青藤碱

Objective: Study the analgesic and anti-inflammatory QSAR of sinomenine's derivatives.

目的：研究青藤碱衍生物镇痛抗炎作用的定量构效关系。

OBJECTIVE To prepare the sinomenine hydrochloride sustained-release pellets and study its in vitro drug release.

目的：制备盐酸青藤碱缓释微丸，并对其体外释药行为进行研究。

The present method is simple, fast, and accurate; it is suitable for determination of sinomenine content in Sinomenium acutum.

该方法简单快捷，结果准确，适用于测定青风藤中青藤碱的含量。

Objective: To study bioequivalence of Sinomenine patch made by different preparation process, and to testify feasibility and superiority of microdialysis as a new method in topical bioequivalence study.

目的：研究不同制剂工艺的青藤碱凝胶贴剂的生物等效性，探讨微透析技术在生物等效性研究中的可行性和优越性。

Results The rate of FLS proliferation was significantly reduced in groups treated by sinomenine.

结果 经青藤碱干预后的人成纤维样滑膜细胞的增殖率受到显著抑制(P.05)，其中高剂量组的改变差异尤为显著(P.01)。

Objective: To study bioequivalence of Sinomenine patch made by different preparation process, and to testify feasibility and superiority of microdialysis as a new method in topical bioequivalence study.

中文摘要：目的：研究不同制剂工艺的青藤碱凝胶贴剂的生物等效性，探讨微透析技术在生物等效性研究中的可行性和优越性。

Objective: To prepare sinomenine gel and study its skin penetration in vitro .

结果：实验结果表明，青藤碱凝胶剂体外透皮释药方程为Q=65.852t-55.677(r=0.991 9)，10 h累积渗透量为638μg/cm2。

The permeation process of sinomenine gel in vitro coul...

选择2％azone作为青藤碱凝胶剂的促透剂。

Whole cell patch clamp technique was used to investigate the effect of sinomenine on sodium current and L-type callium in isolated guinea pig ventricular myocytes.

应用膜片钳全细胞记录技术研究青藤碱对酶解分离的豚鼠单个心室肌细胞膜钠离子电流、L型钙电流的影响。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。