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Gestational and lactational exposure to endosulfan did not show any demasculinizing or feminizing effect in rats, and sperm production and fertility of the male offspring were not affected.

大鼠孕期和哺乳期经口接触硫丹,没有引起雄性子代的雌性化,也不影响雄性子鼠的生精功能和生育力。

Whereas, in the present results, none of these demasculinizing or feminizing effects was observed in male offspring of rat after gestational and lactational exposure to endosulfan.

说明大鼠孕期和哺乳期接触硫丹,对雄性子鼠没有明显的去雄性化或雌性化作用。

The result showed that all the males copulated successfully with the females within one week, indicating the male fertility was not affected after gestational and lactational exposure to endosulfan.

出生后90-95天,将每组10只成年雄性仔鼠与另外健康成年雌鼠按1∶1同笼交配,每天查阴栓以判断雄性生育力,结果各组动物都在1周内成功交配。

Considering the merits of in vivo studies in biotransformation i. e. activation or inactivation, protein-binding such as sex hormone binding protein , toxicokinetics, and more evaluative in hazard identification and risk assessment, we selected a battery of short-term and long-term in vivo studies, including uterotrophic assay in weaning mice and ovariectomized adult mice, an in vivo multiple endpoints assay, and a gestational and lactational exposure assay to identify the estrogenic effects of endosulfan on the offspring.

考虑到体内试验在代谢转化、血浆蛋白如性激素结合蛋白的结合、代谢动力学等方面比体外试验优越,在危害鉴定和危险度评定中更有价值,我们选择了多项体内试验,包括对幼年小鼠和卵巢切除成年小鼠的子宫增殖作用、对成年去势小鼠的体内多终点观察以及大鼠孕期和哺乳期接触对雄性子代生殖系统结构和功能的改变,即去雄性化或雌性化作用等,来验证硫丹的体内雌激素样作用。

Androgen receptors are not the master regulators for male behaviours, but rather, the researchers say, a "gain control mechanism" which amplifies such behaviours—or, when the receptors are absent, dials laddish behaviour down.

雄性激素受体不是雄性行为的主要控制因素,相反,这一行为是由&增益控制机制&加强的,换句话说,当受体减少时,好斗的欲望也会减弱。

The mammiferous testis perform important functions of producing sperm and secreting male hormone.

雄性哺乳动物的睾丸具有生精和分泌雄性激素等重要的功能。

Results: 1 Intense ERα immunoreactivity localized in the hypertrophic and maturative layer, and some immunoreactivity was found in osteoblasts of mandible and temporal bone, while no immunoreactivity was found in the disc and synovium. 2 The expression of ERα in male rats TMJ cartilage was higher than that in female ones. 3 In the condyle cartilage of male rats, the density of ERα positive cells decreased with age, which kept stable after 16 weeks of age. 4 In the condyle cartilage of male rats, the density of ERα positive cells was stable from birth to 8 weeks, but decreased from 16 weeks to 12 months, while the density in 18-month group recovered to the level of 8 weeks. Conclusion: TMJ is one of target organs of estrogen, and ERα plays an important role in the effect of estrogen on TMJ.

结果:1TMJ中ERα主要在髁突软骨的肥大层和过渡层表达,下颌骨和颞骨的骨细胞也有少量表达,而关节盘、滑膜中几乎无表达;2雄性SD大鼠髁突软骨中ERα的表达明显强于同龄的雌性大鼠;3在雄性大鼠TMJ髁突软骨中阳性细胞密度随年龄增长逐渐降低,16周以后逐渐维持在相对稳定的水平;4雌性大鼠从出生后到8周龄阳性细胞密度基本稳定,在16周龄至12月龄年龄组阳性细胞密度显著降低,而在18月龄后又恢复到8周龄以前的水平。

The isonucleus-allocytoplasmic materials ms-Xinong 1376,-Xinong 1376, and ms-Xinong 1376 were used to investigate the protein expression profile in mononucleated anaphase anthers of wheat (Triticum aestivum L.) after silver staining and analysis by PDQuest software. About 320 to 350 distinct protein spots were detected reproducibly.

为了研究小麦雄性不育蛋白表达机制,以具有异质同核的3个亲本:即遗传型不育系ms-西农1376、对应的保持系-西农1376和生理型(化学杀雄剂SQ-1诱导)雄性不育系ms-西农1376为材料,利用IEF/SDS-PAGE凝胶电泳技术,对发育到单核后期的花药全蛋白特异性进行了比较分析,得到320~350个清晰的蛋白点。

Height of Bitches --From28 inches upwards. There is no objection to a bitch being large, unlesstoo coarse, as even at her greatest height she does not approach thatof the dog, and therefore could not be too big for work as overbig dogsare.

雌性的高度:28英寸以上,只要不显得粗糙,不拒绝更大的雌性,她适合的最大高度不应该接近雄性的高度,就象不可能有太大的雄性一样。

Methods Six weeks old male Fischer 344 rats (F344) were used as donors, and six weeks old male F344alb as recipients. All F344alb were divided into 4 groups: group Ⅰ(n=10) was untreated; group Ⅱ(n=10) was treated with CCl4 but no γ-irradiation and transplantation; group Ⅲ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, but without CCl4 treatment; group Ⅳ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, with CCl4 treatment. The BMCs prepared from the donors were infused via the penial veins of recipients immediately after whole body γ-irradiation (7.5Gy) and CCl4 treatment: 4 weeks after BMCs transplantation, CCl4 were injected into peritoneal cavity twice a week for 4 weeks.

雄性F344大鼠为供体,而雄性F344alb为受体,分为4组:组Ⅰ(n=10)为正常对照组,不接受肝损处理,无全身射线照射和阴茎静脉骨髓细胞移植;组Ⅱ(n=10)为肝损无移植组,只接受肝损处理,无全身射线照射和阴茎静脉骨髓细胞移植;组Ⅲ(n=10)为正常移植组,全身射线照射后阴茎静脉移植骨髓细胞1×10^7;组Ⅳ(n=10)为肝损移植组,接受CCl4注射肝损,全身射线照射后阴茎静脉骨髓细胞移植1×10^7BMCs,其中,γ-照射剂量为7.5Gy,F344大鼠的BMCs经受体的阴茎静脉注入。

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