青霉

Skeleton and chain syntheses have become highlights of study and development of new carbapenems.

骨架和侧链的化学合成是碳青霉烯类药物研究和开发的重点和热点方向。

The side chain of thioacetic acid has been sythesized from the material of acetic acid via four steps, then synthesized the key intermediate of 2-hydroxypenem via displacement, P〓induced cyclization and hydrolyzed reaction from the material of azetidinone.

以羟乙酸为原料，经四步反应合成了侧链化合物硫基取代的羟乙酸，发生取代反应导入到经七步合成的单环氮杂环丁酮中，然后发生酰化，Wittig诱导环化，水解等五步反应合成关键中间体2-羟甲基青霉烯。

The results of bioassay indicated: 1 The new compound (compound 6) and other three compounds (compound 1, 2 and 5) showed strong anti-HIV activity (EC50.064μg/ml), compound 3 and 4 showed less activity (EC50=6.18μg/ml and 12.85μg/ml respectively); Compound 5 and 6 showed weak cytotoxicity, and compound 1-4 showed moderate cytotoxicity; 2 Compound 5 and 6 were activated to all the four tested microbial; Compound 1, 2 and 13 were activated to all the three tested bacterial, but were unactivated to the tested fungi, Penicillium avellaneumUC-4376; One of the test bacterial, Staphylococcus aurues, seemed to be sensitive to all the eleven triterpenoids.

新化合物（化合物6）和化合物1、2、5具有强烈的体外抗HIV活性，其EC50值均小于0.064μg/ml，化合物3和4也具有抗HIV活性，但活性相对较弱，EC50值分别为6.18μg/ml和12.85μg/ml；化合物1-6都具有一定的细胞毒性，且化合物5和6的细胞毒性明显弱于化合物1-4的。 2）新化合物（化合物6）和化合物5对所有四种试验菌都有一定的活性；化合物1 、2和13对三种细菌均有一定的活性，但对真菌橙色青霉UC-4367（Penicillium avellaneum UC-4376）无活性；金黄色葡萄球菌对所有11个三萜都较为敏感。

At present the main treatment is to increase endurance, and actively prevent and treat lung infection, and control fibrosis drug use, such as penicillamine, colchicine, azathioprine, and so on, can also be supplemented by anti-vascular inflammatory drugs, such as low-dose glucocorticoids , vasodilating agents, such as anticoagulants.

目前治疗主要是提高抵抗力，积极防治肺部感染，同时用控制纤维化的药物，如青霉胺、秋水仙碱、硫唑嘌呤等，也可辅以抗血管炎症药物，如小剂量糖皮质激素、扩血管剂、抗凝剂等。

Objective To modify the synthesis of Benzhydryl 2α- methyl - 2β- [ ( 1,2,3 -triazol - 1 - yl)- methyl ] penicillanate - 1,1 - dioxide, the key intermediate of β- lactamase in-hibitor tazobactam.

目的 改进β-内酰胺酶抑制剂泰唑巴坦关键中间体2α-甲基-2β[(1，2，3-三唑-1-基)-甲基]青霉烷酸砜二苯甲酯的合成。

Sometimes, medication that chelates copper, especially penicillamine, can worsen the person's neurologic function.

有时服药，螯合物铜，尤其青霉胺能恶化人的神经功能。

Various grains and inocula were investigated for carotenoid production by solid-state fermentation using Penicillium sp.

研究了 7种谷物培养基及相关因素对青霉 PT95菌株进行类胡萝卜素固态发酵的影响作用。

Hybridoma cell strains were selected after fusion of mouse SP2/0 myeloma cells with spleen cells isolated from BALB/c mice that had been immunized with Penicillic Acid conjugated to bovine serum albumin by ELISA.

以合成的完全抗原PA-BSA免疫小鼠，采用杂交瘤技术，经细胞融合、克隆筛选、扩大培养获得一株针对青霉酸的杂交瘤细胞4C2-F8-D2。

Methods Mouse peritoneal macrophages were cultured in the presence of heat-killed yeast-phase PM for 24 h,and the average fluorescence intensity of TLR-2,TLR-4,and Dectin-1 in the macrop...

结论马尔尼菲青霉上调了巨噬细胞模式识别受体TLR-2、TLR-4及Dectin-1的表达，巨噬细胞的激活与TLR-2、TLR-4及Dectin-1的表达上调相关。

Objective To study the effects of heat-killed Penicillium marneffei on the expressions of toll-like receptor-4 (TLR-4),toll-like receptor-2 (TLR-2) and dendritic cell associated C-type lectin-1 (Dectin-1)and the production of the proinflammatory cytokine tumor necrosis factor-α.

目的 研究马尔尼菲青霉对巨噬细胞模式识别受体TLR-2、TLR-4、Dectin-1的表达及促炎因子TNF-α分泌的影响。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。