靶

Our results showed that 1, 8-Naphthyl imide could improve the properties of natural oligonucleotide in resisting nuclease and binding the targeted sequence by covalently linkage at the end of oligonucleotide. Moreover, our results also showed that the antigene oligonucleotide could specifically cleave the targeted double DNA sequence by modification of naphthyl imide at the 3'end of oligonucleotide.

体外结果表明萘二酰亚胺对寡核苷酸的共价修饰可以提高天然寡核苷酸抗核酸酶降解能力，提高寡核苷酸与靶序列结合的稳定性以及使寡核苷酸具有选择性结合和切断靶DNA的功能。

Methods: TOCA was labeled with (superscript 99m)Tc using HYNIC as bifunctional chelator, EDDA and trieine as coligand. The nude mice bearing human small cell lung cancer underwent static whole body planar imaging after the injection of (superscript 99m)Tc-HYNIC-TOCA or (superscript 99m)Tc-P829. ROIs were drawn and the radioactivity ratios of target to non-target were calculated in every planar imaging. The dynamic biodistribution study was operated in Kunming mice and the percent uptake ratios of two imaging agents in different tissue at different time were measured.

以HYNIC为双功能螯合剂(bifunctional chelator， BFC)，乙二胺－N，N'-二乙酸和三甲基甘氨酸为协同配体进行TO-CA的(上标 99m)Tc标记；以(上标 99m)Tc-HYNIC-TOCA和(上标 99m)Tc-P829为显像剂，对荷人类小细胞肺癌裸鼠进行显像，通过感兴趣区技术进行半定量分析，计算并比较两种显像剂的靶/非靶比值；在昆明鼠体内进行动态生物学分布实验，测定并比较不同时点两种显像剂在各脏器的克组织百分摄取率。

Three RNAi target sites (named as Abil1, Abil2, Abil3) targeting the E3B1 (NCBI: NM-024397), an identified target sites and positive control GAPDH-A were selected. The pGenesil-1 eukaryotic expression vectors with the neoR mark and GFP green fluorescent mark were selected to construct E3B1 RNAi plasmid. The effect of RNAi targeting various sites on E3B1 genes expression was evaluated by testing the transfection efficiency with fluorescence microscope and western blot. The most effective siRNA in inhibiting E3B1 genes were screened. The most effective siRNA in inhibiting E3B1 genes screened and used to transfect the neuronal cells. After that, the inhibitor of axon growth was added and the axon growth was observed. Result: The siRNA expressing plasmids targeting the E3B1 were constructed successfully.

选择针对E3B1(NCBI： NM-024397)RNAi的3个靶位点Abil1、Abil2、Abil3和1个不针对任何mRNA的RNAi靶位点以及甘油醛－3-磷酸脱氢酶，用带有neoR选择标志和GFP绿色荧光标志的真核表达载体pGenesil-1构建E3B1 RNAi质粒，分别转染培养的神经元，在荧光显微镜下观测转染率，经G418筛选得到单一的转染细胞，并用Western blot法检测各转染组神经元E3B1蛋白的表达情况，选出具有最佳抑制效应的siRNA转染神经元，加入轴突生长抑制物，观测轴突生长情况。

And unlike in the current iteration of the NIF, which is capable of blasting one pellet every few hours, targets will cycle through the chamber with the speed of a Gatling gun.

并且和NIF几个小时轰击一个靶丸不同，靶丸在LIFE的反应室里循环的速度就像一架格林机关枪。

Testing results showed that in a sputtering cycle the sputtering time for Cu/Ga target has greatest effect on the final element distributi

实验中发现，在一个溅射周期中，Cu/Ga合金靶溅射时间对最后成分影响最大，其次是In靶溅射时间，非溅射时间的长短对成分也有影响。

Testing results showed that in a sputtering cycle the sputtering time for Cu/Ga target has greatest effect on the final element distribution and that for In target is the next.

通过可变占空比的电源控制器实现对Cu/Ga合金靶以及In靶溅射时间的控制，进而实现对最后元素配比的控制。

The average depth of erosion on gritstone for cavitation water jets is 2 times as much as common water jets, and its mass erosion is 7 times as much as common water jets, and its diameter of erosion is 2.3 times as much as common water jets.

对于含有空泡的磨料射流，围压增加空化噪音减少，泵压增加空化噪音增加；有效靶距直径比增加，对花岗岩的冲蚀深度与冲蚀质量存在一最优有效靶距直径比；在最佳冲蚀时间下，较纯水空化射流工作效率提高2倍。

KIR bind corresponding HLA-Ⅰmay hame four results followed:1、When inhibitory KIR bind HLA-Ⅰand there has no activatory KIR bind it,cell isn\'t dissolve because inhibitory signal access was done;2、When activatory KIR bind corresponding HLA-Ⅰand there has no inhibitory KIR bind it,form activate signal,lead cell dissolve.3、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when activatory signal play the main role,NK cell still actived,lead target cell dissolve.4、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when inhibitory signal play the main role,or both signal access don\'t play,NK cell do not make effect.this is NK cell recognice nomal tissue.

与活化型KIR受体相比，抑制型KIR受体与HLA-Ⅰ类抗原结合的亲和性更强，当抑制型和活化型KIR受体识别和结合同一HLA-Ⅰ类抗原分子时，以抑制作用为主。KIR与相应HLA-Ⅰ结合后可能产生以下4种情况：①当抑制型KIR与HLA-Ⅰ结合而无活化型KIR与HLA-Ⅰ相互作用时，因抑制信号通路启动而不产生细胞溶解；②当活化型KIR与靶细胞表面的相应HLA-Ⅰ结合同时无抑制型KIR与HLA-Ⅰ的相互作用时，形成刺激信号通路，导致靶细胞溶解。

It was applied to the case study of non-target site glyphosate resistance in horseweed; and the data was mined to discover resistance target gene.

它被应用到加拿大乍蓬中非靶位点草甘膦抗性的案例研究中；数据被挖掘以发现抗性靶基因。

Abstract］ Background and purpose:The imaging of the skull base is challenging in nasopharyngeal carcinoma, through studying visualization and the appearance of foramen ovale,foramen rotundum,foramen spinosum,hypoglossal canal and nerve which can be identified on registration of CT and MRI for nasopharyngeal carcinoma, in order to define the target volume of nasopharyngeal carcinoma in radiotherapy planning.

为明确MRI对鼻咽癌颅底区域靶区显示的情况，分析无颅神经侵犯鼻咽癌患者的CT、MRI，比较圆孔、卵圆孔、棘孔、舌下神经管及舌下神经CT、MRI的显示情况和影像表现，探讨圆孔、卵圆孔及棘孔、舌下神经管及舌下神经在鼻咽癌放射治疗靶区勾画的意义。

They go to town. Would you just ask them?

他们在城里你能问他们吗？

Ossein pretreated for a2 weeks period exhibited the maximum% yield incase of bone gelatin, while the yield from intact skin was higher than that realized incase of de-scaled skin.

预处理时间达2星期的骨胶原表现出最高的骨明胶百分产量，然而从未处理鱼皮中得到的产率比去鳞的鱼皮得到的要高。