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Abstract] Objective For the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.Methods Aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with pH 4, human immunoglobulin and human hepatitis B immunoglobulin for intravenous injection with pH 4/pasteurization,treatment on human fibrinogen and human coagulation factor Ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.The mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.

目的 分析血液制品特定灭活因子的时效动力学曲线,科学性地评价与改进不合理的病毒灭活参方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒,人血白蛋白采用巴氏消毒法,狂犬病人免疫球蛋白采用低pH常温孵放法,注人免疫球蛋白、注人乙肝免疫球蛋白采用低pH/巴氏消毒法;人纤维蛋白原、人凝血因子Ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料,统计3批样品取样点的残余病毒滴度均值、标准差与变异系数,制作灭活病毒动力曲线图并进行分析。

Abstract] objective for the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.methods aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with ph 4, human immunoglobulin and human hepatitis b immunoglobulin for intravenous injection with ph 4/pasteurization,treatment on human fibrinogen and human coagulation factor ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.the mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.results human albumin pasteurization inactivated vsv and sindbis virus,hrig low ph inactivated vsv and sindbis virus,hrig low ph inactivated hiv virus,ivig low ph/pasteurization inactivated hiv virus,ivig low ph inactivated hiv virus,hbig low ph/pasteurization inactivated vsv,sindbis and polio virus.conclusion suggestion about improvement on unreasonable parameter and standard of virus inactivation is made,cultivate target virus directly from final product by appropriate cell or method to monitoring viral safety of blood plasma product is advanced.

目的 分析血液制品特定灭活因子的时效动力学曲线,科学性地评价与改进不合理的病毒灭活参数。方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒,人血白蛋白采用巴氏消毒法,狂犬病人免疫球蛋白采用低ph常温孵放法,注人免疫球蛋白、注人乙肝免疫球蛋白采用低ph/巴氏消毒法;人纤维蛋白原、人凝血因子ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料,统计3批样品多个取样点的残余病毒滴度均值、标准差与变异系数,制作灭活病毒动力曲线图并进行分析。结果人血白蛋白巴氏灭活vsv与sindbis病毒,hrig低ph灭活vsv和sindbis病毒,hrig低ph灭活hiv病毒,ivig低ph/巴氏灭活hiv病毒,ivig低ph灭活hiv病毒,hbig低ph/巴氏灭活vsv、sindbis与polio病毒。结论建议改进病毒灭活验证标准与不合理的灭活参数;采用终产品样品通过合适细胞或方法直接培养目标病毒来有效监测血液制品的病毒安全性。

Methods Aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with pH 4, human immunoglobulin and human hepatitis B immunoglobulin for intravenous injection with pH 4/pasteurization,treatment on human fibrinogen and human coagulation factor Ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.The mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.

系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒,人血白蛋白采用巴氏消毒法,狂犬病人免疫球蛋白采用低pH常温孵放法,注人免疫球蛋白、注人乙肝免疫球蛋白采用低pH/巴氏消毒法;人纤维蛋白原、人凝血因子Ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料,统计3批样品多个取样点的残余病毒滴度均值、标准差与变异系数,制作灭活病毒动力曲线图并进行分析。

The behaviors of SRC beam transferring structure, which is the major research of this dissertation, is studied from four aspects:(1)Pseudo-static test of transfer structure shaking table test of a whole frame model with transferring story and a field measurement;(2)Push-over analysis;(3)the test research and theoretical analysis of joints for SRC transferring frame;(4)the research on the creep and shrinkage of SRC transfer beams.

本文的主要工作是研究型钢混凝土梁式转换框架结构的受力性能问题,为此,从以下四个方面:①转换框架结构的拟力试验、整体结构的模拟地震振动台试验和施工现场实测;②力弹塑性分析;③型钢混凝土转换框架节点的试验研究与理论分析;④施工阶段转换大梁的徐变、收缩特性的研究,展开了对课题的研究。

From the wide verification and detailed analysis, such as a great amount of tests for single pile and two tests for composite pile foundation, a field measurement study lasted for more than 4 years for two same buildings designed by new design method presented in this paper, and a long term survey of settlement for 28 buildings found on composite pile foundation, it has been shown that this new design method is feasible and reasonable.

通过大量的单桩载试验、复合桩基载试验、对按提出的复合桩基方法设计的两幢体型、面积和层数相同的房屋的长期监测试验以及大量的建筑物的长期沉降观测,进行检验和深入而详细的分析。

Operators are very clear about the automatic shutdown does not work or defective and great taste with a ceiling of paper and paper inaccurate in place when the device cannot be automatically, delivery tooth row cannot be protected.

操息职员都格外澄辉自不泊车不起息用或失灵,不离感味着吸纸和输纸不不确到位时摆设不离不克不及当场自不泊车,收纸牙排不离不克不及获得爱护。

From the TV series since the shooting, high-Xin's "Wan Ku children modeling","Gao Xin Alyssa Chia wins sub-war","hand in hand Alyssa Chia begging on the streets" and others became the focus of major media coverage.

从电视剧开拍以来,高鑫的&纨绔子弟造型&、&高鑫贾雯夺子大战&、&携手贾雯街头行乞&等事件成为各大媒体争相报道的焦点。

Jingan Branch is not even though the defendant, but Oh is still trying to own the legal knowledge to analyze the elusive "shadow hospital": It is not an independent legal entity and should not bear civil liability independently, nor permit to practice medical institutions ; its origins surgeon, nursing staff from the Jing'an District Central Hospital; it does not have an independent operating theaters, medical record room, no drugs, did not check equipment, apart from a director of the department permit brand hang out, it is actually anything NOT.

尽管安分院已经不是被告,但吴胜则仍试图以自己的法律知识来分析这家难以琢磨的&影子医院&:它不是独立法人,不能独立承担民事责任,更没有医疗机构执业许可证;它的手术医生来路不明,护理人员来自于安区中心医院;它没有独立的手术室、病案室,没有药品、没有检查设备,除了一个主管部门允许挂出的牌子,它其实什么都没有。

Methods 41 patients with chronic cardiac failure treated with same concentration and dosage of sodium nitroprusside intraenous drip were studied.

方法选择应用同样浓度、剂量硝普钠滴治疗的慢性心衰患者 41例,在滴过程中,每 1 5min由专人为患者测血压 1次,据血压下降幅度和患者症状随时调整滴速,保持血压平均下降(1 。1 5±0 。0 2 )kPa。

Harness and sling like static rope, they did not scalable, the impulse coefficient of a fall, we can see the protection of static rope off arising from the impact can sling, seat belts, locks other equipment failures, even more dangerous is such a big impact those who can make off the waist fractures.

绳套和扁带就如同力绳,它们也没有延展性,在冲坠系数一节中我们可以看到用力绳保护脱落时所产生的冲击力可以使扁带、安全带、铁锁等装备失效,更危险的是这样大的冲击力可以直接使脱落者腰部骨折。

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Plunder melds and run with this jewel!

掠夺melds和运行与此宝石!

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻,也许正是在通往天国的路上,我体验着这白色的晕旋。

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