非细胞的

AIM: To investigate the expression of extracellular matrix metalloproteinase inducer and hepatocyte growth factor in non-small-cell lung carcinoma and their relationship with lymphoid metastasis and prognosis.

目的： 研究细胞外基质蛋白酶诱导因子和肝细胞生长因子在非小细胞肺癌组织中的表达及其临床意义。

Methods Peritoneal macrophages of guinea pigs were infected in vitro by three different Leptospira strains, the virulent Leptospira interrogans serovar Lai type strain Lai, the avirulent L. interrogans serovar Lai type strain IPAV, and the nonpathogenic L. biflexa serovar Patoc type strain PatocⅠ, respectively, and heat inactivated Staphylococcus epidermidis was added 0.5, 1.5, 3 and 6 h after infection and incubated for 30 min. The effect of Leptospira on the phagocytosis of macrophage was evaluated by the inactivated Staphylococcus epidermidis phagocytosis rate and phagocytosis index. Phagocytosis and ultrastructure of peritoneal macrophages were observed by transmission electron microscopy 3 h after infection, and changes of cytoskeleton of the macrophages were observed by laser scanning confocal microscopy.

用三种不同毒力的钩体（致病性问号钩端螺旋体赖型有毒株Lai株、赖型无毒株IPAV株以及非致病性双曲钩端螺旋体Patoc型PatocⅠ株）分别感染体外培养的豚鼠腹腔巨噬细胞，并分别于感染后0.5、1.5、3和6 h加入热灭活表皮葡萄球菌孵育30 min，通过计算巨噬细胞对灭活表皮葡萄球菌的吞噬率和吞噬指数，检测钩体对巨噬细胞吞噬功能的影响；感染后3 h透射电镜观察巨噬细胞对钩体的吞噬、降解和细胞超微结构的变化；用激光共聚焦显微镜观察细胞对钩体的吞噬和巨噬细胞细胞骨架的变化。

MAPK signal transduction is correlative with human non-small cell lung cancer closely. The overactivity of P38 may play an important role in the development of human non-small cell lung cancer.

MAPK通路与非小细胞肺癌的发生、发展密切相关。P38的过度激活在非小细胞肺癌的发生、发展过程中可能起着重要的作用。

Cell elongation in the middle and upper middle stipe regions accounted for most of the stipe elongation but this was accompainied by cell divisions.

在原基体时期其快速生长区间菌柄细胞数为其他部位的四倍，其细胞生长主要在基部最为活跃，而非其边缘细胞。

METHODS: Bone marrow mononuclear cells were isolated from 5M4/M5 leukemia patients with high CD14 expression, and then divided into 3groups: adherent leukemia cells, nonadherent blasts, and total unfractioned blasts.

取5例初诊CD14高表达的M4或M5型白血病患者的骨髓标本，分离单个核细胞(bone marrow mononuclearcells，BMMNCs)，将白血病细胞分为3组：贴壁白血病细胞组、非贴壁白血病细胞组及总白血病细胞组。

MTT may be used as a new photosensitizer underlight,non-light and different light energy intensity,with no toxic effectto C6 cells under non-light and increased toxicity under increased lightenergy intensity.

在光与非光、及不同光能量密度条件下应用MTT有可能成为新一代的光敏剂，其在非光照射时对C6无细胞毒作用，其细胞毒作用随光能量密度的增加而增强。

However, fully consideration of special structure and physiological function of CRP is critical to investigate whether CRP provide protect effect or pathogenic effect in the progression of atherosclerosis. CRP is a member of pentrxins family, which consists of five identical, noncovalently associated 23-kDa protomers arranged symmetrically around a central pore with a 102 A external diameter. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. The opposite face of the pentamer is the effector face, where complement Clq binds and Fc receptors are presumed to bind. A cleft extends from the center of the protomer to the central pore of the pentamer. Both faces ofpentamer form a special bi-phase structure: one face is the ligand recognition phase, which can recognize apoptosis cells and enzyme modified low density lipoprotein in which PCh is exposed.

CRP是一种五聚体蛋白，外径为102 A，由5个相同的单体以非共价键结合，形成双面的环形结构，每个单体的配体识别位点或受体结合位点分别位于五聚体两个平面上，分别组成配体识别相和效应器相，从而构成特殊的二相性结构：一面为配体识别相，含有磷酸胆碱(phosphorycholine，PCh)结合位点，能够使CRP识别在病理条件下暴露出PCh的凋亡细胞、酶修饰低密度脂蛋白(enzyme modified low density lipoprotein，E-LDL)等。E-LDL是天然低密度脂蛋白(native Low density lipoprotein，N-LDL)在多种蛋白酶，如胰蛋白酶、神经氨酸酶、胆固醇酯酶等作用下的代谢产物，其主要特点是结构发生改变(N-LDL大小均匀，平均直径250±30 A，E-LDL大小差异极大，直径为100-2000 A)，暴露磷酸胆碱位点，能够被CRP识别；另一面为效应器相，能够与巨噬细胞、单核细胞表面受体FcγRⅡa结合，介导巨噬细胞、单核细胞识别及吞噬凋亡、坏死细胞作用。

The former formed a kind of KR cyst, while the later formed a kind of NKR cyst. All the kinetosomes, ciliary shafts and microtubules were resorbed in the former, meanwhile, the cell lost most water and cell volume decreased distinctly. In the later, only part of kinetosomes and part of microtubules were resorbed. Cell lost water slightly and volume decreased slightly.

期间，细胞吸收了全部的毛基体、纤毛杆和微管结构，伴随着细胞剧烈的失水浓缩，细胞体积显著缩小；游仆虫在形成毛基体非吸收型包囊时，细胞仅经历了部分的脱分化过程，期间，细胞仅吸收了部分的毛基体及部分微管结构，并且细胞仅发生了轻微的脱水和浓缩，细胞以折叠的形式容纳在包囊壁内。

The primary radiation reaction is marrow depression, and primary lung radiation reaction. There are 8 marrow depression cases in these groups,(degree Ⅰ: 5 cases, degree Ⅱ: 3 cases). Leukocyte and haematoblast decreased in these cases. Primary lung radiation reaction cases is 6(degree Ⅰ: 4 cases, degree II: 2 cases).

早期非小细胞肺癌的外科手术切除可以获得60%~70%的5年生存率，但是，一部分早期非小细胞肺癌患者因呼吸功能和心功能低下、糖尿病、血管系统疾病，一般状况差而不能耐受手术或术后不易康复，还有一些患者拒绝手术。

It was also found base transversion had a extremely high ocurrence frequency in the single base substitution mutants when the plasmid was replicated in FL-FEN-1〓 cell or MNNG pretreated FL-FEN-1〓 cell, while in all mutants with multiple base substitution there were at least one transversion mutation taken place.

分析还发现，在FL-FEN-1〓细胞自发突变和非定标突变含有单碱基替换突变的突变子中，碱基颠换的发生率极高，而在FL-FEN-1〓细胞自发突变和非定标突变的多碱基替换突变子中，每个突变子均至少含有一个碱基颠换突变。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷