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静脉注射

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Rats in control group and model group received 0.9% sodium chloride solution 10 mL/kg. Rats in compound danshen dripping pills group received 0.75% compound danshen dripping pills 10 mL/kg. Rats in Xintongzhi drop pill high dose group and Xintongzhi drop pill low dose group received 3.6%, 1.8% Xintongzhi drop pill 10 mL/kg, respectively. After 7 days except control group, myocardial ischemia models were established by ranine vein of hypophysin in other four groups. The changes of lactate dehydrogenase,α-Hydroxybutyrate Dehydrogenase, creatine kinase, creatine kinase MB and ECG were recorded in each groups.

正常组和模型组予0.9%氯化钠注射液,复方丹参滴丸对照组予0.75%复方丹参滴丸水溶液,心痛治滴丸高剂量组、心痛治滴丸低剂量组分别给予3.6%、1.8%的心痛治滴丸水溶液,各组均10 mL/kg,每日1次灌胃。7日后除正常组外,其余4组均采用垂体后叶素0.5 U/kg舌下静脉注射制备大鼠急性心肌缺血模型,并检测各组乳酸脱氢酶、α-羟丁酸酶、磷酸肌酸激酶及磷酸肌酸激酶同工酶和心电图的改变。

Patients in group K received ketamine 1.0 mg/kg intravenously ratherly before the tourniquet deflation .Patients in group C received the same volume of normal saline with the same method as group K.

择期行膝关节手术患者50例,随机分为观察组和对照组,均在腰硬联合麻醉下手术。K组在止血带松气前1 min静脉注射氯胺酮1.0 mg/kg,C组未用。

a three steps sequence therapy was designed for patients suffered post dural puncture headache total 45 cases:step one,patient keep supine recumbence,and intravenous injection of ringer's solution 1000ml with intramuscular injection of tramadol 100mg was administrated. if pdph could not relieve within 24hr,the next step should be use. step two,drinking a cup of coffee three times a day for patients who were allowed to eating or intravenous injection ketamine 0.5mg/kg for patient in fasting diet.

选择椎管内麻醉后发生头痛的病例共45例,按设定的序贯疗法分别为a:去枕平卧1d,每天补液量增加1000ml平衡液,肌注曲马多100mg,无效时进入b和c;b:能进食者给予市售咖啡饮品,每天三次;c:不能进食者静脉注射氯胺酮0.5mg/kg,连用2d;以上治疗无效时进入d:行硬膜外填充自体血10ml。

A three steps sequence therapy was designed for patients suffered post dural puncture headache total 45 cases:step one,patient keep supine recumbence,and intravenous injection of Ringer's solution 1000ml with intramuscular injection of Tramadol 100mg was administrated.

选择椎管内麻醉后发生头痛的病例共45例,按设定的序贯疗法分别为A:去枕平卧1d,每天补液量增加1000ml平衡液,肌注曲马多100mg,无效时进入B和C;B:能进食者给予市售咖啡饮品,每天三次;C:不能进食者静脉注射氯胺酮0.5mg/kg,连用2d;以上治疗无效时进入D:行硬膜外填充自体血10ml。

METHODS Rats were pretreated with rutaecarpine 10 min before the experiment, and then the left main coronary artery of rat hearts was subjected to 60-min occlusion followed by 3h reperfusion.

大鼠在实验前10 min静脉注射吴茱萸次碱,然后结扎冠状动脉左前降支60 min,再灌注3 h。

Methods:Baseline intramyocardial flows in left ventricular anterior wall in 15 normal subjects and in 14 patients with coronary artery diseasewere examined by CDCFI and pulse-wave Doppler.Then Albunex(0.08ml/kg)at bolus and after 15 min interval dipyridamole(0.56mg/kg)was injected within 4 mins respectively and intramyocardial flow in the anterior wall was observed sequentially.Results:In all normal subjects and 13 patients with CAD,color flow signals could be displayed scatteredly in the anterior wall.

应用冠脉血流显像技术检测15例正常人和14例冠脉造影证实为前降支中段和近段狭窄的冠心病患者前壁心肌内血流,显示清晰二维彩色多普勒信号后,应用脉冲多普勒探测血流频谱;分别在不同时刻经静脉注射Albunex 0.08ml/kg和潘生丁0.56mg/kg后,观察前壁心肌内彩色多普勒血流信号和频谱变化。

5Min after iv, scutellarin was found in tissues with high concentration in liver, kidney, small intestine, and low level in other tissues.

静脉注射后5min,各脏器中即有分布,其中肝、肾、小肠含量较高;其他各组织的浓度较低。

RESULTS: Daily intravenous bolus applications of BDNF during the first 5 days after stroke resulted in significantly improved sensorimotor scores up to 6 weeks.

结果:卒中后在前5年内每天静脉注射BDNF团丸可获得感觉运动评分在6 周时显著改善。

The latter group was older, more likely to be African-American, and to have a history of intravenous drug abuse than those who were HCV seronegative.

与HCV血清阴性的群体相比,在HCV血清阳性的群体中,患者的年龄更大,更可能是有非洲血统的美国人,有静脉注射毒品的历史。

Viral vector mainly contain adenovirus, retrovirus,adeno-associated virus and so on, but it has potential danger of safety; it isrepeled by immune system when it is injected to organism for a greatimmunogenicity. An injection with adenovirus vector with highconcentration, it leads to serious inflammatory reaction of liver. Viralvector such as liposome and polycation are commonly used lately. But,liposome and polycation have low specificness and targetness of genetransfer tissue, have lower transfection efficiency and short period ofgene expression, for they can be phagocytized by endothelial system.

许多的载体,病毒载体和非病毒载体以前已广泛应用,病毒载体主要包括腺病毒,逆转录病毒,腺相关病毒等;但病毒载体在安全性方面存在潜在的危险;免疫原性比较强,注射到机体后很快会被机体的免疫系统排斥,当静脉注射高浓度的腺病毒载体会使肝脏发生严重的炎症反应;非病毒载体目前常用的有脂质体及多聚阳离子聚合物;但脂质体和阳离子聚合物介导基因转移缺乏组织的特异性和靶向性,转染效率较低且易被网状内皮系统吞噬,基因表达时间短;因此研制新型的非病毒载体已成为研究的热点,纳米颗粒具有小尺寸效应,表面效应,随着颗粒直径变小,比表面积将会显著增大,故具有很高的化学活性,因而纳米成为了最有应用前景的非病毒载体。

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