青藤碱

Renal interstitial fibrosis ; LN ; FN ; Metaplasia factor ; Hdrochloric acid kukoline

肾间质性纤维化；层粘连蛋白；纤维连接蛋白；组织转化因子；盐酸青藤碱

The mouse was carried out half nephric duct ligation to induce the renal interstitial fibrosis animal model,afterwards,to set up three groups,control group,sham operation group(intragastric administration with normal sodium according to 10ml/kg weight),treatment group...

采用小鼠单侧输尿管结扎法诱导肾间质纤维化的动物模型，用盐酸青藤碱治疗，并设对照组、假手术组(小鼠每日按10m l/kg体重用生理盐水灌胃，直至治疗结束)、治疗组(选用正清风痛宁缓释片按每日30mg/kg体重给小鼠灌胃，连续3周，)，检测血尿素氮、血肌酐、血清层粘连蛋白、纤维连接蛋白的含量，免疫组化法测肾脏组织转化因子β1(TNF-β1)的表达并进行肾脏病理学的观察。

Objective To compare the relative bioavailabilities of different sinomenine hydrochloride crystal in healthy volunteers.

目的比较盐酸青藤碱不同晶形在人体的相对生物利用度。

This method is simple, rapid and accurate, which is suitable for the quality control of sinomenine hydrochloride sustained-release pellets.

该方法简便、准确、快速，可用于盐酸青藤碱缓释微丸的含量测定及质量控制。

Objective: To optimize the formulation and preparation process of sinomenine liposomes.

中文摘要：目的：优化青藤碱脂质体的膜材处方，并进行制备工艺研究。

Objective To establish an HPLC method for determining the content of sinomenine hydrochloride in sustained-release pellets.

目的 建立盐酸青藤碱缓释微丸的含量测定方法。

Effects of sinomenine on IL1β, IL8 gene expression of human peripheral blood.

青藤碱对人外周血单个核细胞IL1β和IL8细胞因子基因表达的影响。

Objective:To study the effects of sinomenine on apoptosis in cutured neonatal rat cardiomyocytes induced by H2O2 and its possible mechanism.

中文摘要：目的：探讨青藤碱对H2O2诱导乳鼠心肌细胞凋亡的影响及其可能的作用机制。

Objective: To prepare sinomenine gel and study its skin penetration in vitro.

目的：制备青藤碱凝胶剂，研究其透皮渗透性能。

The anxiolytic-like effects of sinomenine were investigated by means of behavioral pharmacology for the first time.

本课题主要运用行为药理学手段研究了青藤碱(sinomenine，SN)的抗焦虑作用及其对中枢神经系统的影响。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。