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Chapter 4: The binding of Rhein with human serum albumin has been studied in detail by Spectroscopic method including circular dichroism, fourier transformation infrared spectra, fluorescence spectra.

分子对接研究表明大豆苷元和刺芒柄花素的结合区域位于蛋白质的亚结构域ⅡA中,主要通过疏水作用结合,但还包括静电作用力、氢键的存在。

The dissociation constant of TCS with negatively charged phospholipid is obtained, and the mechanism of TCS/membrane interaction was also investigated. Two major forces including electrostatic and hydrophobic interaction are involved in the binding process.

我们获得了天花粉蛋白与负电磷脂的结合常数,并对天花粉蛋白与膜的结合力也进行了研究,结果表明天花粉蛋白可能以静电和疏水两种作用力与膜结合。

Five novel torsion-mirror optical actuators including double-beam thickness differential structure with single torsional axis, double flexible folded-beam structure with single torsional axis, double-beam vertical torsion comb structure with single torsion axis, four-beam differential compound-micromirror structure with double torsional axis and the combined structure of the four basis forms above, are brought forward. All of these devices could be fabricated by the same silicon micromachining process we have developed. The deformation compensation design with local enhancement for the thin torsional beam which is the key structure of these devices is also put forward to improve the reliability. The three-dimension solid model and two-dimension reduced order model of the torsion-mirror optical actuator are established and then the numerical simulations for evaluating the device characteristics of the statics, dynamics, electrostatic field, mechanical and electrostatic coupling, fluid and solid coupling are carried out to optimize the structure design. Furthermore, three optical fibre clamping structures which could be integrated monolithicly are designed and analyzed to improve the optical coupling capability. 4. Three flexible process flows combined with bulk silicon micromachining and surface silicon micromachining are brought forward to fabricate these novel single-crystal silicon or polysilicon torsion-mirror optical actuators by using the same lithography masks for both SOI wafer and regular silicon wafer. A series of important process experiments are carried out to optimize the process parameters and the process flows. Some novel and typical process phenomena which occurred during the microfabrication are analyzed and then the corresponding solutions are put forward. 5. A MEMS dynamic testing system which exploit blur image synthetic technique, stroboscopic image matching technique, stroboscopic mirau microscopic interferometry technique and microscopic laser dopper vibrometer technique is set up to measure three-dimension and six-freedom micro motions of any MEMS devices with nanometer resolution.

在对硅微机械扭转镜光致动器的光机电特性系统地理论研究的基础上提出了硅微机械扭转镜光致动器的结构设计准则。3、提出了单轴双梁厚度差分结构、单轴双柔性折叠梁结构、单轴双梁垂直扭转梳齿结构、双轴四梁差动复合微镜结构以及以上四种基本结构组合后的衍生结构等五种工艺加工技术兼容的新型的硅微机械扭转镜光致动器,对器件关键结构薄厚度、高耐疲劳扭转梁进行了局部加强的变形补偿设计,建立了器件的三维实体模型以及两维降阶模型,对提出的新结构硅微机械扭转镜光致动器进行了系统的静力学、动力学、静电场、力电耦合和流体固体耦合的建模仿真与优化设计,同时设计并分析了三种可实现单芯片集成的弹性光纤定位夹紧结构。4、提出了组合体硅微加工技术与表面硅微加工技术、兼容同一套光刻版图、可分别基于SOI 晶片和普通Si 晶片、适应于制造提出的各种新结构单晶硅和多晶硅硅微机械扭转镜光致动器的三套柔性加工工艺流程,开展了一系列重要工艺步骤的单项工艺试验,对工艺流程与工艺参数进行了优化,针对加工过程中出现的具有普遍意义的典型工艺问题进行了讨论和分析,并提出了解决方法。5、创新性地将模糊图像合成技术、频闪图像匹配技术、频闪Mirau 显微干涉技术与显微激光多普勒测振技术有机结合,建立起了一套周期运动测量与瞬态运动测量相结合、单点运动测量与全视场运动测量相结合、满足不同MEMS 器件各种动态测试要求的集成的MEMS 三维六自由度微运动精密测量系统。

On the basis of all the experimental results and the molecular modelling study, it is considered that Jatrorrhizine and Berberine binds to the site I and site II mainly by hydrophobic interaction and there are hydrogen bond and electrostatic interactions.

荧光竞争实验以及分子对接研究表明药根碱和小檗碱的结合区域分别位于蛋白质的亚结构域ⅡA和亚结构域ⅢA中,主要通过疏水作用结合,但还包括静电作用力、氢键。

In light of the latest researches carried out by this research team,it discusses the status quo of the researches in oil charging and atomizing for electrostatic spraying with the emphasis on liquid atomizing in the electrical field of beam-plate electrode and key technologies for the development of electrostatic oiler.

对液体荷电雾化技术在试验和数值模拟两方面的研究现状进行回顾和综述,并结合课题组近年来的研究情况,论述液体荷电雾化技术在静电涂油领域的研究现状,重点探讨梁板电极电场下的油液雾化技术以及静电涂油机的开发研制过程的关键技术。

In aqueous solution no binding observed in crystal structure. In cyclohexane, one amylamine molecule is observed in the active site of trypsin and more sulfates are also found on enzyme surface, which are further proofs that electrostatic interaction are stronger in organic solvent.

在水溶液中,晶体结构难以观察到戊胺与牛胰酶的结合,在环己烷中,一个戊胺分子结合在胰酶的活性中心,同样酶表面观察到了更多的硫酸根,这些都进一步验证了有机溶剂中静电相互作用加强。

The electrochemical results indicated that the interaction between TH and CT-DNA is in the intercalative mode in the pH 7.2 phosphate buffer solution, but both intercalative and electrostatic modes exist in the pH 6.5 phosphate buffer solution. Fluorescence spectroscopic results showed that the fluorescence intensity of TH is efficiently quenched by CT-DNA bases.

电化学测量结果表明,在pH7.2的磷酸盐缓衝溶液中,TH与CT-DNA之间的作用方式以嵌入结合为主,在pH6.5的磷酸盐缓衝溶液中,TH与CT-DNA之间的作用方式既存在嵌入结合也存在静电作用。

The experiments confirm that Nuclear fast red bindto DNA to form a 1:1 association complex with the binding constant 7.29×10~5 L/mol,and the major binding mode of Nuclear fast red to DNA is electrostatic binding.However, at high iron strength, the major binding mode changes into intercalativebinding. Part four is about investigation on the interaction of purpurine with DNA.

结果显示,核固红与DNA主要以静电作用模式结合,结合位点为1,结合常数为7.29×10~5L/mol;而在高离子强度下,其主要作用模式改变为嵌插作用;第四部研究了红紫素与DNA的相互作用。

The results indicate that the 3D-QSAR model is significant and has good predictability, providing useful information for designing new good activity AHAS inhibitors prior to their synthesis.

根据CoMSIA模型的立体场、静电场、氢键给体场三维等值线图不仅直观地解释了结构与活性的关系,并且与用FlexX预测的结合模式相一致,证明了我们预测的结合模式是可靠的,为进一步设计高活性的标题化合物提供较好的理论指导。

The results show that methyl group strengthens the electrostatic attractions, but reduces the H-bonds effect, while benzyl group can make both electrostatic and H-bond effects strong. The theoretical results are identical with the results of the collectors flotation tests. Collecting ability of the quaternary amine salts is better than that of dodecylamine and dodecyl bimethyl amine. The quaternary amine salt containing benzyl group performs best, and it is little affected by pH value. Substitution of N-containing polar group in amine collectors can impact the aluminosulicate minerals flotation.

研究结果表明:甲基的取代可增强阳离子的静电作用能力,同时,削弱它与矿物表面之间的氢键作用;苄基的取代不仅增强药剂的静电效应,而且增加氢键的结合能力;理论分析结果与浮选试验结果一致,季铵盐的浮选能力较伯胺与叔胺的强,连有苄基的季铵盐对铝硅酸盐矿物的捕收能力最强,且受pH值影响小。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。