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Nicotinamide adenine dinucleotide phosphate oxidase is a major source of reactive oxygen species production in many nonphagocytic cells.

还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶是许多非吞噬细胞中反应性氧自由基产生的主要来源。

The relationship between this system and serum autoantibody levels was also studied.

采用逆转录聚合酶链反应方法检测18例活动期LN患者、16例非活动期LN患者和10名正常人PBMCs内IL-6、gp80与gp130的mRNA表达水平。

Objective: To study the expression of F1ATPase-α in non-small cell lung cancer and its clinical significance.

目的:研究人类非小细胞肺癌组织中ATP合酶F1ATPase-α的表达,并探讨其临床意义。

Selective enzymatic synthesis of drug derivatives containing carboxyl group in non-aqueous media was also developed.

论文发展了非水介质中含羧基药物衍生物的酶促选择性合成方法。

The possibility of crosslink between sodium caseinate and whey isolateand the impacts on functionality after crosslinking by transglutaminase and the application of transglutaminase on yoghurt were studied.

首先,利用SDS-PAGE电泳结合凝胶成像分析技术,比较了在非变性、加入还原剂(20mmoL/LDTT)变性和在80℃预热15min后并再加入一定量还原剂(20mmoL/LDTT)变性三种条件下转谷氨酰胺酶对2%酪蛋白和乳清蛋白之间的交联情况。

Many enzymes will not work without the presence of an additional nonprotein substance called a cofactor.

许多酶如不外加一种叫做辅助因子的非蛋白质物质就不能工作。

At last, during the incompatible interaction, chromatin condensation and marginalization in the nucleus happened, but DNA cleavage of nucleosomal and"DNA Ladder"didn't occurre.

首次利用oxyhemoglobin assay在单子叶模式植物水稻中测定了iNOS酶活性,初步明确了在Xcv与水稻细胞非亲和性互作中NO产生来源及其对过敏性反应的调控作用。

The investigation of enzyme's applications to paper industry consists of improving the drainage property of non-wood pulp and deinking of nonimpact printed papers.

纤维素酶在造纸工业中的应用研究主要包括两方面的内容:一是改善非木材纤维的滤水性能,二是促进非接触印刷纸的脱墨。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大,疗效确切的抗真菌药,如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等,该类药物主要抑制β-葡聚糖合成酶,体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性,又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在,故具有高效低毒的临床效果,是一极具前途的新型抗真菌药;以真菌细胞膜为靶点开发出Histatin类药物,虽然作用机制目前还不完全明了,但其作用不同于临床常用的多烯类和氮唑类,并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效,并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用;通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Previous studies have found the major metabolic way of clivorine in male rat liver microsomes was to form pyrrolic metabolites. The above results suggested that there is sexual difference of metabolism in rats. The major in vitro metabolic way of clivorine in guinea pig was hydrolysis.

FMO的特异性抑制剂methimazo1e可以显著地抑制〓的形成,但对〓的形成无明显的抑制作用,且〓在肝微粒体中的形成为NADPH非依赖性,上述结果提示参与〓和〓代谢的酶分别为肝微粒体中的水解酶和黄素单氧化。

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