气湍流引起激光碎斑尺寸，由采样定理决定的空间采样率，由阵列探测器的频谱函数引起的损失。

The bone dosimetric values are influenced by the parameters of skeleton mass.

鉴于骨骼组织不同部位的辐射敏感性存在差异［2］，特别是已确认骨髓的造血干细胞和衬在骨表面上的成骨细胞是骨骼中致癌危险的靶细胞，因而ICRP30号出版物［3］详细介绍了估算骨骼靶器官的吸收剂量的骨剂量学模型，使骨剂量的计算趋向精确。1995年，ICRP又专门编著了用于辐射防护的骨骼解剖和生理参数的70号出版

They go to town. Would you just ask them?

他们在城里你能问他们吗？

Ossein pretreated for a2 weeks period exhibited the maximum% yield incase of bone gelatin, while the yield from intact skin was higher than that realized incase of de-scaled skin.

预处理时间达2星期的骨胶原表现出最高的骨明胶百分产量，然而从未处理鱼皮中得到的产率比去鳞的鱼皮得到的要高。