非恶性的

PartⅡDiffusion-weighted MR Imaging of breast mass and non-mass lesionPurpose:To evaluate Diffusion-weighted MR Imaging of breast mass and non-mass lesion in lesion characterization by comparing ADCs of malignanty with benignancy.

第二部分磁共振扩散加权成像在乳腺肿块性病变和非肿块性病变中应用价值的对比研究目的：对比乳腺良、恶性病变的表观弥散系数(apparent diffusioncoefficient，ADC)，探讨DWI在乳腺肿块性病变和非肿块性病变中的诊断价值。

Materials and Methods:236 pathology-confirmed breast lesions(155 malignanty,81 benignancy) and 221 disease-free contralateral breast tissues were examined using EPI-DWIb values=0,1000 s/mm~2TR/TE=8400ms/93.8ms; FOV=30×30cm;matrix=128×128;ASSET=2,slice thickness=4mm.DCE-MR imaging was also performed for accurate location of the lesion using VIBRANT sequence.The mean ADC values of malignant and benign lesions and the disease-flee contralateral breast tissues were calculated from the ADC map for each patient.One-way analysis of variance was applied to compare the mean ADCs of malignant lesions with benign lesions and disease-flee contralateral breast tissues.The threshold ADC value for malignant lesion was determined using a receiver operating characteristic(ROC curve analysis.Each lesion was classified into two major types:mass and non-mass lesion.The diagnostic performance of DWI was compared in breast mass and non-mass lesions.Results:155 malignant and 81 benign lesions were confirmed in 236 lesions.

材料与方法：搜集术前行乳腺MR检查并经穿刺或手术病理证实的236例乳腺病变，以对侧正常乳腺腺体作为正常对照，采用横轴位的平面回波-扩散加权成像序列，TR=8400ms，TE=93.8ms，层厚=4mm，激励次数=2：视野=30×30cm，矩阵=128×128，ASSET=2，b值=0和1000s/mm~2；参考动态增强图像准确定位，测量病变区和对侧正常乳腺腺体的ADC值，应用t检验比较良、恶性病变及正常腺体ADC值的差异，采用接收者工作特征曲线(receiver operating characteristic curve，ROC)确定良恶性病变的ADC界值；根据BI-RADS MRI将乳腺病变按照形态学表现分为肿块性病变和非肿块性病变两组，比较ADC值在肿块和非肿块性病变中定性诊断的效能。

Primitive pathology is diagnosed include to be not epithelioma of road of make water of shape of tit of wellability low level (epithelioma of road of make water of shape of tit of high level of N=23), blame wellability (N=6), low the way of tit shape make water that spends malign potential is epithelial tumor (tumour of shape of N=5), tit (N=3),...

原始病理诊断包括非浸润性低级别乳头状尿路上皮癌(n=23)、非浸润性高级别乳头状尿路上皮癌(n=6)、低度恶性潜能的乳头状尿路上皮肿瘤(n=5)、乳头状瘤(n=3)、尿路上皮肿瘤(n=2)、原位癌(n=1)以及鳞形细胞癌n。。。

In order to evaluate the roles played by telomerase activity and apoptosis gene in malignant transformation of mammary atypical ductal hyperplasia, as well as the ultrastructure characteristic and regular pattern in the transformation, we investigated the expression of telom- erase genes and apoptosis related genes (p53 and bcl-2) and ultrastructure characteristic in precancerous lesion-mammary atypical ductal hy- perplasia, and compared with breast carcinoma and benign hyperplasia.

本文研究端粒酶基因、凋亡相关基因（p53、bcl-2）在乳腺癌前病变-乳腺导管非典型增生中的表达情况，探讨乳腺导管非典型增生上皮的超微结构特征，并与乳腺癌、乳腺导管单纯性增生进行对比，旨在研究端粒酶活性变化及凋亡相关基因在乳腺导管非典型增生上皮细胞癌变过程中的作用及意义，并研究乳腺导管非典型增生上皮细胞恶性转化过程中的形态结构特点及变化规律。

objective to evaluate the role of mr perfusion weighted imaging in preoperation diagnosis of meningiomas.methods mr perfusion weighted images was performed in 47 patients with meningiomas followed by conventional imaging.results the mean rcbv values of angioblastic was the highest in the parenchyma of tumor.the mean rcbv values of malignant group was the lowest.the biggest mean rcbv values among different type meningiomas was statistically significant.the biggest mean rcbv values between benign and malignant group meningiomas was statistically significant,but not in the peri-tumor edema.conclusion the rcbv values were useful in the preoperative differentiation diagnosis of different types of meningiomas.those in the peri-tumor edema were useless in the preoperative differentiation diagnosis of different types of meningiomas.

目的 探讨磁共振灌注成像技术对脑膜瘤术前分型及良恶性鉴别的临床应用价值。方法对47例脑膜瘤病人行mr灌注成像检查，对5种亚型的良性脑膜瘤的mr灌注成像进行分析，并与非典型性及恶性脑膜瘤进行比较。结果血管瘤型脑膜瘤实质部分的rcbv值均数最高，恶性组脑膜瘤的rcbv值均数最低。各亚型间瘤体实质最大rcbv值均数间差异有统计学意义(p＜0.05)，良恶性脑膜瘤实质部分最大rcbv值均数间差异有统计学意义(p＜0.05)。瘤周水肿区的rcbv值均数间差异无统计学意义(p＞0.05)。结论 rcbv值对脑膜瘤术前分型及良恶性鉴别有所帮助，而瘤周水肿区的rcbv值对脑膜瘤分型及良恶性鉴别未显示临床实用价值。

Objective We sought to investigate the clinical features as well as characteristics of the immunological forms with respect to the idiopathically head-neck non-Hodgkin's lymphoma.

恶性淋巴瘤是来自淋巴系统及网状内皮系统的非上皮性恶性肿瘤。非霍奇金淋巴瘤常发生在淋巴结内，而首发于淋巴结外的恶性淋巴瘤仅占全身恶性淋巴瘤的10%~15%，易于广泛播散。

The role of radiation therapy for these patients continues to be refined with recent advances in technology minimizing its toxicity to surrounding nonmalignant liver.

在这些中期肝癌的病人使用的放射治疗法，已经用最新的技术进行改良以减小它对周围的非恶性肝组织的毒性作用。

Nevertheless there have general positive expression of Wnt5a in cases of nonmalignant hematologic diseases.

在31例血液病标本及髓系白血病细胞株中，除ALL外，有明显的Wnt5a表达缺失或降低，而非恶性血液病例中Wnt5a表达普遍呈阳性，提示Wnt5a的表达下调可能与髓系白血病的发生有关。

Methods genomic dna was extracted from different stages of malignant transformation and tumorigenicity in inoculated athymic mouse 16hbe cells induced by cadmium chloride and methylating status of genome p16 gene promoter was observed with methylation-specific pcr and then compared with the controls.

从各组cdcl2恶性转化不同阶段及接种裸鼠成瘤的16hbe细胞中提取全基因组dna，采取甲基化特异性pcr法(methylation-specific pcr，msp)检测该基因组p16基因启动子区的甲基化状况，与非转化的16hbe对照细胞进行比较，并用去甲基化因子5-azac (5-aza-2'deoxycytidine)处理有异常甲基化的细胞。

Malignant melanoma: Malignant melanoma can occur on any area of the skin or mucosa, even in non–sun-exposed skin, as in this patient.

恶性黑素瘤：恶性黑素瘤可以出现在皮肤或粘膜的任何地方，甚至在非阳光照射部位的皮肤，正如该患者一样。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！